Relation Results

Summary

Name PGAM
Primary ID SIGNOR-PF78
Type protein family
Formed by PGAM1, PGAM2
Relations 5
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.20.3290.2830.80.8PAK1PGAMPKN1SIRT22-phosphonato-D-glycerate(3-)3-phosphonato-D-glycerate(3-)

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Relations
Regulator
Mechanism
target
score ℹ
+ PAK1down-regulates img/direct_inhibition.png phosphorylation PGAM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270283 Homo sapiens Neutrophil
pmid sentence
Activated pak1 inhibits glycolysis by association of its catalytic domain with pgam-b and subsequent phosphorylation of the enzyme on serine residues 23 and 118, thereby abolishing pgam activity.
Publications: 1 Organism: Homo Sapiens
+ PKN1down-regulates img/direct_inhibition.png phosphorylation PGAM 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-270282 Homo sapiens Neutrophil
pmid sentence
Activated pak1 inhibits glycolysis by association of its catalytic domain with pgam-b and subsequent phosphorylation of the enzyme on serine residues 23 and 118, thereby abolishing pgam activity.
Publications: 1 Organism: Homo Sapiens
+ SIRT2up-regulates activity img/direct-activation.png deacetylation PGAM 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-266519 Homo sapiens
pmid sentence
Here we report that PGAM is acetylated at lysine 100 (K100), an active site residue that is invariably conserved from bacteria, to yeast, plant, and mammals. K100 acetylation is detected in fly, mouse, and human cells and in multiple tissues and decreases PGAM2 activity. The cytosolic protein deacetylase sirtuin 2 (SIRT2) deacetylates and activates PGAM2.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ PGAMup-regulates quantity img/direct-activation.png chemical modification 2-phosphonato-D-glycerate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266516 Homo sapiens
pmid sentence
Phosphoglycerate mutase (PGAM) is a glycolytic enzyme that catalyzes the reversible conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG; ref. 4). Human genome contains two PGAM genes, PGAM1 (also known as PGAM-B), which is expressed in brain and most other tissues, and PGAM2 (also known as PGAM-M), which is highly expressed in muscle.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ PGAMdown-regulates quantity img/direct_inhibition.png chemical modification 3-phosphonato-D-glycerate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266513 Homo sapiens
pmid sentence
Phosphoglycerate mutase (PGAM) is a glycolytic enzyme that catalyzes the reversible conversion of 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG; ref. 4). Human genome contains two PGAM genes, PGAM1 (also known as PGAM-B), which is expressed in brain and most other tissues, and PGAM2 (also known as PGAM-M), which is highly expressed in muscle.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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