Marek Group

NFkB - TNF - Autophagy

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Unique sentences: 3

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Details of the model: NFkB - TNF - Autophagy

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ORCID: 0000-0003-1473-370X

  • Name: Marek Ostaszewski
  • Email:
  • Organization: University of Luxembourg
  • Department: Luxembourg Centre for Systems Biomedicine

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Our previous study has demonstrated that inflammatory cytokines, e.g., IFN-gamma and TNF-alpha, induce autophagy in MSCs synergistically by inducing expression of Beclin 1, whereas autophagy, in return, downregulates the immunosuppressive function of MSCs.

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  • Journal: Aging (Albany NY)
  • Journal Impact Factor: 4.696
  • Year: 2012
  • Pubmed Id: 22411934
  • PMC ID: PMC3348477
  • Authors: Antero Salminen Kai Kaarniranta Anu Kauppinen
In the presence of NF-kappaB signaling, TNF-alpha activates mTOR, a major autophagy inhibitor, whereas in cells lacking NF-kappaB activation, TNF-alpha treatment stimulates the expression of Beclin 1, an enhancer of autophagy.

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Our results show that TNF-alpha induces autophagy in vascular smooth muscle A7r5 cell by measuring Beclin1, p62, LC3-II and autophagosome contents.

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Details of the species: Beclin1

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Meta ID: id_1674036342920_0oxri

Details of the species: autophagy

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Meta ID: id_1674036637221_4xonz

Details of the species: TNFalpha

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Meta ID: id_1674036338941_0vohu

Details of the species: NFkB activity

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Meta ID: id_1674036723982_9mto1

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Details of compartment: Cell

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