Relation Results

Summary

Name DIO
Primary ID SIGNOR-PF83
Type protein family
Formed by DIO1, DIO2, DIO3
Relations 19

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Type: Score: Layout: SPV 
0.80.80.3840.80.20.260.80.80.80.20.3470.80.20.20.86-propyl-2-thiouracilDIOL-thyroxineUBE2J13,3',5'-triiodothyronineIFNGTNF3,3'-diiodothyronine3',5'-cyclic AMPUBE2G2FOXO33,3',5'-triiodo-L-thyronineMYOD1IL1Biodide

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Relations
Regulator
Mechanism
target
score ℹ
+ 6-propyl-2-thiouracildown-regulates activity img/direct_inhibition.png chemical inhibition DIO 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270240 Homo sapiens
pmid sentence
The activity of D1 but not D2 or D3 is inhibited by 6n-propylthiouracil (PTU).
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
+ DIOdown-regulates quantity img/direct_inhibition.png chemical modification L-thyroxine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267043 Homo sapiens
pmid sentence
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule. 
Publications: 1 Organism: Homo Sapiens
+ UBE2J1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIO 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-270242 Homo sapiens
pmid sentence
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244.
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
+ DIOup-regulates quantity img/direct-activation.png chemical modification 3,3',5'-triiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267809 Homo sapiens
pmid sentence
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4)
Identifier Residue Sequence Organism Cell Line
SIGNOR-267044 Homo sapiens
pmid sentence
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule. 
Publications: 2 Organism: Homo Sapiens
+ IFNGdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270238 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267810 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b.
Publications: 2 Organism: Rattus Norvegicus
+ TNFdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-270239 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267811 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b.
Publications: 2 Organism: Rattus Norvegicus
+ DIOup-regulates quantity img/direct-activation.png small molecule catalysis 3,3'-diiodothyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270307 Homo sapiens COS Cell
pmid sentence
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144.
Publications: 1 Organism: Homo Sapiens
+ 3',5'-cyclic AMPup-regulates quantity by expression img/indirect-activation.png DIO 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270243 Homo sapiens
pmid sentence
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity.
Publications: 1 Organism: Homo Sapiens
+ 3,3',5'-triiodothyronineup-regulates activity img/direct-activation.png chemical activation DIO 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270246 Homo sapiens COS Cell
pmid sentence
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine deiodinases, D3 protein contains selenocysteine (SeC) in the highly conserved core catalytic center at amino acid position 144.
Publications: 1 Organism: Homo Sapiens
+ UBE2G2down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270244 Homo sapiens
pmid sentence
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244.
Publications: 1 Organism: Homo Sapiens
Tissue: Thyroid Gland
+ FOXO3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DIO 0.347
Identifier Residue Sequence Organism Cell Line
SIGNOR-270245
pmid sentence
Forkhead box O3 (FoxO3) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, FoxO3-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3.
Publications: 1
+ DIOup-regulates quantity img/direct-activation.png small molecule catalysis 3,3',5'-triiodo-L-thyronine 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270305
pmid sentence
The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4)
Publications: 1
+ DIOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270306 Homo sapiens
pmid sentence
The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4). Here we show that type 2 deiodinase (D2) is essential for normal mouse myogenesis and muscle regeneration. Indeed, D2-mediated increases in T3 were essential for the enhanced transcription of myogenic differentiation 1 (MyoD) and for execution of the myogenic program.
Publications: 1 Organism: Homo Sapiens
+ IL1Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270241 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells. These include TNF-a, IL-lb and INF-y.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267812 Rattus norvegicus
pmid sentence
From the results in Figs. 1-3, it is clear that several cytokines reduce the expression of 5’-DI mRNA and enzymatic activity in FRTL-5 cells grown in TSH-containing medium. These include TNF-a, IL-lb and INF-g but not TGF-b.
Publications: 2 Organism: Rattus Norvegicus
+ DIOup-regulates quantity img/direct-activation.png chemical modification iodide 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267045 Homo sapiens
pmid sentence
Thyroid hormone (TH) deiodinases play a pivotal role in the functional diversification of TH signaling. They are involved in development, growth, and metabolic processes, and act in a cell-specific manner in the fine regulation of TH homeostasis. TH deiodinases catalyze activation and inactivation of THs through the removal of one iodine atom in the outer or inner ring of the TH molecule. 
Publications: 1 Organism: Homo Sapiens
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