Relation Results

Summary

Name 14-3-3
Primary ID SIGNOR-PF7
Type protein family
Formed by SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ
Relations 26
Pathways Hippo Signaling, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.20.20.20.20.7040.20.3010.20.20.20.20.20.20.20.20.5150.20.20.20.20.20.214-3-3BADWWTR1FOXO3HDAC5FOXOAKT1S1DAB2IPYAP1NEFLMLXIPLTNK1KHSRPGRB10RASSF1EDC3mTORC1BCL2L11CABLES1GPSM3HJURPMAP3K5RGS18

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Relations
Regulator
Mechanism
target
score ℹ
+ 14-3-3down-regulates img/direct_inhibition.png binding BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-81106 Homo sapiens
pmid sentence
14-3-3 blocks bad activity by promoting ser-155 phosphorylation, which induces the dissociation of bad and bcl-xl. in the presence of survival factor il-3, cells phosphorylated bad on two serine residues embedded in 14-3-3 consensus binding sites. Only the nonphosphorylated bad heterodimerized with bcl-x(l) at membrane sites to promote cell death.
Identifier Residue Sequence Organism Cell Line
SIGNOR-44855 Homo sapiens
pmid sentence
14-3-3 blocks bad activity by promoting ser-155 phosphorylation, which induces the dissociation of bad and bcl-xl. in the presence of survival factor il-3, cells phosphorylated bad on two serine residues embedded in 14-3-3 consensus binding sites. Only the nonphosphorylated bad heterodimerized with bcl-x(l) at membrane sites to promote cell death.
Publications: 2 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding WWTR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-169716 Homo sapiens
pmid sentence
Phosphorylation of yap ser127 and of the corresponding sites in yki and taz generates a protein-binding motif for the 14-3-3 family proteins, which, upon binding by a 14-3-3 protein, leads to their cytoplasmic retention.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ 14-3-3down-regulates img/direct_inhibition.png binding FOXO3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-15849 Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Progressive increase in akt activation during prostate cancer progression led to increase phosphorylation of foxo3a and binding with 14-3-3, which potentially affected its transcriptional activity in age-specific manner.
Identifier Residue Sequence Organism Cell Line
SIGNOR-183608 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
In this study, we demonstrate that akt also regulates the activity of fkhrl1, a member of the forkhead family of transcription factors. In the presence of survival factors, akt phosphorylates fkhrl1, leading to fkhrl1's association with 14-3-3 proteins and fkhrl1's retention in the cytoplasm. Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Publications: 2 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding HDAC5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-89444 Homo sapiens
pmid sentence
In the cytoplasm, 14-3-3 proteins bind the phosphorylated hdac5 and retain it in the cytosol.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ 14-3-3down-regulates img/direct_inhibition.png binding FOXO 0.704
Identifier Residue Sequence Organism Cell Line
SIGNOR-252818 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
In this study, we demonstrate that akt also regulates the activity of fkhrl1, a member of the forkhead family of transcription factors. In the presence of survival factors, akt phosphorylates fkhrl1, leading to fkhrl1's association with 14-3-3 proteins and fkhrl1's retention in the cytoplasm. Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252819 Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Progressive increase in akt activation during prostate cancer progression led to increase phosphorylation of foxo3a and binding with 14-3-3, which potentially affected its transcriptional activity in age-specific manner.
Publications: 2 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding AKT1S1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-162003 Homo sapiens
pmid sentence
Akt can phosphorylate pras40, a raptor binding protein that also acts as an inhibitor of torc1. Akt-mediated phosphorylation of pras40 again promotes 14-3-3 binding, in this case leading to relief from pras40-mediated inhibition.
Publications: 1 Organism: Homo Sapiens
+ DAB2IPdown-regulates activity img/direct_inhibition.png binding 14-3-3 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-254773 Homo sapiens
pmid sentence
DAB2IP then displaces the inhibitory binding between ASK1 and 14-3-3 protein, favoring ASK1 activation
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding YAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-169719 Homo sapiens
pmid sentence
Phosphorylation of yap ser127 and of the corresponding sites in yki and taz generates a protein-binding motif for the 14-3-3 family proteins, which, upon binding by a 14-3-3 protein, leads to their cytoplasmic retention. One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73.
Identifier Residue Sequence Organism Cell Line
SIGNOR-97481 Chlorocebus aethiops COS Cell
pmid sentence
One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73.
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:Hippo Signaling
+ 14-3-3down-regulates activity img/direct_inhibition.png binding NEFL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269953 Homo sapiens
pmid sentence
These results suggest the important role of 14-3-3 in the dynamic regulation of NF-L assembly, and in the capacity to prevent the formation of NF-L aggregates. all seven isoforms specifically interacted with NF-L, but not NF-M or NF-H. specific interaction of 14-3-3 proteins with phosphorylated NF-L subunits also indicated the role of 14-3-3 and NF-L phosphorylation in the disassembly of neurofilaments. What is more, binding of 14-3-3 to phosphorylated NF-L subunits may prevent the dephosphorylation of these subunits by phosphatases, maintaining the hyperphosphorylation state of the subunits, which facilitates the disassembly of neurofilaments.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates activity img/direct_inhibition.png relocalization MLXIPL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255667 Rattus norvegicus
