Details of the Target

General Information of Target

Target ID LDTP03903
Target Name Signal transducer and activator of transcription 3 (STAT3)
Gene Name STAT3
Gene ID 6774
Synonyms
APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Target Type
Successful
Target Bioclass
Transcription factor
Family
Transcription factor STAT family
Subcellular location
Cytoplasm
Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes.
TTD ID
T29130
Uniprot ID
P40763
DrugMap ID
TTH8FZW
Ensemble ID
ENST00000264657.10
HGNC ID
HGNC:11364
ChEMBL ID
CHEMBL4026

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R688W DBIA    Probe Info 
CCK81 Insertion: p.T494YfsTer55 DBIA    Probe Info 
CHL1 SNV: p.R688W DBIA    Probe Info 
ECC2 SNV: p.Q202K DBIA    Probe Info 
EFO27 SNV: p.V310M DBIA    Probe Info 
JURKAT Deletion: p.R729AfsTer3
SNV: p.L78F		 Compound 10    Probe Info 
MOLT4 SNV: p.A406V; p.R729H IA-alkyne    Probe Info 
OVISE SNV: p.V375I DBIA    Probe Info 
RKO Deletion: p.E616del DBIA    Probe Info 
SNU1 SNV: p.A46T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.45  LDD0214  [1]
m-APA
 Probe Info  		15.00  LDD0402  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y686(20.00); Y640(8.79)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K140(5.33); K199(5.00); K383(10.00); K601(10.00)  LDD0277  [6]
Probe 1
 Probe Info  		Y176(19.21); Y640(3.14)  LDD3495  [7]
SAHA-CA-4PAP
 Probe Info  		4.50  LDD0269  [8]
THZ1-DTB
 Probe Info  		C259(1.09)  LDD0460  [9]
BTD
 Probe Info  		C687(0.65)  LDD2091  [10]
Sulforaphane-probe2
 Probe Info  		3.08  LDD0042  [11]
DA-P3
 Probe Info  		4.97  LDD0179  [12]
AHL-Pu-1
 Probe Info  		C712(2.16); C259(7.51)  LDD0168  [13]
HHS-482
 Probe Info  		Y176(5.48)  LDD0285  [14]
HHS-475
 Probe Info  		Y68(0.35); Y79(0.41); Y45(0.77); Y176(0.87)  LDD0264  [15]
DBIA
 Probe Info  		C259(0.96); C542(0.91)  LDD0078  [16]
5E-2FA
 Probe Info  		H81(0.00); H131(0.00); H147(0.00); H19(0.00)  LDD2235  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C426(0.00); C108(0.00); C542(0.00); C367(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C426(0.00); C108(0.00); C468(0.00); C367(0.00)  LDD0036  [18]
Lodoacetamide azide
 Probe Info  		C108(0.00); C468(0.00); C367(0.00); C542(0.00)  LDD0037  [18]
NAIA_4
 Probe Info  		C687(0.00); C259(0.00); C367(0.00); C426(0.00)  LDD2226  [19]
WYneN
 Probe Info  		C687(0.00); C418(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
ENE
 Probe Info  		N.A.  LDD0006  [20]
IPM
 Probe Info  		N.A.  LDD0005  [20]
VSF
 Probe Info  		C718(0.00); C259(0.00); C712(0.00)  LDD0007  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		H131(0.00); C542(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		C542(0.00); C712(0.00); C718(0.00)  LDD0236  [24]
AOyne
 Probe Info  		14.60  LDD0443  [25]
NAIA_5
 Probe Info  		C426(0.00); C367(0.00); C687(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		Y705(0.00); K707(0.00); Y45(0.00); K49(0.00)  LDD2240  [26]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		51.63  LDD1948  [27]
FFF probe11
 Probe Info  		6.00  LDD0472  [28]
FFF probe13
 Probe Info  		5.16  LDD0476  [28]
FFF probe2
 Probe Info  		5.08  LDD0463  [28]
FFF probe3
 Probe Info  		10.26  LDD0465  [28]
STS-1
 Probe Info  		N.A.  LDD0136  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]
Alk-rapa
 Probe Info  		9.38  LDD0213  [31]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [32]
DA-2
 Probe Info  		N.A.  LDD0070  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C687(0.69)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C687(1.03)  LDD2112  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C687(0.67)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C687(3.18)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C687(1.45)  LDD2152  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C687(0.52)  LDD2131  [10]
 LDCM0025  4SU-RNA HEK-293T C712(2.16); C259(7.51)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C712(3.96); C259(2.08); C542(4.99); C426(2.00)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C251(0.83); C108(0.87); C259(0.77); C328(0.86)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C251(0.82); C108(0.88); C259(0.82); C328(0.90)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C251(0.88); C108(0.69); C259(0.96); C542(1.18)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C251(0.72); C108(0.83); C259(0.84); C542(1.03)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C251(0.83); C108(0.84); C259(0.85); C542(1.05)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C251(0.72); C108(0.82); C259(0.85); C542(1.10)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C251(0.72); C108(0.77); C259(0.74); C542(1.03)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C251(0.76); C108(0.73); C259(0.83); C542(1.14)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C251(0.87); C108(0.75); C259(0.95); C542(1.12)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C251(0.79); C108(0.75); C259(0.81); C542(1.05)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C251(1.00); C108(0.60); C259(0.99); C542(1.24)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C251(0.86); C108(0.76); C259(0.84); C542(1.11)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C251(0.81); C108(0.75); C259(0.89); C328(0.93)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C251(0.85); C108(0.85); C259(0.89); C542(1.15)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C251(0.83); C108(0.88); C259(0.87); C542(1.07