Relation Results

Summary

Name ELOVL
Primary ID SIGNOR-PF93
Type protein family
Formed by ELOVL1, ELOVL2, ELOVL3, ELOVL4, ELOVL5, ELOVL6, ELOVL7
Relations 4
Pathways Fatty Acid Synthesis

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Type: Score: Layout: SPV 
0.80.20.80.461ELOVLpalmitoyl-CoAHACD3-hydroxyoctadecanoyl-CoASREBF1

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Relations
Regulator
Mechanism
target
score ℹ
+ ELOVLdown-regulates quantity img/direct_inhibition.png chemical modification palmitoyl-CoA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267901 Homo sapiens
pmid sentence
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle.
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ HACDup-regulates activity img/direct-activation.png binding ELOVL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267915
pmid sentence
Very long-chain fatty acids are produced through a four-step cycle. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases.We also established that the HACD proteins interact with ELOVL proteins. Our analyses have completed the identification of mammalian enzymes responsible for the entire VLCFA elongation cycle.
Publications: 1
Pathways:Fatty Acid Synthesis
+ ELOVLup-regulates quantity img/direct-activation.png chemical modification 3-hydroxyoctadecanoyl-CoA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267902 Homo sapiens
pmid sentence
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle.
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ SREBF1up-regulates quantity by expression img/direct-activation.png transcriptional regulation ELOVL 0.461
Identifier Residue Sequence Organism Cell Line
SIGNOR-267944 Homo sapiens Hep-G2 Cell
pmid sentence
These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c.
Publications: 1 Organism: Homo Sapiens
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