pmid sentence
AMP inhibits the nuclear localization of ChREBP through an allosteric activation of ChREBP/14-3-3 interactions
Publications: 1 Organism: Rattus Norvegicus
+ 14-3-3down-regulates activity img/direct_inhibition.png binding TNK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273869 Homo sapiens A-549 Cell
pmid sentence
We also discover a MARK-mediated phosphorylation on TNK1 at S502 that promotes an interaction between TNK1 and 14-3-3, which sequesters TNK1 and inhibits its kinase activity.Phosphorylation of TNK1 at S502 within the proline rich domain is required for TNK1 binding to 14-3-3.MARKs mediate phosphorylation at S502 and 14-3-3 binding to TNK1, which restrains the movement of TNK1 into heavy membrane-associated clusters.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding KHSRP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-151212 Homo sapiens
pmid sentence
Akt phosphorylates ksrp at a unique serine residue, creating a functional binding site for the molecular chaperone 14-3-3. As a consequence, akt activation impairs ksrp ability to interact with the exoribonucleolytic complex exosome and, in turn, to promote rapid mrna decay.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3up-regulates img/direct-activation.png binding GRB10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-134198 Homo sapiens
pmid sentence
The interaction of phosphorylated grb10 with 14-3-3 may lead to the translocation of grb10 back to the cytosol
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding RASSF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-175121 Homo sapiens
pmid sentence
Basal inactivation of rassf1a is achieved by rassf1a self association and via 14-3-3 interactions (to isoforms s and e) at serine 175/178/179 of rassf1a.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ 14-3-3down-regulates activity img/direct_inhibition.png binding EDC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262630 Cricetulus griseus CHO Cell
pmid sentence
14-3-3 binding to EDC3 resulted in a significant decrease in the binding of several key mRNA regulatory factors such as PABP and Y-box-binding protein 1 to EDC3.
Publications: 1 Organism: Cricetulus Griseus
+ 14-3-3down-regulates img/direct_inhibition.png binding mTORC1 0.515
Identifier Residue Sequence Organism Cell Line
SIGNOR-217565 Homo sapiens
pmid sentence
Akt can phosphorylate pras40, a raptor binding protein that also acts as an inhibitor of torc1. Akt-mediated phosphorylation of pras40 again promotes 14-3-3 binding, in this case leading to relief from pras40-mediated inhibition.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding BCL2L11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-141577 Homo sapiens
pmid sentence
Cytokine stimulation promotes bim(el) binding to 14-3-3 proteins. Akt could directly phosphorylate a gst-bim(el) fusion protein and identified the akt phosphorylation site in the bim(el) domain as ser(87). we propose that ser87 of bimel is an important regulatory site that is targeted byakt to attenuate thepro-apoptotic function of bim el, thereby promoting cell survival.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates activity img/direct_inhibition.png binding CABLES1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276758 in vitro
pmid sentence
Here, we report that Cables1 levels are controlled by a phosphorylation and 14-3-3-dependent mechanism. Mutagenic analyses identified two residues, T44 and T150, that are specifically critical for 14-3-3 binding and that serve as substrates for phosphorylation by the cell survival kinase Akt, which by binding directly to Cables1 recruits 14-3-3 to the complex.Ectopic expression of activated Akt (AKT1) prevented Cables1-induced apoptosis.
Publications: 1 Organism: In Vitro
+ 14-3-3up-regulates quantity by stabilization img/direct-activation.png binding GPSM3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264866 Homo sapiens Monocyte
pmid sentence
Mutation of serine 35 completely abrogates the 14-3-3 interaction (e.g. Fig. 2, B–F), suggesting that phosphorylation of serine 35 is obligatory for 14-3-3 binding|The GPSM3/14-3-3 interaction is seen to stabilize GPSM3 from degradation and also support the nuclear exclusion of both proteins.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3up-regulates activity img/direct-activation.png binding HJURP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262624 in vitro
pmid sentence
These data define a new protein complex in mammalian cells where 14‐3‐3 associates with FAKTS through phosphorylated S479. Our research identifies a widely expressed eukaryotic protein FAKTS, as a new Akt/PKB substrate localized in the nucleus. Akt/PKB promotes FAKTS association with 14‐3‐3, placing FAKTS under the control of 14‐3‐3 proteins. FAKTS may play an important role in transmitting Akt/PKB‐mediated signals in the complex network of intracellular signal transduction.
Publications: 1 Organism: In Vitro
+ 14-3-3down-regulates img/direct_inhibition.png binding MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-69408 Homo sapiens HeLa Cell
pmid sentence
14-3-3 may suppress ask1-induced cell death by directly inhibiting the catalytic activity of ask1.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates activity img/direct_inhibition.png binding RGS18 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273787 Homo sapiens Blood Platelet
pmid sentence
Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. 
Publications: 1 Organism: Homo Sapiens
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