Relation Results

Summary

Name Hexokinase
Primary ID SIGNOR-PF76
Type protein family
Formed by GCK, HK1, HK2, HK3
Relations 20
Pathways Glycogenesis, Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.2940.70.80.3610.4960.4220.70.80.4630.4960.5940.2670.70.20.80.2USF1HexokinaseChaperone-mediated autophagyglucoseHIF-1 complexAKTTP53Cell_deathα-D-glucoseMYCAKT1PDX1FLT3GlycolysisTRAF6alpha-D-glucose 6-phosphate(2-)BACH1

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Relations
Regulator
Mechanism
target
score ℹ
+ USF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Hexokinase 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-270263 Homo sapiens Hep-G2 Cell
pmid sentence
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element
Identifier Residue Sequence Organism Cell Line
SIGNOR-267797 Homo sapiens Hep-G2 Cell
pmid sentence
Cotransfection of an expression plasmid encoding USF1 into HepG2 hepatoma cells resulted in the activation of the glucokinase promoter, dependent on the integrity of the P2 element
Publications: 2 Organism: Homo Sapiens
+ Chaperone-mediated autophagydown-regulates quantity by destabilization img/direct_inhibition.png Hexokinase 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270269 Homo sapiens ES-2 Cell
pmid sentence
Our proteome analysis revealed that HK2 is a CMA substrate and that its degradation by CMA is regulated by glucose availability.
Publications: 1 Organism: Homo Sapiens
+ glucoseup-regulates quantity by stabilization img/direct-activation.png Hexokinase 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270265 Homo sapiens ES-2 Cell
pmid sentence
Consistently, treatment of cells with 2-deoxy-d-glucose (2DG), which completely inhibits glucose metabolism, leads to HK2 degradation and cell death in combination with C43
Publications: 1 Organism: Homo Sapiens
+ HIF-1 complexup-regulates quantity img/direct-activation.png transcriptional regulation Hexokinase 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-267494 Homo sapiens Burkitt Lymphoma Cell Line
pmid sentence
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ AKTup-regulates activity img/direct-activation.png phosphorylation Hexokinase 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-267577 Homo sapiens Cardiomyocyte Cell Line
pmid sentence
Earlier studies found that expression of active Akt increases mitochondrial HK activity and the anti-apoptotic effect of Akt required mitoHK
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ TP53down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation Hexokinase 0.422
Identifier Residue Sequence Organism Cell Line
SIGNOR-270272 Homo sapiens
pmid sentence
P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In addition, p53 directly binds and inhibits G6PD activity and downregulates the pentose phosphate pathway.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ Hexokinasedown-regulates activity img/indirect_inhibition.png Cell_death 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270309 Mus musculus Fibroblast
pmid sentence
HK II via its mitochondrial location also suppresses the death of cancer cells, thus increasing their possibility for metastasis and the ultimate death of the human host
Publications: 1 Organism: Mus Musculus
+ Hexokinasedown-regulates quantity img/direct_inhibition.png chemical modification α-D-glucose 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266459 Homo sapiens
pmid sentence
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenesis, Glycolysis and Gluconeogenesis
+ HIF-1 complexup-regulates quantity by expression img/direct-activation.png transcriptional regulation Hexokinase 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-267500 Homo sapiens
pmid sentence
HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ MYCup-regulates quantity img/direct-activation.png transcriptional regulation Hexokinase 0.463
Identifier Residue Sequence Organism Cell Line
SIGNOR-270270 Homo sapiens
pmid sentence
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration.
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates activity img/direct-activation.png phosphorylation Hexokinase 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-270267 Homo sapiens Nasopharyngeal Carcinoma Cell
pmid sentence
K63-linked ubiquitination enhances the interaction between Akt and HK2 and eventually increases HK2 phosphorylation on Thr473 and mitochondrial localization
Publications: 1 Organism: Homo Sapiens
+ PDX1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Hexokinase 0.594
Identifier Residue Sequence Organism Cell Line
SIGNOR-267798 Homo sapiens HIT-T15 Cell
pmid sentence
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promoter. The results of reporter gene analyses using HIT-T15 cells revealed that the gene promoter was comprised of multiple cis-acting elements, including two primarily important cis-motifs: a palindrome structure, hPal-1, and the insulin gene cis-motif A element-like hUPE3. While both elements were bound specifically by nuclear proteins, it was the homeodomain-containing transcription factor insulin promoter factor 1 (IPF1)/STF-1/PDX-1 that bound to the hUPE3 site: IPF1, when expressed in CHO-K1 cells, became bound to the hUPE3 site and activated transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270264 Homo sapiens HIT-T15 Cell
pmid sentence
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis of glucokinase (GK) gene regulation, we assessed the structure and regulation of the human GK gene beta-cell-type promoter. The results of reporter gene analyses using HIT-T15 cells revealed that the gene promoter was comprised of multiple cis-acting elements, including two primarily important cis-motifs: a palindrome structure, hPal-1, and the insulin gene cis-motif A element-like hUPE3. While both elements were bound specifically by nuclear proteins, it was the homeodomain-containing transcription factor insulin promoter factor 1 (IPF1)/STF-1/PDX-1 that bound to the hUPE3 site: IPF1, when expressed in CHO-K1 cells, became bound to the hUPE3 site and activated transcription.
Publications: 2 Organism: Homo Sapiens
+ FLT3up-regulates activity img/indirect-activation.png Hexokinase 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-270268 Homo sapiens Acute Lymphoblastic Leukemia Cell Line
pmid sentence
FLT3/ITD causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on glycolysis and sensitive to pharmacological inhibition of glycolytic activity
Publications: 1 Organism: Homo Sapiens
+ Hexokinaseup-regulates activity img/indirect-activation.png Glycolysis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270310 Homo sapiens
pmid sentence
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase.
Publications: 1 Organism: Homo Sapiens
+ TRAF6down-regulates quantity img/direct_inhibition.png ubiquitination Hexokinase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270271 Homo sapiens HEK-293 Cell
pmid sentence
The Lys63-linked ubiquitination of HK2 catalyzed by the E3 ligase TRAF6 was critical for the subsequent recognition of HK2 by the autophagy receptor protein SQSTM1/p62 for the process of selective autophagic degradation.
Publications: 1 Organism: Homo Sapiens
+ Hexokinaseup-regulates quantity img/direct-activation.png chemical modification alpha-D-glucose 6-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266449 Homo sapiens
pmid sentence
Hexokinase catalyzes the phosphorylation of glucose to G6P, using ATP as a phosphoryl donor.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenesis, Glycolysis and Gluconeogenesis
+ BACH1up-regulates quantity img/direct-activation.png transcriptional regulation Hexokinase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270266 Homo sapiens
pmid sentence
BACH1 activates transcription of Hexokinase 2 and Gapdh and increases glucose uptake, glycolysis rates, and lactate secretion, thereby stimulating glycolysis-dependent metastasis of mouse and human lung cancer cells.
Publications: 1 Organism: Homo Sapiens
+ Hexokinaseup-regulates img/indirect-activation.png Glycolysis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267782 Homo sapiens
pmid sentence
The first step in metabolism of glucose (Glc) is usually phosphorylation, catalyzed by hexokinase.
Publications: 1 Organism: Homo Sapiens
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