Relation Results

Summary

Name PK
Primary ID SIGNOR-PF80
Type protein family
Formed by PKLR, PKM
Relations 21
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.20.2520.4460.3970.3780.80.3390.80.80.80.8PKSTAT3CREB1EGLN3HIF-1 complexPIM2L-serineSREBF1AlkanninphosphonatoenolpyruvateShikoninpyruvate

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PKup-regulates img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268152 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Pkm2 activates transcription of mek5 by phosphorylating stat3 at y705. pkm2 regulates mek5 transcription via activation of stat3
Publications: 1 Organism: Homo Sapiens
+ CREB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PK 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-270285 Homo sapiens
pmid sentence
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1
Identifier Residue Sequence Organism Cell Line
SIGNOR-268145 Homo sapiens
pmid sentence
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1
Identifier Residue Sequence Organism Cell Line
SIGNOR-268144 Homo sapiens
pmid sentence
In fasted mammals, glucose homeostasis is maintained through induction of the camp response element-binding protein (creb) coactivator transducer of regulated creb activity 2 (torc2), which stimulates the gluconeogenic program in concert with the forkhead factor foxo1
Publications: 3 Organism: Homo Sapiens
+ EGLN3up-regulates activity img/direct-activation.png hydroxylation PK 0.446
Identifier Residue Sequence Organism Cell Line
SIGNOR-268146 Homo sapiens HeLa Cell
pmid sentence
Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1α and PKM2 coactivator function. Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxylation on proline-403/408. PHD3 knockdown inhibits PKM2 coactivator function, reduces glucose uptake and lactate production, and increases O(2) consumption in cancer cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270290 Homo sapiens HeLa Cell
pmid sentence
Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1α and PKM2 coactivator function. Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxylation on proline-403/408. PHD3 knockdown inhibits PKM2 coactivator function, reduces glucose uptake and lactate production, and increases O(2) consumption in cancer cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268147 Homo sapiens HeLa Cell
pmid sentence
Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1α and PKM2 coactivator function. Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxylation on proline-403/408. PHD3 knockdown inhibits PKM2 coactivator function, reduces glucose uptake and lactate production, and increases O(2) consumption in cancer cells.
Publications: 3 Organism: Homo Sapiens
+ PKup-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268149 in vitro
pmid sentence
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor
Identifier Residue Sequence Organism Cell Line
SIGNOR-270312 in vitro
pmid sentence
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor
Publications: 2 Organism: In Vitro
+ PKup-regulates activity img/direct-activation.png binding HIF-1 complex 0.397
Identifier Residue Sequence Organism Cell Line
SIGNOR-270311 Homo sapiens HeLa Cell
pmid sentence
PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements,
Identifier Residue Sequence Organism Cell Line
SIGNOR-268150 Homo sapiens HeLa Cell
pmid sentence
PKM2 interacts directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements,
Publications: 2 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ PIM2down-regulates activity img/direct_inhibition.png phosphorylation PK 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-268148 Homo sapiens HEK-293 Cell
pmid sentence
Here, we identified the protein-serine/threonine kinase PIM2, a known oncogene, as a novel binding partner of PKM2. The interaction between PIM2 and PKM2 was confirmed by multiple biochemical approaches in vitro and in cultured cells. Importantly, we found that PIM2 could directly phosphorylate PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels. Compared with wild type, PKM2 with the phosphorylation-defective mutation displayed a reduced effect on glycolysis
Publications: 1 Organism: Homo Sapiens
+ L-serineup-regulates activity img/direct-activation.png chemical activation PK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270286 Homo sapiens
pmid sentence
We show that serine can bind to and activate human PKM2, and that PKM2 activity in cells is reduced in response to serine deprivation.
Publications: 1 Organism: Homo Sapiens
+ PIM2up-regulates quantity by stabilization img/direct-activation.png phosphorylation PK 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-270287 Homo sapiens
pmid sentence
Importantly, we found that PIM2 could directly phosphorylate PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268151 Homo sapiens
pmid sentence
Importantly, we found that PIM2 could directly phosphorylate PKM2 on the Thr-454 residue, resulting in an increase of PKM2 protein levels.
Publications: 2 Organism: Homo Sapiens
+ SREBF1up-regulates quantity by expression img/direct-activation.png transcriptional regulation PK 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-267799 Homo sapiens
pmid sentence
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk)
Identifier Residue Sequence Organism Cell Line
SIGNOR-270288 Homo sapiens
pmid sentence
Well-described targets of srebp-1 and the carbohydrate response element binding protein (chrebp), which include the following: fatty acid synthase (fas), acetyl coa carboxylase (acc1), and liver pyruvate kinase (l-pk)
Publications: 2 Organism: Homo Sapiens
+ Alkannindown-regulates activity img/direct_inhibition.png chemical inhibition PK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270284 Homo sapiens MCF-7 Cell, A-549 Cell
pmid sentence
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. |Shikonin and alkannin are potent inhibitors of recombinant human PKM2|Shikonin and alkannin significantly inhibited the glycolytic rate, as manifested by cellular lactate production and glucose consumption in drug-sensitive and resistant cancer cell lines (MCF-7, MCF-7/Adr, MCF-7/Bcl-2, MCF-7/Bcl-x(L) and A549) that primarily express PKM2.
Publications: 1 Organism: Homo Sapiens
+ PKdown-regulates quantity img/direct_inhibition.png chemical modification phosphonatoenolpyruvate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266539 Homo sapiens
pmid sentence
Pyruvate kinase (PK)1 is an important regulatory enzyme that is able to generate ATP under hypoxic conditions as well as regulate glucose consumption. Pyruvate kinase catalyzes the last step in glycolysis converting the substrate phosphoenolpyruvate (PEP) into pyruvate, while producing one molecule of ATP per reaction per cycle (Figure 1A).
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ Shikonindown-regulates activity img/direct_inhibition.png chemical inhibition PK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270289 Homo sapiens MCF-7 Cell, A-549 Cell
pmid sentence
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. |Shikonin and alkannin are potent inhibitors of recombinant human PKM2|Shikonin and alkannin significantly inhibited the glycolytic rate, as manifested by cellular lactate production and glucose consumption in drug-sensitive and resistant cancer cell lines (MCF-7, MCF-7/Adr, MCF-7/Bcl-2, MCF-7/Bcl-x(L) and A549) that primarily express PKM2.
Publications: 1 Organism: Homo Sapiens
+ PKup-regulates quantity img/direct-activation.png chemical modification pyruvate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266540 Homo sapiens
pmid sentence
Pyruvate kinase (PK)1 is an important regulatory enzyme that is able to generate ATP under hypoxic conditions as well as regulate glucose consumption. Pyruvate kinase catalyzes the last step in glycolysis converting the substrate phosphoenolpyruvate (PEP) into pyruvate, while producing one molecule of ATP per reaction per cycle (Figure 1A).
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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