Relation Results

Summary

Name G6P
Primary ID SIGNOR-PF81
Type protein family
Formed by G6PC1, G6PC2, G6PC3
Relations 18
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.20.20.260.20.20.2820.3260.80.80.20.8NR0B2G6PNR3C1HNF4ACREB1PRKAA1CRTC2FOXO1metforminalpha-D-glucose 6-phosphate(2-)FOXOα-D-glucose

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Relations
Regulator
Mechanism
target
score ℹ
+ NR0B2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267791 Homo sapiens
pmid sentence
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-270256 Homo sapiens
pmid sentence
As shown in fig. 3a, metformin (0.5 to 2 mmol/l) induced shp gene expression and repressed the camp/dex-induced expression of pepck and g6pase in a dose-dependent manner in h4iie cells
Publications: 2 Organism: Homo Sapiens
+ NR3C1up-regulates quantity img/direct-activation.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270258 Pongo pygmaeus HeLa Cell
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Identifier Residue Sequence Organism Cell Line
SIGNOR-267792 Homo sapiens
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Publications: 2 Organism: Pongo Pygmaeus, Homo Sapiens
+ HNF4Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.26
Identifier Residue Sequence Organism Cell Line
SIGNOR-270255 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267790 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Publications: 2 Organism: Homo Sapiens
+ CREB1up-regulates quantity img/direct-activation.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267786 Homo sapiens
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Identifier Residue Sequence Organism Cell Line
SIGNOR-270250 Pongo pygmaeus HeLa Cell
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Publications: 2 Organism: Homo Sapiens, Pongo Pygmaeus
+ PRKAA1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270257 Homo sapiens
pmid sentence
Collectively, these findings suggest ampk suppresses glucose production through two transcriptional effects:reduced expression of creb targets via crtc inactivation and reduced expression of foxo target genes via class iia hdac inactivation
Publications: 1 Organism: Homo Sapiens
+ CRTC2up-regulates quantity img/direct-activation.png transcriptional regulation G6P 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-267788 Homo sapiens
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Identifier Residue Sequence Organism Cell Line
SIGNOR-270253 Pongo pygmaeus HeLa Cell
pmid sentence
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB
Publications: 2 Organism: Homo Sapiens, Pongo Pygmaeus
Pathways:Glycolysis and Gluconeogenesis
+ FOXO1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.326
Identifier Residue Sequence Organism Cell Line
SIGNOR-270251 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267787 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Publications: 2 Organism: Homo Sapiens
+ metforminup-regulates quantity by expression img/indirect-activation.png G6P 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270254 Homo sapiens
pmid sentence
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267789 Homo sapiens
pmid sentence
In this study, we found that metformin increased shp gene expression via ampk activation and inhibited the expression of the hepatic gluconeogenic genes pepck and g6pase via upregulation of shp.
Publications: 2 Organism: Homo Sapiens
+ G6Pdown-regulates quantity img/direct_inhibition.png chemical modification alpha-D-glucose 6-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266571 Homo sapiens
pmid sentence
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270252 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Publications: 1 Organism: Homo Sapiens
+ G6Pup-regulates quantity img/direct-activation.png chemical modification α-D-glucose 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266567 Homo sapiens
pmid sentence
Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in G6Pase becomes phosphorylated generating an enzyme-phosphate intermediate. Glucose-6-phosphatase (G6Pase,1 EC 3.1.3.9), a key enzyme in glucose homeostasis, catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and phosphate, the terminal steps in gluconeogenesis and glycogenolysis
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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