Relation Results

Summary

Name Netrin
Primary ID SIGNOR-PF97
Type protein family
Formed by NTN1, NTN3, NTN4
Relations 3
Pathways Axon guidance

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Type: Score: Layout: SPV 
0.20.20.85NetrinDSCAMNEO1UNC5

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Relations
Regulator
Mechanism
target
score ℹ
+ Netrinup-regulates activity img/direct-activation.png binding DSCAM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268173 Mus musculus Spinal Cord
pmid sentence
Here, we report that the Down's syndrome Cell Adhesion Molecule (DSCAM), a candidate gene implicated in the mental retardation phenotype of Down's syndrome, is expressed on spinal commissural axons, binds netrin-1, and is necessary for commissural axons to grow toward and across the midline. DSCAM and DCC can each mediate a turning response of these neurons to netrin-1.
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ Netrinup-regulates activity img/direct-activation.png binding NEO1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268172 Homo sapiens
pmid sentence
In mammals, three secreted netrins, netrin 1, 3 and 4, and two membrane-tethered glycophosphatidylinositol (GPI)-linked (see Glossary, Box 1) netrins, netrin G1 and G2, have been identified. In mammals, receptors for the secreted netrins include deleted in colorectal cancer (DCC), the DCC paralogue neogenin, the UNC-5 homologues UNC5A-D, and Down syndrome cell adhesion molecule (DSCAM).
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ Netrinup-regulates activity img/direct-activation.png binding UNC5 0.85
Identifier Residue Sequence Organism Cell Line
SIGNOR-268174 Homo sapiens
pmid sentence
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists.
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
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