)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C251(0.79); C108(0.72); C259(0.83); C542(1.04)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C251(0.95); C108(1.29); C259(1.01); C328(1.01)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C251(0.96); C108(0.66); C259(0.97); C328(0.98)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C251(0.87); C108(0.57); C259(0.87); C328(0.99)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C251(0.90); C108(0.83); C259(0.89); C328(0.97)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C251(0.97); C108(0.95); C259(0.97); C328(0.87)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C251(0.96); C108(0.75); C259(0.91); C328(1.02)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C251(0.91); C108(0.72); C259(0.88); C328(0.89)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C251(0.98); C108(0.87); C259(0.97); C328(0.95)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C251(0.94); C108(0.74); C259(0.99); C328(0.98)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C251(1.10); C108(0.93); C259(1.07); C328(0.92)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C251(0.92); C108(0.87); C259(0.88); C328(0.93)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C251(0.90); C108(0.60); C259(0.88); C328(0.78)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C251(0.98); C108(0.94); C259(0.93); C328(0.86)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C251(0.88); C108(0.75); C259(0.88); C328(0.95)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C251(0.89); C108(0.67); C259(0.83); C328(0.93)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C251(0.99); C108(0.70); C259(0.95); C328(0.83)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C251(1.33); C108(1.15); C259(1.22); C328(1.03)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C251(1.97); C108(1.30); C259(1.84); C328(0.95)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C251(1.24); C108(1.11); C259(1.18); C328(0.92)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C251(1.34); C108(1.05); C259(1.28); C328(0.92)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C251(1.37); C108(1.16); C259(1.32); C328(1.03)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C251(1.31); C108(1.06); C259(1.26); C328(0.90)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C251(1.31); C108(1.24); C259(1.38); C328(0.94)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C251(1.40); C108(0.95); C259(1.37); C328(0.99)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C251(1.63); C108(1.45); C259(1.65); C328(1.04)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C251(1.24); C108(1.19); C259(1.18); C328(1.11)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C251(1.42); C108(1.20); C259(1.43); C328(0.96)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C251(1.60); C108(1.18); C259(1.57); C328(0.98)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C251(0.71); C108(0.83); C259(0.80); C328(0.76)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C251(1.43); C108(1.13); C259(1.46); C328(1.05)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C251(1.41); C108(1.10); C259(1.46); C328(0.96)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C251(1.99); C108(1.19); C259(1.99); C328(0.92)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C251(0.91); C108(0.82); C542(0.84); C259(0.91)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C108(0.64); C542(0.82); C328(0.89); C251(1.08)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C108(0.70); C542(0.92); C328(0.96); C712(1.08)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C108(0.61); C251(0.79); C542(0.94); C259(0.97)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C108(0.62); C542(0.92); C251(0.97); C328(0.99)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C108(0.72); C251(0.83); C328(1.08); C259(1.14)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C108(0.59); C251(0.79); C328(0.90); C542(0.97)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C108(0.79); C251(0.79); C259(0.79); C328(0.99)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C108(0.62); C328(0.92); C542(0.94); C251(0.95)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C108(0.66); C542(0.88); C328(0.98); C712(1.29)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C108(0.59); C251(0.85); C328(0.89); C259(0.96)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C108(0.74); C251(0.84); C259(1.07); C328(1.07)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C251(1.06); C108(0.67); C259(1.17); C328(0.98)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C251(1.43); C108(0.59); C259(1.65); C328(0.97)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C251(0.74); C108(0.77); C259(0.93); C328(0.99)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C251(0.89); C108(0.67); C259(1.01); C328(1.00)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C718(0.97); C328(1.02); C712(1.04); C542(1.13)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C328(0.84); C542(1.13); C259(1.14); C718(1.16)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C328(0.92); C718(0.95); C712(0.97); C542(1.01)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C542(0.88); C259(0.95); C712(0.97); C718(0.97)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C328(0.92); C718(0.98); C542(1.03); C712(1.04)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C328(0.91); C259(0.92); C251(0.96); C542(1.14)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