Relation Results

Summary

Name THR
Primary ID SIGNOR-PF84
Type protein family
Formed by THRA, THRB
Relations 34
Pathways Thyroid Hormone Metabolism

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Type: Score: Layout: SPV 
0.3780.5180.7160.3990.80.6430.80.3950.80.4250.20.4310.20.20.20.4250.2NR0B2THRRARARXRARARBD-thyroxineRXRBL-thyroxineRARG3,3',5'-triiodothyronineMAPK1TRIP11GATA2MAPK3ASXL3

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Relations
Regulator
Mechanism
target
score ℹ
+ NR0B2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation THR 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-267806 Homo sapiens
pmid sentence
Shp (short heterodimer partner) is an orphan nuclear receptor lacking a dna binding domain that interacts with nuclear receptors (nr) including thyroid receptor (tr), retinoic acid receptors (rar and rxr), and estrogen receptors alpha and beta (eralpha and erbeta). Shp acts as a negative regulator of these receptors by inhibiting dna binding and transcriptional activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270298 Homo sapiens
pmid sentence
Shp (short heterodimer partner) is an orphan nuclear receptor lacking a dna binding domain that interacts with nuclear receptors (nr) including thyroid receptor (tr), retinoic acid receptors (rar and rxr), and estrogen receptors alpha and beta (eralpha and erbeta). Shp acts as a negative regulator of these receptors by inhibiting dna binding and transcriptional activation.
Publications: 2 Organism: Homo Sapiens
+ RARAup-regulates img/direct-activation.png binding THR 0.518
Identifier Residue Sequence Organism Cell Line
SIGNOR-270293 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ RXRAup-regulates img/direct-activation.png binding THR 0.716
Identifier Residue Sequence Organism Cell Line
SIGNOR-270292 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr).
Identifier Residue Sequence Organism Cell Line
SIGNOR-269877 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr).
Publications: 2 Organism: Homo Sapiens
+ RARBup-regulates activity img/direct-activation.png binding THR 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-267807 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ D-thyroxineup-regulates activity img/direct-activation.png chemical activation THR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267802 Homo sapiens Thyroid Epithelial Cell
pmid sentence
The high levels of circulating D-T4 and presumably of circulating D-T3 originating from the peripheral conversion of D-T4 achieved after the chronic administration of D-T4 (Choloxin) may be responsible for a high degree of saturation of the human pituitary nuclear T3 receptors, thus resulting in the suppression of the TRH-induced TSH response.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269878 Homo sapiens Thyroid Epithelial Cell
pmid sentence
The high levels of circulating D-T4 and presumably of circulating D-T3 originating from the peripheral conversion of D-T4 achieved after the chronic administration of D-T4 (Choloxin) may be responsible for a high degree of saturation of the human pituitary nuclear T3 receptors, thus resulting in the suppression of the TRH-induced TSH response.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270294 Homo sapiens Thyroid Epithelial Cell
pmid sentence
The high levels of circulating D-T4 and presumably of circulating D-T3 originating from the peripheral conversion of D-T4 achieved after the chronic administration of D-T4 (Choloxin) may be responsible for a high degree of saturation of the human pituitary nuclear T3 receptors, thus resulting in the suppression of the TRH-induced TSH response.
Publications: 3 Organism: Homo Sapiens
+ RXRAup-regulates activity img/direct-activation.png binding THR 0.716
Identifier Residue Sequence Organism Cell Line
SIGNOR-267800 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr).
Publications: 1 Organism: Homo Sapiens
+ RXRBup-regulates img/direct-activation.png binding THR 0.643
Identifier Residue Sequence Organism Cell Line
SIGNOR-269880 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr
Identifier Residue Sequence Organism Cell Line
SIGNOR-270297 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr
Publications: 2 Organism: Homo Sapiens
+ L-thyroxineup-regulates activity img/direct-activation.png chemical activation THR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270300 Rattus norvegicus Liver
pmid sentence
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267808 Rattus norvegicus Liver
pmid sentence
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269881 Rattus norvegicus Liver
pmid sentence
We determined the affinity for T3 and analog binding characteristics of the translational products of c-erbA a- and /3-probes together with hepatic nuclear extracts.
Publications: 3 Organism: Rattus Norvegicus
Pathways:Thyroid Hormone Metabolism
+ RARGup-regulates activity img/direct-activation.png binding THR 0.395
Identifier Residue Sequence Organism Cell Line
SIGNOR-267804 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png binding THR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267276 Homo sapiens
pmid sentence
T3 binds its receptor (TR) in the nucleus. TRs are ligand-dependent transcription factors belonging to the type II group of NHRs. TRs are encoded by two genes, Thra and Thrb.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ MAPK1down-regulates activity img/direct_inhibition.png phosphorylation THR 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-270303 Homo sapiens
pmid sentence
