Relation Results

Summary

Name α-Catenin
Primary ID SIGNOR-PF72
Type protein family
Formed by CTNNA1, CTNNA2, CTNNA3
Relations 13

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Type: Score: Layout: SPV 
0.4110.70.6730.20.3990.2520.20.9240.20.20.4980.472PTPN11α-CateninF-actin_assemblyCDH1YAP1CSNK2A1GATA4CTNNB1JUPCDH11MEF2C

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Relations
Regulator
Mechanism
target
score ℹ
+ PTPN11down-regulates activity img/direct_inhibition.png dephosphorylation α-Catenin 0.411
Identifier Residue Sequence Organism Cell Line
SIGNOR-265824 Homo sapiens
pmid sentence
Tyr148 of beta-catenin is an shp2 target dephosphorylation site. Together, these results suggest that beta-catenin plays a suppressor role in cell transformation and that shp2, by dephosphorylating beta-catenin, promotes mitogenic, cell survival and transformation signals.
Publications: 1 Organism: Homo Sapiens
+ α-Cateninup-regulates img/direct-activation.png F-actin_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265814 Homo sapiens
pmid sentence
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin
Publications: 1 Organism: Homo Sapiens
+ CDH1up-regulates activity img/direct-activation.png binding α-Catenin 0.673
Identifier Residue Sequence Organism Cell Line
SIGNOR-265821 Homo sapiens
pmid sentence
Additionally, the E-cadherin associated protein _-catenin regulates YAP directly by sequestering YAP/14-3-3 complexes in the cytoplasm.
Publications: 1 Organism: Homo Sapiens
+ α-Catenindown-regulates activity img/direct_inhibition.png binding YAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265820 Homo sapiens
pmid sentence
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-265823 Homo sapiens
pmid sentence
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation.
Publications: 2 Organism: Homo Sapiens
+ CSNK2A1down-regulates activity img/direct_inhibition.png phosphorylation α-Catenin 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-265822 Homo sapiens Glioblastoma Cell
pmid sentence
We demonstrate here that egfr activation results in disruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via ck2alpha-dependent phosphorylation of alpha-catenin at s641.
Publications: 1 Organism: Homo Sapiens
+ GATA4up-regulates quantity by expression img/direct-activation.png transcriptional regulation α-Catenin 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-265815 Homo sapiens Cardiac Muscle Fiber
pmid sentence
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter
Publications: 1 Organism: Homo Sapiens
+ α-Cateninup-regulates quantity img/direct-activation.png relocalization CTNNB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265818 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ CTNNB1up-regulates activity img/direct-activation.png binding α-Catenin 0.924
Identifier Residue Sequence Organism Cell Line
SIGNOR-265813 Homo sapiens
pmid sentence
At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin
Publications: 1 Organism: Homo Sapiens
+ α-Cateninup-regulates quantity img/direct-activation.png relocalization JUP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265819 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ α-Cateninup-regulates quantity img/direct-activation.png relocalization CDH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265817 Homo sapiens Colonic Cancer Cell
pmid sentence
Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14
Publications: 1 Organism: Homo Sapiens
+ CDH11up-regulates activity img/direct-activation.png binding α-Catenin 0.498
Identifier Residue Sequence Organism Cell Line
SIGNOR-265825 Homo sapiens
pmid sentence
Cadherin-11 is localized to a detergent-soluble pool and is associated with both alpha- and beta-catenin
Publications: 1 Organism: Homo Sapiens
+ MEF2Cup-regulates quantity by expression img/direct-activation.png transcriptional regulation α-Catenin 0.472
Identifier Residue Sequence Organism Cell Line
SIGNOR-265816 Homo sapiens Cardiac Muscle Fiber
pmid sentence
GATA-4 and MEF2C are known to bind to the GATA box 2 in the major promoter of CTNNA3 and this element is essential in directly regulating expression of CTNNA3 in cardiac muscle cells. The co-transfection of GATA-4 with MEF2C leads to a synergistic activation of the CTNNA3 promoter
Publications: 1 Organism: Homo Sapiens
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