C328(0.88); C259(1.00); C251(1.00); C542(1.16)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C328(0.92); C542(1.12); C259(1.13); C251(1.17)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C718(0.97); C712(1.02); C328(1.08); C259(1.10)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C259(0.70); C328(0.81); C251(0.90); C712(1.02)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C259(0.70); C328(0.79); C251(0.95); C542(0.99)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C259(0.70); C251(0.83); C328(0.84); C542(0.92)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C328(0.76); C259(0.86); C542(1.03); C712(1.17)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C328(0.71); C259(0.74); C251(0.79); C542(0.92)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C542(0.91); C259(0.94); C251(0.98); C712(1.02)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C259(0.70); C328(0.71); C251(0.76); C542(1.03)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C259(0.61); C251(0.71); C328(0.73); C542(0.94)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C328(0.68); C259(0.78); C251(0.88); C542(1.03)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C328(0.70); C259(0.74); C251(0.76); C542(0.97)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C328(0.71); C259(0.73); C251(0.79); C542(1.08)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C542(1.05); C328(1.15); C712(1.18); C718(1.18)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C542(0.93); C328(0.99); C251(1.07); C259(1.08)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C542(0.85); C328(0.95); C251(0.98); C259(0.99)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C251(1.00); C259(1.01); C542(1.03); C328(1.13)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C542(1.00); C328(1.06); C251(1.08); C259(1.10)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C259(0.88); C108(0.89); C251(0.91); C542(0.93)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C542(1.04); C328(1.04); C251(1.09); C259(1.10)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C542(0.83); C251(0.92); C259(0.92); C328(0.95)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C328(0.98); C542(1.05); C259(1.08); C251(1.08)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C542(0.90); C328(0.93); C259(0.97); C251(0.98)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C259(0.97); C542(0.98); C251(0.98); C328(1.01)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C328(0.89); C542(0.99); C259(1.08); C251(1.09)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C108(0.91); C542(0.93); C251(0.93); C328(0.94)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C542(0.84); C108(0.88); C712(0.97); C718(0.97)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C712(0.77); C718(0.77); C108(0.82); C542(0.88)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C251(0.83); C108(0.93); C712(0.93); C718(0.93)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C712(0.86); C718(0.86); C542(0.90); C259(0.90)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C108(0.70); C328(0.91); C712(0.95); C718(0.95)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C251(0.92); C259(0.92); C328(0.96); C712(1.00)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C108(0.70); C251(0.87); C542(0.91); C328(0.92)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C108(0.92); C328(0.97); C542(1.00); C259(1.11)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C108(0.83); C542(0.86); C328(0.98); C251(1.02)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C108(0.76); C328(0.91); C542(0.94); C251(1.03)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C328(0.85); C251(0.93); C108(1.07); C542(1.10)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C251(0.79); C259(0.80); C712(0.93); C718(0.93)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C251(0.73); C259(0.74); C542(1.06); C712(1.13)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C251(0.77); C259(0.84); C328(0.94); C712(0.95)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C108(0.68); C251(0.82); C259(0.84); C542(0.96)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C251(0.54); C259(0.61); C712(0.90); C718(0.90)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C259(0.67); C251(0.67); C712(0.71); C718(0.71)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C251(0.90); C712(0.94); C718(0.94); C259(0.97)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C251(0.70); C259(0.79); C712(0.82); C718(0.82)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C251(0.70); C259(0.74); C712(0.89); C718(0.89)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C712(0.75); C718(0.75); C251(0.77); C259(0.81)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C712(0.77); C718(0.77); C251(0.81); C259(0.84)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C251(0.77); C259(0.81); C328(0.85); C712(0.87)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C251(0.69); C259(0.69); C328(0.85); C108(0.90)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C108(0.83); C328(0.87); C542(1.01); C712(1.04)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C542(0.94); C251(0.95); C712(0.95); C718(0.95)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C108(0.71); C328(0.83); C251(0.85); C259(0.85)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C108(0.85); C712(0.94); C718(0.94); C328(0.99)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C108(0.83); C328(0.96); C542(1.05); C712