We concluded that serine 142 of the tr dbd is the likely site of phosphorylation by t(4)-activated mapk and that the docking site on tr for activated mapk includes residues 128-133 (kgffrr), a basic amino acid-enriched motif novel for mapk substrates. Tr mutations in the proposed mapk docking domain and at residue 142 modulated t(4)-conditioned shedding of co-repressor and recruitment of co-activator proteins by the receptor, and they altered transcriptional activity of tr in a thyroid hormone response element-luciferase reporter assay.
Publications: 1 Organism: Homo Sapiens
+ THRup-regulates activity img/direct-activation.png binding RARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267781 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ RXRBup-regulates activity img/direct-activation.png binding THR 0.643
Identifier Residue Sequence Organism Cell Line
SIGNOR-267805 Homo sapiens
pmid sentence
Like many receptors belonging to the superfamily of steroid/thyroid nuclear receptors, thyroid hormone receptors (trs) bind to specific th-dna responsive elements (tre) upstream of target gene in heterodimeric complex with the 9-cis retinoid acid receptor (rxr
Publications: 1 Organism: Homo Sapiens
+ TRIP11up-regulates img/direct-activation.png binding THR 0.431
Identifier Residue Sequence Organism Cell Line
SIGNOR-270295 Homo sapiens
pmid sentence
Trip230 binds to rb independently of thyroid hormone while it forms a complex with tr in a thyroid hormone-dependent manner. Ectopic expression of the protein trip230 in cells, but not a mutant form that does not bind to tr, enhances specifically tr-dependent transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269879 Homo sapiens
pmid sentence
Trip230 binds to rb independently of thyroid hormone while it forms a complex with tr in a thyroid hormone-dependent manner. Ectopic expression of the protein trip230 in cells, but not a mutant form that does not bind to tr, enhances specifically tr-dependent transcriptional activity.
Publications: 2 Organism: Homo Sapiens
+ RARGup-regulates img/direct-activation.png binding THR 0.395
Identifier Residue Sequence Organism Cell Line
SIGNOR-270296 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ TRIP11up-regulates activity img/direct-activation.png binding THR 0.431
Identifier Residue Sequence Organism Cell Line
SIGNOR-267803 Homo sapiens
pmid sentence
Trip230 binds to rb independently of thyroid hormone while it forms a complex with tr in a thyroid hormone-dependent manner. Ectopic expression of the protein trip230 in cells, but not a mutant form that does not bind to tr, enhances specifically tr-dependent transcriptional activity.
Publications: 1 Organism: Homo Sapiens
+ THRup-regulates activity img/direct-activation.png binding RARB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267780 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ THRup-regulates activity img/direct-activation.png binding RARA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267779 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ THRdown-regulates activity img/direct_inhibition.png binding GATA2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267275 Homo sapiens
pmid sentence
We found that the T3-bound TR inhibits this reporter construct driven by GATA2 alone, indicating that the target of T3-bound TR repression is GATA2.
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
Pathways:Thyroid Hormone Metabolism
+ THRup-regulates img/direct-activation.png binding RARA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270313 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ THRup-regulates img/direct-activation.png binding RARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270315 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ MAPK3down-regulates activity img/direct_inhibition.png phosphorylation THR 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-270301 Homo sapiens
pmid sentence
We concluded that serine 142 of the tr dbd is the likely site of phosphorylation by t(4)-activated mapk and that the docking site on tr for activated mapk includes residues 128-133 (kgffrr), a basic amino acid-enriched motif novel for mapk substrates. Tr mutations in the proposed mapk docking domain and at residue 142 modulated t(4)-conditioned shedding of co-repressor and recruitment of co-activator proteins by the receptor, and they altered transcriptional activity of tr in a thyroid hormone response element-luciferase reporter assay.
Publications: 1 Organism: Homo Sapiens
+ RARBup-regulates img/direct-activation.png binding THR 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-270299 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ THRup-regulates img/direct-activation.png binding RARB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270314 Homo sapiens
pmid sentence
Ee report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs
Publications: 1 Organism: Homo Sapiens
+ ASXL3down-regulates activity img/direct_inhibition.png binding THR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270302 Homo sapiens HEP-3B Cell
pmid sentence
We determined that ASXL3 depletion augments the ligand-induced transcriptional activities of LXRα and TRβ, which were repressed by ASXL3 overexpression. The ligand-dependent interactions of ASXL3 with LXRα and TRβ were demonstrated by the GST pull-down and immunoprecipitation analyses. We confirmed that ASXL3 suppresses the expression of LXRα target genes through its recruitment to the LXR-response elements.
Publications: 1 Organism: Homo Sapiens
+ RARAup-regulates activity img/direct-activation.png binding THR 0.518
Identifier Residue Sequence Organism Cell Line
SIGNOR-267801 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
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