Relation Results

Summary

Name PYG
Primary ID SIGNOR-PF96
Type protein family
Formed by PYGB, PYGL, PYGM
Relations 5
Pathways Glycogenesis, Glycogenolysis

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Type: Score: Layout: SPV 
0.80.3960.80.6720.651PYGglycogenPP1alpha-D-glucose 1-phosphate(2-)PHKG1PHKG2

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Relations
Regulator
Mechanism
target
score ℹ
+ PYGdown-regulates quantity img/direct_inhibition.png chemical modification glycogen 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267953 Homo sapiens
pmid sentence
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenesis, Glycogenolysis
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation PYG 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-267961 Homo sapiens Chang Cell
pmid sentence
GP is the first protein whose function was discovered to be regulated by reversible protein phosphorylation, which is controlled by phosphorylase kinase (PhK) and protein phosphatase 1 (PP1). Here we report that lysine acetylation negatively regulates GP activity by both inhibiting enzyme activity directly and promoting dephosphorylation
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
+ PYGup-regulates quantity img/direct-activation.png chemical modification alpha-D-glucose 1-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267954 Homo sapiens
pmid sentence
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenesis, Glycogenolysis
+ PHKG1up-regulates activity img/direct-activation.png phosphorylation PYG 0.672
Identifier Residue Sequence Organism Cell Line
SIGNOR-267960 Homo sapiens Chang Cell
pmid sentence
It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
+ PHKG2up-regulates activity img/direct-activation.png phosphorylation PYG 0.651
Identifier Residue Sequence Organism Cell Line
SIGNOR-267962 Homo sapiens Chang Cell
pmid sentence
It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
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