(1.05)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C251(1.18); C108(0.78); C328(0.99); C259(1.18)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C251(0.92); C259(0.92); C328(0.93); C108(0.98)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C108(0.92); C328(1.05); C251(1.20); C259(1.20)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C108(0.88); C328(0.93); C251(1.00); C259(1.00)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C108(0.88); C251(0.93); C259(0.93); C328(0.95)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C108(0.70); C251(0.83); C259(0.83); C328(0.86)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C108(0.82); C542(1.04); C328(1.07); C251(1.08)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C108(0.82); C251(0.86); C259(0.91); C328(0.95)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C108(0.79); C251(0.81); C259(0.81); C328(0.90)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C108(0.78); C251(0.84); C259(0.84); C328(0.87)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C108(0.94); C328(1.06); C542(1.35); C251(1.35)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C108(0.94); C251(0.97); C259(0.97); C328(1.05)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C251(0.86); C259(0.86); C328(0.95); C108(1.08)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C542(0.95); C712(0.99); C718(0.99); C328(1.01)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C251(0.90); C259(0.90); C542(1.00); C328(1.06)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C542(0.98); C712(1.05); C718(1.05); C328(1.10)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C542(1.06); C328(1.15); C108(1.29); C712(1.38)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C251(0.89); C259(0.89); C328(0.94); C542(1.01)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C712(1.20); C718(1.20); C542(1.23); C328(1.30)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C251(1.00); C259(1.00); C328(1.04); C108(1.12)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C328(0.98); C108(1.08); C251(1.11); C259(1.11)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C251(0.93); C259(0.93); C328(0.97); C542(1.04)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C542(1.05); C328(1.05); C712(1.05); C718(1.05)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C251(0.80); C259(0.80); C542(0.87); C328(0.99)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C542(0.97); C328(0.99); C251(1.06); C259(1.06)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C328(0.92); C542(1.06); C251(1.08); C259(1.08)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C108(0.64); C251(0.72); C259(0.90); C542(1.09)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C108(0.71); C712(0.93); C718(0.93); C251(0.95)  LDD0683  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C687(1.07)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C251(0.90); C108(0.90); C259(0.91); C328(1.06)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C108(0.78); C251(0.83); C542(0.85); C259(0.87)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C251(0.78); C108(0.78); C259(0.80); C328(0.94)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C259(0.96); C542(0.91)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C687(0.65)  LDD2091  [10]
 LDCM0087  Capsaicin HEK-293T 21.26  LDD0185  [12]
 LDCM0630  CCW28-3 231MFP C718(1.74); C259(1.55)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C542(0.00); C251(0.00); H131(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C687(1.00); C367(0.86)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C542(0.98); C712(1.37); C718(1.37); C259(1.89)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C542(1.03); C251(1.70); C259(1.71); C712(1.96)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C108(0.79); C542(0.86); C259(0.92); C328(0.95)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C328(0.79); C251(0.81); C108(0.82); C259(0.87)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C542(0.87); C328(0.94); C108(0.94); C251(1.03)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C108(0.80); C328(0.88); C542(0.91); C251(1.09)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C108(0.84); C542(0.91); C328(0.94); C251(0.94)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C259(0.87); C328(0.90); C251(0.93); C712(1.05)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C259(0.80); C251(0.88); C328(0.95); C718(1.12)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C328(0.88); C259(0.92); C251(0.96); C718(0.98)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C328(0.99); C259(1.00); C718(1.00); C251(1.06)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C328(0.86); C542(1.13); C259(1.16); C251(1.20)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C542(0.94); C251(1.39); C259(1.40); C712(1.54)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C328(0.88); C542(1.04); C259(1.29); C251(1.38)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C328(0.87); C542(1.15); C259(1.16); C251(1.22)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C328(0.99); C542(1.04); C259(1.22); C712(1.33)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C328(0.69); C259(0.81); C251(0.83); C542(1.08)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C328(0.76); C542(1.03); C259(1.04); C251(1.13)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C328(0.75); C542(0.95); C259(0.96); C251(1.02)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