Relation Results

Summary

Name Aldolase
Primary ID SIGNOR-PF75
Type protein family
Formed by ALDOA, ALDOB, ALDOC
Relations 10
Pathways Glycolysis and Gluconeogenesis

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Type: Score: Layout: SPV 
0.20.2570.5020.3420.3160.20.80.20.80.8NCOA1AldolasePPARGC1AZNF224HIF1AHNF1ADBPD-glyceraldehyde 3-phosphate(2-)TRIM28glycerone phosphate(2-)beta-D-fructofuranose 1,6-bisphosphate(4-)

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Relations
Regulator
Mechanism
target
score ℹ
+ NCOA1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270223 Homo sapiens Hep-G2 Cell
pmid sentence
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate.
Publications: 1 Organism: Homo Sapiens
+ PPARGC1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.257
Identifier Residue Sequence Organism Cell Line
SIGNOR-270226 Homo sapiens Hep-G2 Cell
pmid sentence
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate.
Publications: 1 Organism: Homo Sapiens
+ ZNF224down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Aldolase 0.502
Identifier Residue Sequence Organism Cell Line
SIGNOR-270227 Homo sapiens
pmid sentence
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor.
Publications: 1 Organism: Homo Sapiens
+ HIF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.342
Identifier Residue Sequence Organism Cell Line
SIGNOR-270229 Homo sapiens
pmid sentence
we characterize hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes. Our data establish that functional hypoxia-response elements consist of a pair of contiguous transcription factor binding sites at least one of which contains the core sequence 5'-RCGTG-3' and is recognized by HIF-1. These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1.
Publications: 1 Organism: Homo Sapiens
+ HNF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.316
Identifier Residue Sequence Organism Cell Line
SIGNOR-270224 Homo sapiens Hep-G2 Cell
pmid sentence
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators
Publications: 1 Organism: Homo Sapiens
+ DBPup-regulates quantity by expression img/indirect-activation.png transcriptional regulation Aldolase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270225 Homo sapiens Hep-G2 Cell
pmid sentence
Contransfection experiments of aldolase B/CAT constructs and of expression vectors for different transcription factors were carried out in human hepatoma Hep G2 cells. We found that DBP and HNF-1 are strong transactivators of the aldolase B promoter while C/EBP and vHNF-1 are only weak activators
Publications: 1 Organism: Homo Sapiens
+ Aldolaseup-regulates quantity img/direct-activation.png chemical modification D-glyceraldehyde 3-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266482 Homo sapiens
pmid sentence
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ TRIM28down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Aldolase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270228 Homo sapiens
pmid sentence
We previously reported that ZNF224, a novel Krüppel-associated box-containing zinc-finger protein, represses aldolase A gene transcription by interacting with the KAP-1 co-repressor.
Publications: 1 Organism: Homo Sapiens
+ Aldolaseup-regulates quantity img/direct-activation.png chemical modification glycerone phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266486 Homo sapiens
pmid sentence
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ Aldolasedown-regulates quantity img/direct_inhibition.png chemical modification beta-D-fructofuranose 1,6-bisphosphate(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266490 Homo sapiens
pmid sentence
Aldolase catalyzes the reversible conversion of FBP to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP; Figure 1). Aldolase is a tetramer of identical subunits of 40 kDa each, and 3 distinct isoenzymes have been identified: aldolase A, B, and C.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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