Relation Results

Summary

Name Ubiquitin
Primary ID SIGNOR-PF89
Type protein family
Formed by RPS27A, UBA52, UBB, UBC
Relations 14
Pathways MHC class I antigen presentation, Ubiquitin activation

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Type: Score: Layout: SPV 
0.590.20.20.20.8670.8410.20.20.7060.7780.730.20.6350.758PINK1UbiquitinPRKNUb:E2Ub:RBR_E3UCHL3USP5Ubiquitinated-Viral_ProteinUb:RING_E3OTULINUSP7Ub:E1 (UBA6 substrate)Ub:HECT_E3 USP9XUb:E1 (UBA1 substrate)

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PINK1up-regulates img/direct-activation.png phosphorylation Ubiquitin 0.59
Identifier Residue Sequence Organism Cell Line
SIGNOR-270341 Ser65 DYNIQKEsTLHLVLR
pmid sentence
Here we report that ubiquitin is the genuine substrate of PINK1. PINK1 phosphorylated ubiquitin at Ser 65 both in vitro and in cells, and a Ser 65 phosphopeptide derived from endogenous ubiquitin was only detected in cells in the presence of PINK1 and following a decrease in mitochondrial membrane potential.
Publications: 1
+ Ubiquitinup-regulates activity img/direct-activation.png binding PRKN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270343 Mus musculus MEF Cell
pmid sentence
The phosphorylation-dependent interaction between ubiquitin and parkin suggests that phosphorylated ubiquitin unlocks autoinhibition of the catalytic cysteine. Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity. These findings demonstrate that phosphorylated ubiquitin is a parkin activator.
Publications: 1 Organism: Mus Musculus
+ Ubiquitinform complex img/form-complex.png ubiquitination Ub:E2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270839 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ Ubiquitinform complex img/form-complex.png binding Ub:RBR_E3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271381 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner to form a thioester-linked E1‒Ub conjugate. The activated Ub is then delivered to an E2 enzyme via a transthiolation reaction. Finally, an E3 enzyme, which can bind both a substrate and an E2‒Ub conjugate, mediates the covalent linkage of Ub to the target protein as a tag.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ UCHL3up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.867
Identifier Residue Sequence Organism Cell Line
SIGNOR-270832 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP5up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.841
Identifier Residue Sequence Organism Cell Line
SIGNOR-270830 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ Ubiquitinform complex img/form-complex.png binding Ubiquitinated-Viral_Protein 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267766 Homo sapiens
pmid sentence
MHC class I antigen presentation pathway. Proteins with ubiquitin tags (red spheres) are degraded by proteasomes and the resulting peptides are transported into the endoplasmic reticulum (ER) by TAP|Many viruses have mechanisms of interfering with MHC class I processing, including direct interaction of viral proteins with immunoproteasome subunits.
Publications: 1 Organism: Homo Sapiens
+ Ubiquitinform complex img/form-complex.png binding Ub:RING_E3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271380 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner to form a thioester-linked E1‒Ub conjugate. The activated Ub is then delivered to an E2 enzyme via a transthiolation reaction. Finally, an E3 enzyme, which can bind both a substrate and an E2‒Ub conjugate, mediates the covalent linkage of Ub to the target protein as a tag.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ OTULINup-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.706
Identifier Residue Sequence Organism Cell Line
SIGNOR-270829 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP7up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.778
Identifier Residue Sequence Organism Cell Line
SIGNOR-270837 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ Ubiquitinform complex img/form-complex.png binding Ub:E1 (UBA6 substrate) 0.73
Identifier Residue Sequence Organism Cell Line
SIGNOR-270836 Homo sapiens
pmid sentence
The activation of ubiquitin by the ubiquitin-activating enzyme Uba1 (E1) constitutes the first step in the covalent modification of target proteins with ubiquitin. This activation is a three-step process in which ubiquitin is adenylated at its C-terminal glycine, followed by the covalent attachment of ubiquitin to a catalytic cysteine residue of Uba1 and the subsequent adenylation of a second ubiquitin.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ Ubiquitinform complex img/form-complex.png binding Ub:HECT_E3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271379 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner to form a thioester-linked E1‒Ub conjugate. The activated Ub is then delivered to an E2 enzyme via a transthiolation reaction. Finally, an E3 enzyme, which can bind both a substrate and an E2‒Ub conjugate, mediates the covalent linkage of Ub to the target protein as a tag.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP9Xup-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.635
Identifier Residue Sequence Organism Cell Line
SIGNOR-270831 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ Ubiquitinform complex img/form-complex.png binding Ub:E1 (UBA1 substrate) 0.758
Identifier Residue Sequence Organism Cell Line
SIGNOR-270834 Homo sapiens
pmid sentence
The activation of ubiquitin by the ubiquitin-activating enzyme Uba1 (E1) constitutes the first step in the covalent modification of target proteins with ubiquitin. This activation is a three-step process in which ubiquitin is adenylated at its C-terminal glycine, followed by the covalent attachment of ubiquitin to a catalytic cysteine residue of Uba1 and the subsequent adenylation of a second ubiquitin.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
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