Relation Results

Summary

Name PFK
Primary ID SIGNOR-PF79
Type protein family
Formed by PFKL, PFKM, PFKP
Relations 7
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.80.3350.80.20.80.3520.8beta-D-fructofuranose 2,6-bisphosphatePFKMYCcitrate(3-)OGAbeta-D-fructofuranose 1,6-bisphosphate(4-)OGTβ-D-fructose 6-phosphate

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Relations
Regulator
Mechanism
target
score ℹ
+ beta-D-fructofuranose 2,6-bisphosphateup-regulates activity img/direct-activation.png binding PFK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267262 Homo sapiens
pmid sentence
The PFKFB enzymes synthesize fructose-2,6-bisphosphate (F2,6BP) which allosterically activates 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in the glycolytic pathway. PFK-1 is inhibited by ATP when energy stores are abundant and F2,6BP can override this inhibition and enhance glucose uptake and glycolytic flux
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ MYCup-regulates quantity by expression img/direct-activation.png transcriptional regulation PFK 0.335
Identifier Residue Sequence Organism Cell Line
SIGNOR-267587 Rattus norvegicus
pmid sentence
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway.
Publications: 1 Organism: Rattus Norvegicus
+ citrate(3-)down-regulates activity img/direct_inhibition.png binding PFK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267579 Homo sapiens
pmid sentence
Once in the cytoplasm, citrate is able to inhibit phosphofructokinase 1 (PFK1) [4], the enzyme that is in charge of the “committed” step in glycolysis and converts fructose-6-phosphate to fructose-1, 6-bisphosphate (Fig. 1). In addition, citrate can inhibit PFK2, a bifunctional enzyme that regulates the rates of glycolysis and gluconeogenesis. Thus, a high level of citrate can lead to the reduction of glycolysis by directly inhibiting PFK1 and PFK2 and indirectly inhibiting PK.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ OGAup-regulates activity img/direct-activation.png deglycosylation PFK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267609 Homo sapiens
pmid sentence
Our previous investigation on O-GlcNAcylation of PFK1 has demonstrated that O-GlcNAcylation inhibits PFK1 enzyme activity|In cells, a single set of antagonistic enzymes-O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase are responsible for the addition and removal of GlcNAc moiety, respectively.
Publications: 1 Organism: Homo Sapiens
+ PFKup-regulates quantity img/direct-activation.png chemical modification beta-D-fructofuranose 1,6-bisphosphate(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266474 Homo sapiens
pmid sentence
Phosphofructokinase catalyzes the rate-limiting, ATP-mediated phosphorylation of F6P to FBP. PFK is a homo- or heterotetramer with a molecular mass of approximately 380 kDa, and the enzyme is allosterically regulated, among other metabolites, by 2,3-DPG.35.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ OGTdown-regulates activity img/direct_inhibition.png glycosylation PFK 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-267586 Homo sapiens HEK-293 Cell
pmid sentence
O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway| O-GlcNAc transferase (OGT) catalyzes the transfer of N-acetylglucosamine from uridine diphospho-N-acetylglucosamine (UDP-GlcNAc) to serine or threonine residues
Publications: 1 Organism: Homo Sapiens
+ PFKdown-regulates quantity img/direct_inhibition.png chemical modification β-D-fructose 6-phosphate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266470 Homo sapiens
pmid sentence
Phosphofructokinase catalyzes the rate-limiting, ATP-mediated phosphorylation of F6P to FBP. PFK is a homo- or heterotetramer with a molecular mass of approximately 380 kDa, and the enzyme is allosterically regulated, among other metabolites, by 2,3-DPG.35.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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