Relation Results

Summary

Name Histone H2B
Primary ID SIGNOR-PF68
Type protein family
Formed by H2BC1, H2BC11, H2BC12, H2BC13, H2BC14, H2BC15, H2BC17, H2BC18, H2BC20P, H2BC21, H2BC3, H2BC4, H2BC5, H2BC9, H2BE1, H2BS1, H2BU1, H2BW1, H2BW2
Relations 6

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Type: Score: Layout: SPV 
0.20.20.20.20.20.2BAF250b E3 ligaseHistone H2BRNF168MSL acetyltransferaseNucleosomeARID1BSLBP

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Relations
Regulator
Mechanism
target
score ℹ
+ BAF250b E3 ligasedown-regulates activity img/direct_inhibition.png ubiquitination Histone H2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271441 Homo sapiens HeLa Cell
pmid sentence
In the present work, we show that BAF250 associates with elongin C (Elo C), cullin 2 (Cul2), and Roc1 to form an E3 ubiquitin ligase. BAF250 forms an E3 ubiquitin ligase with Elo B/C, Cul2, and Roc1 that targets histone H2B. H2B-Ub has been shown to be required for transcriptional activation in vitro
Publications: 1 Organism: Homo Sapiens
+ Histone H2Bup-regulates img/direct-activation.png binding RNF168 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265372 Homo sapiens
pmid sentence
Rnf168 is recruited to sites of dna damage by binding to ubiquitylated histone h2a.
Publications: 1 Organism: Homo Sapiens
+ MSL acetyltransferasedown-regulates activity img/direct_inhibition.png monoubiquitination Histone H2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271978 Homo sapiens HeLa Cell
pmid sentence
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation.
Publications: 1 Organism: Homo Sapiens
+ Histone H2Bform complex img/form-complex.png binding Nucleosome 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265310 in vitro
pmid sentence
The elemental repeating unit of chromatin is the nucleosome core particle (NCP), which consists of 146 base pairs of DNA wrapped in 1.65 left-handed superhelical turns around the histone octamer. The histone octamer comprises two each of the core histones, H2A, H2B, H3 and H4, which form two H2A/H2B dimers and an H3/H4 tetramer, respectively, in the NCP.
Publications: 1 Organism: In Vitro
+ ARID1Bdown-regulates activity img/direct_inhibition.png ubiquitination Histone H2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271442 in vitro
pmid sentence
The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro. 
Publications: 1 Organism: In Vitro
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation Histone H2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265375 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
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