C259(0.77); C251(0.84); C328(0.85); C542(0.98)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C328(1.04); C542(1.28); C259(1.50); C251(1.50)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C542(0.99); C251(1.01); C259(1.02); C328(1.06)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C542(0.95); C328(0.96); C259(0.97); C251(0.99)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C251(0.99); C259(1.00); C542(1.05); C712(1.29)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C542(0.90); C251(1.00); C259(1.01); C328(1.03)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C328(0.80); C108(0.86); C542(0.87); C259(0.91)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C328(0.84); C108(0.86); C251(0.96); C542(1.00)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C542(0.87); C328(0.87); C108(0.91); C259(1.26)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C108(0.74); C328(0.84); C542(0.97); C251(1.07)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C251(0.92); C712(0.94); C718(0.94); C259(0.94)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C712(0.94); C718(0.94); C251(0.94); C328(0.98)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C712(0.91); C718(0.91); C328(0.91); C542(0.95)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C251(0.67); C259(0.70); C712(1.01); C718(1.01)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C251(0.81); C259(0.83); C542(0.97); C712(1.02)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C542(1.08); C251(1.29); C259(1.29); C712(1.48)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C542(1.02); C259(1.23); C251(1.29); C712(1.41)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C251(0.82); C328(0.84); C259(0.90); C542(0.92)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C328(0.82); C542(0.91); C108(0.97); C712(1.35)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C328(0.71); C108(0.81); C542(0.83); C712(0.92)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C328(0.82); C108(0.86); C542(0.90); C712(1.03)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C542(0.93); C712(1.09); C718(1.09); C251(1.22)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C328(0.78); C251(0.92); C542(0.93); C259(0.94)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C328(0.78); C108(0.84); C542(0.97); C259(1.28)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C328(0.89); C259(1.02); C251(1.02); C542(1.10)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C328(0.81); C251(0.88); C108(0.90); C259(0.98)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C251(0.96); C108(1.12); C259(1.01); C328(0.88)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C251(1.22); C108(1.09); C259(1.30); C328(0.88)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C251(1.00); C108(0.94); C259(1.09); C328(0.84)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C251(1.03); C108(0.99); C259(1.07); C328(0.91)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C251(1.14); C108(0.90); C259(1.22); C328(0.81)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C251(0.87); C108(1.14); C259(0.90); C328(0.82)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C251(1.06); C259(1.03); C542(0.96); C712(1.23)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C251(1.23); C108(1.12); C259(1.33); C328(0.89)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C251(0.87); C259(0.83); C328(0.95); C542(1.02)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C251(0.63); C259(0.60); C328(0.80); C542(0.86)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C251(2.70); C259(2.69); C328(0.82); C542(0.91)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C251(0.76); C259(0.76); C328(1.01); C542(1.03)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C251(0.75); C259(0.77); C328(0.92); C542(1.08)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C251(0.79); C259(0.79); C328(0.86); C542(1.04)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C251(0.68); C259(0.72); C328(0.93); C542(1.03)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C251(1.13); C259(1.11); C328(0.96); C542(1.09)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C251(2.03); C259(1.72); C542(0.96); C712(1.24)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C251(1.22); C259(1.17); C328(0.95); C542(1.05)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C251(0.70); C259(0.72); C328(0.89); C542(1.04)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C251(0.85); C259(0.86); C328(0.97); C542(1.26)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C251(0.74); C259(0.71); C328(0.90); C542(1.09)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C251(0.88); C259(0.82); C328(0.85); C542(1.00)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C251(0.82); C259(0.78); C328(0.94); C542(1.03)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C251(1.67); C108(1.32); C259(1.64); C328(1.00)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C251(1.55); C108(1.65); C259(1.55); C328(1.15)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C251(1.41); C108(1.84); C259(1.42); C328(1.06)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C251(1.39); C108(1.08); C259(1.35); C328(1.09)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C251(0.89); C259(0.87); C542(1.07); C712(1.04)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C251(1.43); C108(1.48); C259(1.43); C328(1.11)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C251(1.32); C108(1.65); C259(1.30); C328(1.06