Relation Results

Summary

Name Cytoplasmic_Dynein
Primary ID SIGNOR-PF67
Type protein family
Formed by DYNC1H1, DYNC1I1, DYNC1I2, DYNC1LI1, DYNC2H1, DYNLL1, DYNLL2, DYNLRB1, DYNLRB2
Relations 5

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Type: Score: Layout: SPV 
0.70.70.70.20.7Cytoplasmic_DyneinOrganelle_transportSpindle_assemblyMicrotubule-based_movementDCTN2Cilium_assembly

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Relations
Regulator
Mechanism
target
score ℹ
+ Cytoplasmic_Dyneinup-regulates img/indirect-activation.png Organelle_transport 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265058
pmid sentence
The most abundant cytoplasmic dynein complex, cytoplasmic dynein 1, is involved in functions as diverse as spindle-pole organization and nuclear migration during mitosis, the positioning and functioning of the endoplasmic reticulum, the Golgi apparatus, and the nucleus, and also the minus-end-directed transport of vesicles, including endosomes and lysosomes, along microtubules and retrograde axonal transport in neurons.
Publications: 1
+ Cytoplasmic_Dyneinup-regulates img/indirect-activation.png Spindle_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265059
pmid sentence
The most abundant cytoplasmic dynein complex, cytoplasmic dynein 1, is involved in functions as diverse as spindle-pole organization and nuclear migration during mitosis, the positioning and functioning of the endoplasmic reticulum, the Golgi apparatus, and the nucleus, and also the minus-end-directed transport of vesicles, including endosomes and lysosomes, along microtubules and retrograde axonal transport in neurons.
Publications: 1
+ Cytoplasmic_Dyneinup-regulates img/indirect-activation.png Microtubule-based_movement 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265019
pmid sentence
Dyneins are large multi-subunit protein complexes that undertake a wide range of roles within the cell. They are adenosine triphosphate (ATP)–driven, microtubule minus-end-directed molecular motors that can be divided, based on function, into two classes: axonemal and cytoplasmic dyneins
Publications: 1
+ DCTN2up-regulates activity img/direct-activation.png relocalization Cytoplasmic_Dynein 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265018
pmid sentence
ZW10 interacts with dynamitin, a subunit of the dynein-dynactin complex (Echeverri et al., 1996), thereby recruiting this motor to kinetochores
Publications: 1
+ Cytoplasmic_Dyneinup-regulates img/indirect-activation.png Cilium_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265022
pmid sentence
A second cytoplasmic dynein complex, cytoplasmic dynein 2, has a role in intraflagellar transport (IFT), a process required for ciliary/flagellar assembly
Publications: 1
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