Relation Results

Summary

Name Adenylate_cyclase
Primary ID SIGNOR-PF92
Type protein family
Formed by ADCY1, ADCY10, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9
Relations 12
Pathways Nucleotide Biosynthesis, Oxytocin signaling

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Type: Score: Layout: SPV 
0.5690.6190.4070.7320.80.6190.5790.80.4590.628CAMK2GAdenylate_cyclaseGNAI1NF1GNASATPGNAI2GNAI33',5'-cyclic AMPGNB5GNAL

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CAMK2Gdown-regulates activity img/direct_inhibition.png phosphorylation Adenylate_cyclase 0.569
Identifier Residue Sequence Organism Cell Line
SIGNOR-267845 Ser1076 NVASRMEsTGVMGNI Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. | Site-directed mutagenesis of a CaM kinase II consensus site (Ser-1076 to Ala-1076) in III-AC greatly reduced Ca2+-stimulated phosphorylation and inhibition of III-AC in vivo.
Publications: 1 Organism: Homo Sapiens
+ GNAI1down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.619
Identifier Residue Sequence Organism Cell Line
SIGNOR-267853 Homo sapiens
pmid sentence
Activation of receptors coupled to inhibitory G proteins (Galpha i/o) has opposing consequences for cyclic AMP accumulation and the activity of cyclic AMP-dependent protein kinase, depending on the duration of stimulation. Acute activation inhibits the activity of adenylate cyclase, thereby attenuating cyclic AMP accumulation; in contrast, persistent activation of Galpha i/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase activity, thus increasing cyclic AMP accumulation when the action of the inhibitory receptor is terminated.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ NF1up-regulates img/indirect-activation.png Adenylate_cyclase 0.407
Identifier Residue Sequence Organism Cell Line
SIGNOR-267846 Homo sapiens Neuron
pmid sentence
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation
Identifier Residue Sequence Organism Cell Line
SIGNOR-267847 Homo sapiens Neuron
pmid sentence
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation
Publications: 2 Organism: Homo Sapiens
+ GNASup-regulates activity img/direct-activation.png binding Adenylate_cyclase 0.732
Identifier Residue Sequence Organism Cell Line
SIGNOR-268693 Homo sapiens
pmid sentence
HETEROTRIMERIC G PROTEINS are essential for cell signaling throughout the body. The stimulatory G protein, Gs, couples activation of a host of different transmembrane receptors to adenylyl cyclase stimulation, leading to intracellular generation of cAMP
Identifier Residue Sequence Organism Cell Line
SIGNOR-267848 Homo sapiens
pmid sentence
Because adenylyl cyclases are directly activated by G(s)alpha and the carboxyl termini of the various Galpha proteins determine their receptor coupling specificity, we proposed a set of chimeric G(s)alpha where the COOH-terminal five amino acids are replaced by those of other Galpha proteins and used these to dissect the potential Galpha linked to a given GPCR
Publications: 2 Organism: Homo Sapiens
+ Adenylate_cyclasedown-regulates quantity img/direct_inhibition.png chemical modification ATP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267843 Homo sapiens
pmid sentence
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ GNAI2down-regulates img/direct_inhibition.png binding Adenylate_cyclase 0.619
Identifier Residue Sequence Organism Cell Line
SIGNOR-267849 Homo sapiens
pmid sentence
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required
Publications: 1 Organism: Homo Sapiens
+ GNAI3down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.579
Identifier Residue Sequence Organism Cell Line
SIGNOR-267851 Homo sapiens
pmid sentence
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma)
Publications: 1 Organism: Homo Sapiens
+ Adenylate_cyclaseup-regulates quantity img/direct-activation.png chemical modification 3',5'-cyclic AMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267844 Homo sapiens
pmid sentence
To date, ten different mammalian isoforms of adenylyl cyclase (AC) have been cloned and characterized. Each isoform has its own distinct tissue distribution and regulatory properties, providing possibilities for different cells to respond diversely to similar stimuli. The product of the enzymatic reaction catalyzed by ACs, cyclic AMP (cAMP) has been shown to play a crucial role for a variety of fundamental physiological cell functions ranging from cell growth and differentiation, to transcriptional regulation and apoptosis.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis, Oxytocin signaling
+ GNB5down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.459
Identifier Residue Sequence Organism Cell Line
SIGNOR-267850 Homo sapiens Dopaminergic Neuron
pmid sentence
The D2-class dopamine receptors (D2, D3, and D4) couple to the Gi/o family of G proteins and thus induce inhibition of AC
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ GNALup-regulates activity img/direct-activation.png binding Adenylate_cyclase 0.628
Identifier Residue Sequence Organism Cell Line
SIGNOR-267852 Homo sapiens Dopaminergic Neuron
pmid sentence
D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum.
Publications: 1 Organism: Homo Sapiens
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