)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C251(1.26); C108(1.44); C259(1.28); C328(1.02)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C251(1.38); C108(1.18); C259(1.43); C328(0.93)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C251(1.56); C108(1.01); C259(1.56); C328(1.02)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C251(1.38); C108(1.32); C259(1.35); C328(0.92)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C251(1.31); C108(1.12); C259(1.33); C328(0.86)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C251(1.35); C108(1.21); C259(1.37); C328(0.88)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C251(1.21); C108(1.27); C259(1.22); C328(1.03)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C251(1.25); C108(1.15); C259(1.24); C328(1.09)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C251(0.82); C259(0.79); C542(0.90); C712(1.48)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C251(1.35); C108(1.09); C259(1.36); C328(1.02)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C251(0.94); C259(0.99); C328(0.97); C542(0.93)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C251(1.10); C259(1.15); C328(0.93); C542(1.05)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C251(0.79); C259(0.91); C328(0.94); C542(0.96)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C251(0.97); C259(1.01); C328(0.91); C542(0.94)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C251(0.98); C259(0.98); C328(0.98); C542(1.00)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C251(0.98); C259(0.97); C328(0.96); C542(1.04)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C251(0.80); C259(0.90); C328(0.91); C542(1.06)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C251(0.80); C259(0.97); C328(0.76); C542(0.89)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C251(0.70); C259(0.78); C328(0.65); C542(0.79)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C251(0.89); C259(0.86); C542(0.99); C712(1.05)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C251(0.69); C259(0.81); C328(0.74); C542(0.93)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C251(0.88); C259(0.91); C328(0.94); C542(1.00)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C251(0.93); C259(1.06); C328(1.03); C542(1.00)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C251(0.87); C259(0.92); C328(1.01); C542(1.10)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C251(0.88); C259(0.96); C328(0.88); C542(1.00)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C251(1.17); C259(1.09); C542(0.87); C712(1.12)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C251(1.31); C259(1.22); C542(1.15); C712(1.06)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C251(1.26); C259(1.14); C542(1.01); C712(1.09)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C251(1.01); C259(1.02); C542(0.98); C712(1.21)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C251(1.64); C259(1.65); C542(1.19); C712(2.59)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C251(1.31); C259(1.12); C542(0.83); C712(1.02)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C251(1.37); C259(1.15); C542(1.01); C712(1.08)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C251(1.60); C259(1.25); C542(1.14); C712(1.18)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C251(1.55); C259(1.21); C542(1.03); C712(1.26)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C251(1.38); C259(1.13); C542(1.19); C712(1.56)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C251(1.21); C259(1.08); C542(1.11); C712(1.08)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C251(1.11); C259(0.96); C542(1.10); C712(1.02)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C251(1.63); C259(1.30); C542(0.94); C712(1.06)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C251(1.40); C259(1.15); C542(1.05); C712(1.26)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C251(1.34); C259(1.15); C542(1.28); C712(1.35)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C251(1.03); C259(1.03); C542(1.00); C712(1.17)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C251(5.34); C259(3.52); C542(1.06); C712(1.33)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C251(1.04); C108(0.99); C259(1.05); C328(0.95)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C251(1.22); C108(0.83); C259(1.21); C328(1.09)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C251(1.14); C108(0.89); C259(1.14); C328(0.97)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C251(1.11); C108(0.77); C259(1.12); C328(0.89)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C251(1.22); C108(0.83); C259(1.22); C328(0.90)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C251(0.92); C108(1.10); C259(0.92); C328(0.95)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C251(1.08); C108(1.00); C259(1.07); C328(0.98)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C251(1.01); C108(0.96); C259(0.99); C328(0.99)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C251(1.08); C108(0.79); C259(1.03); C328(0.99)  LDD0811  [16]
 LDCM0027  Dopamine HEK-293T 4.97  LDD0179  [12]
 LDCM0495  E2913 HEK-293T C687(0.93); C108(0.88); C542(1.01); C426(1.07)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C542(5.68); C687(1.46)  LDD1702  [10]
 LDCM0031  Epigallocatechin gallate HEK-293T 104.51  LDD0183  [12]
