Relation Results

Summary

Name HACD
Primary ID SIGNOR-PF86
Type protein family
Formed by HACD1, HACD2, HACD3, HACD4
Relations 4
Pathways Fatty Acid Synthesis

Viewer

Type: Score: Layout: SPV 
0.20.80.20.8HACDFASNvery long-chain 2,3-trans-enoyl CoA(4-)ELOVLvery long-chain (R)-3-hydroxyacyl-CoA(4-)

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ HACDup-regulates activity img/direct-activation.png chemical activation FASN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267764 Homo sapiens
pmid sentence
Very long-chain fatty acids are produced through a four-step cycle. However, the 3-hydroxyacyl-CoA dehydratase catalyzing the third step in mammals has remained unidentified. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases,
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ HACDup-regulates quantity img/direct-activation.png chemical modification very long-chain 2,3-trans-enoyl CoA(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267918 Homo sapiens
pmid sentence
Very long-chain fatty acids are produced through a four-step cycle. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases.We also established that the HACD proteins interact with ELOVL proteins. Our analyses have completed the identification of mammalian enzymes responsible for the entire VLCFA elongation cycle.
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ HACDup-regulates activity img/direct-activation.png binding ELOVL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267915
pmid sentence
Very long-chain fatty acids are produced through a four-step cycle. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases.We also established that the HACD proteins interact with ELOVL proteins. Our analyses have completed the identification of mammalian enzymes responsible for the entire VLCFA elongation cycle.
Publications: 1
Pathways:Fatty Acid Synthesis
+ HACDdown-regulates quantity img/direct_inhibition.png chemical modification very long-chain (R)-3-hydroxyacyl-CoA(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267917 Homo sapiens
pmid sentence
Very long-chain fatty acids are produced through a four-step cycle. Mammals have four candidates, HACD1-4, based on sequence similarities to the recently identified yeast Phs1, although HACD3 and HACD4 share relatively weak similarity. We demonstrate that all four of these human proteins are indeed 3-hydroxyacyl-CoA dehydratases.We also established that the HACD proteins interact with ELOVL proteins. Our analyses have completed the identification of mammalian enzymes responsible for the entire VLCFA elongation cycle.
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
a simple tooltip