Relation Results

Summary

Name PKG
Primary ID SIGNOR-PF77
Type protein family
Formed by PGK1, PGK2
Relations 3
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.80.4810.8PKG3-phosphonato-D-glyceroyl phosphate(4-)HIF1A3-phosphonato-D-glycerate(3-)

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Relations
Regulator
Mechanism
target
score ℹ
+ PKGdown-regulates quantity img/direct_inhibition.png chemical modification 3-phosphonato-D-glyceroyl phosphate(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266504 Homo sapiens
pmid sentence
Phosphoglycerate kinase generates one molecule of ATP by catalyzing the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. Two isozymes of PGK exist: PGK-1, ubiquitously expressed in all somatic cells, and PGK-2, expressed only in spermatozoa.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ HIF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PKG 0.481
Identifier Residue Sequence Organism Cell Line
SIGNOR-270291 Homo sapiens HeLa Cell, HEP-3B Cell
pmid sentence
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine). Sequences from the ALDA, PFKL, and PGK1 genes containing HIF-1 binding sites mediated hypoxia-inducible transcription in transient expression assays.
Publications: 1 Organism: Homo Sapiens
+ PKGup-regulates quantity img/direct-activation.png chemical modification 3-phosphonato-D-glycerate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266507 Homo sapiens
pmid sentence
Phosphoglycerate kinase generates one molecule of ATP by catalyzing the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. Two isozymes of PGK exist: PGK-1, ubiquitously expressed in all somatic cells, and PGK-2, expressed only in spermatozoa.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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