 LDCM0625  F8 Ramos C108(0.76); C542(0.92)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C542(1.87)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C108(0.85); C542(7.57)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C542(0.99)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C108(1.06); C542(0.90)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C542(2.27)  LDD2193  [36]
 LDCM0580  Fragment21 Ramos C108(1.07); C542(0.96)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C108(2.01); C542(1.15)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C108(1.01); C542(0.88)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C108(0.90); C542(0.84)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C108(1.44); C542(1.10)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C108(1.25); C542(1.19)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C108(1.15); C542(1.32)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C251(0.95); C259(1.03); C328(0.94); C542(0.91)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos C108(1.24); C542(0.77)  LDD2203  [36]
 LDCM0427  Fragment51 HCT 116 C251(1.05); C259(1.05); C328(1.01); C542(1.34)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C108(1.66); C542(0.66)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C108(1.37); C542(0.67)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C108(1.83); C542(2.10)  LDD2186  [36]
 LDCM0116  HHS-0101 DM93 Y68(0.35); Y79(0.41); Y45(0.77); Y176(0.87)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y68(0.29); Y79(0.58); Y705(0.78); Y45(0.86)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y68(0.56); Y705(0.60); Y176(0.66); Y79(0.71)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y68(0.53); Y705(0.59); Y79(0.66); Y45(1.43)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y79(0.70); Y176(0.73); Y45(0.78); Y68(1.13)  LDD0268  [15]
 LDCM0107  IAA HeLa H131(0.00); H58(0.00); H147(0.00); C251(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y176(5.48)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y176(3.72)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y176(2.61)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y176(14.38)  LDD0288  [14]
 LDCM0128  JWB198 DM93 Y176(0.14)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y176(4.42)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y176(2.51)  LDD0292  [14]
 LDCM0022  KB02 HCT 116 C712(4.63); C718(4.63); C259(6.96); C542(1.45)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C712(2.21); C718(2.21); C259(2.76); C542(1.59)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C712(5.61); C718(5.61); C259(2.52); C542(1.42)  LDD0082  [16]
 LDCM0030  Luteolin HEK-293T 50.36  LDD0182  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C687(0.96)  LDD2102  [10]
 LDCM0109  NEM HeLa H131(0.00); H58(0.00); H81(0.00)  LDD0223  [23]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C687(0.86)  LDD2092  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C687(1.08)  LDD2098  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C251(0.74)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C687(0.70)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C687(1.09)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C687(2.12)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C687(0.69)  LDD2108  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C687(0.75)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C687(0.86)  LDD2115  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C687(1.00)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C367(0.47)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C687(2.99)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C687(1.55)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C687(2.70)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C687(0.70)  LDD2128  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C687(0.94); C251(0.56)  LDD2134  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C687(3.21); C251(0.96)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C367(1.09)  LDD2137  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C687(0.73)  LDD2141  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C687(2.58)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C687(1.05)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C687(0.92)  LDD2148  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C542(0.17)  LDD2206  [37]
 LDCM0032  Oleacein HEK-293T 12.46  LDD0184  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C108(11.62); C542(0.39)  LDD2207  [37]
 LDCM0029  Quercetin HEK-293T 19.80  LDD0181  [12]
 LDCM0090  Rapamycin JHH-7 9.38  LDD0213  [31]
 LDCM0096  SAHA K562 4.50  LDD0269  [8]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [32]
 LDCM0003  Sulforaphane MCF-7 3.08  LDD0042  [11]
 LDCM0021  THZ1 HeLa S3 C259(1.09)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL) Alpha-ketoglutarate dehydrogenase family Q9ULD0
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) Enoyl-CoA hydratase/isomerase family Q13011
Enoyl-CoA hydratase, mitochondrial (ECHS1) Enoyl-CoA hydratase/isomerase family P30084
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) IMPDH/GMPR family P12268
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDK) PDK/BCKDK protein kinase family O14874
Calpain-1 catalytic subunit (CAPN1) Peptidase C2 family P07384
Peroxiredoxin-2 (PRDX2) Peroxiredoxin family P32119
Rho-associated protein kinase 2 (ROCK2) AGC Ser/Thr protein kinase family O75116
Cyclin-dependent kinase 9 (CDK9) CMGC Ser/Thr protein kinase family P50750
