Relation Results

Summary

Name UNC5
Primary ID SIGNOR-PF98
Type protein family
Formed by UNC5A, UNC5B, UNC5C, UNC5D
Relations 6
Pathways Axon guidance

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Type: Score: Layout: SPV 
0.8480.20.70.5950.8480.478NTN1UNC5DCCChemorepulsion_of_axonNTN4NetrinNTN3

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Relations
Regulator
Mechanism
target
score ℹ
+ NTN1up-regulates activity img/direct-activation.png binding UNC5 0.848
Identifier Residue Sequence Organism Cell Line
SIGNOR-268183 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ UNC5down-regulates activity img/direct_inhibition.png binding DCC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268168 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ UNC5up-regulates img/indirect-activation.png Chemorepulsion_of_axon 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268177 Homo sapiens
pmid sentence
Netrin binding to the receptor deleted in colorectal cancer (DCC) results in attractive responses, viahomodimerization of DCC (covered in detail in later sections), whereas heterodimerization between DCC and receptor uncoordinated locomotion 5 (UNC5) converts this attractive response into repulsion
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ NTN4up-regulates activity img/direct-activation.png binding UNC5 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-268184 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
+ Netrinup-regulates activity img/direct-activation.png binding UNC5 0.848
Identifier Residue Sequence Organism Cell Line
SIGNOR-268174 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ NTN3up-regulates activity img/direct-activation.png binding UNC5 0.478
Identifier Residue Sequence Organism Cell Line
SIGNOR-268185 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
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