Mitogen-activated protein kinase 13 (MAPK13) CMGC Ser/Thr protein kinase family O15264
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) STE Ser/Thr protein kinase family O43318
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) Tyr protein kinase family P07949
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Tyrosine-protein kinase JAK1 (JAK1) Tyr protein kinase family P23458
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Cytoplasmic tyrosine-protein kinase BMX (BMX) Tyr protein kinase family P51813
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
GTP-binding protein Di-Ras3 (DIRAS3) Di-Ras family O95661
Sulfotransferase 2A1 (SULT2A1) Sulfotransferase 1 family Q06520
Guanine nucleotide-binding protein-like 3 (GNL3) TRAFAC class YlqF/YawG GTPase family Q9BVP2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Progesterone receptor (PGR) Nuclear hormone receptor family P06401
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) Nuclear hormone receptor family P22736
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Transcription factor p65 (RELA) . Q04206
Transcription factor SOX-1 (SOX1) . O00570
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Granulocyte colony-stimulating factor receptor (CSF3R) Type I cytokine receptor family Q99062
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein bicaudal D homolog 1 (BICD1) BicD family Q96G01
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Small ribosomal subunit protein mS31 (MRPS31) Mitochondrion-specific ribosomal protein mS31 family Q92665
Small ribosomal subunit protein uS4 (RPS9) Universal ribosomal protein uS4 family P46781
Coronin-1A (CORO1A) WD repeat coronin family P31146
MORC family CW-type zinc finger protein 4 (MORC4) . Q8TE76
Rhombotin-2 (LMO2) . P25791
Sorcin (SRI) . P30626

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acitretin Small molecular drug D05QDC
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Napabucasin . D01IGZ
Phase 2
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atiprimod Small molecular drug D0D9LJ
Golotimod Small molecular drug D02MRN
Nt219 Small molecular drug DUI59O
Wp-1066 Small molecular drug D0IV4C
Glg-801 . D0P7IL
Imx-110 . D0H7DM
Opb-31121 . D0E7IM
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Opb-111077 Small interfering RNA DN81JB
Dsp-0337 Small molecular drug DLJN17
Wp1220 Small molecular drug D3U8YR
Opb-51602 . D01FFC
Tak-114 . D01RCM
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Enmd-1198 Small molecular drug DB05959
Gnf-pf-1399 Small molecular drug D06PZK
Patented
Click To Hide/Show 51 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Curcumin Analog 1 Small molecular drug D0WD1Z
Curcumin Analog 2 Small molecular drug D0IC8O
Flavonoid Derivative 1 Small molecular drug D0V7NH
Flavonoid Derivative 2 Small molecular drug D0Z8BD
Flavonoid Derivative 3 Small molecular drug D0EV5U
Flavonoid Derivative 4 Small molecular drug D0Y3DN
Flavonoid Derivative 5 Small molecular drug D02KDA
Gold-complexed Thiosaccharide Derivative 1 Small molecular drug D0FH4G
Gold-complexed Thiosaccharide Derivative 2 Small molecular drug D03HEP
Gold-complexed Thiosaccharide Derivative 3 Small molecular drug D0J1US
Oxazole Derivative 1 Small molecular drug D0EZ6V
Peptide Analog 7 Small molecular drug D0EW9W
Peptidomimetic Analog 1 Small molecular drug D03VMP
Peptidomimetic Analog 2 Small molecular drug D0QR1I
Peptidomimetic Analog 3 Small molecular drug D02CJU
Peptidomimetic Analog 4 Small molecular drug D0X6QQ
Peptidomimetic Analog 5 Small molecular drug D0XQ3F
Platinum Iv Complexe 1 Small molecular drug D01BVU
Pmid26394986-compound-10 Small molecular drug D0TU0X
Pmid26394986-compound-11 Small molecular drug D02ILH
Pmid26394986-compound-12 Small molecular drug D04GVY
Pmid26394986-compound-13 Small molecular drug D0Y0OQ
Pmid26394986-compound-20 Small molecular drug D08ETA
Pmid26394986-compound-21 Small molecular drug D06RBL
Pmid26394986-compound-22 Small molecular drug D0KP0U
Pmid26394986-compound-42 Small molecular drug D0MA8T
Pmid26394986-compound-43 Small molecular drug D08SEP
Pmid26394986-compound-44 Small molecular drug D09CKU
Pmid26394986-compound-50 Small molecular drug D09BOL
Pmid26394986-compound-51 Small molecular drug D09SYX
Pmid26394986-compound-52 Small molecular drug D0T1GB
Pmid26394986-compound-53 Small molecular drug D0V7HS
Pmid26394986-compound-54 Small molecular drug D0WW1Z
Pmid26394986-compound-figure16 Small molecular drug D0ZQ8T
Pmid26394986-compound-figure17 Small molecular drug D0ZS8Q
Pyrazole Derivative 62 Small molecular drug D0DC3S
Pyrazole Derivative 63 Small molecular drug D0ET3L
Pyrazole Derivative 64 Small molecular drug D0M8OV
Pyrazole Derivative 65 Small molecular drug D0M5AR
Pyrazole Derivative 66 Small molecular drug D0S0UL
Quinoline Carboxamide Derivative 1 Small molecular drug D03XAK
Quinoline Carboxamide Derivative 2 Small molecular drug D00FUZ
Quinoline Carboxamide Derivative 3 Small molecular drug D0D8RR
Salicylic Acid Derivative 1 Small molecular drug D0EX9O
Salicylic Acid Derivative 2 Small molecular drug D0U7LL
Salicylic Acid Derivative 3 Small molecular drug D09ZCV
Salicylic Acid Derivative 4 Small molecular drug D04ANB
Salicylic Acid Derivative 5 Small molecular drug D08EID
Salicylic Acid Derivative 6 Small molecular drug D03ARS
Salicylic Acid Derivative 7 Small molecular drug D0V3PA
Tri-substituted Purine Derivative 1 Small molecular drug D0Y2PO

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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