Relation Results

Summary

Name Axonemal_Dynein
Primary ID SIGNOR-PF66
Type protein family
Formed by AXDND1, CFAP94, DNAH1, DNAH10, DNAH11, DNAH12, DNAH14, DNAH17, DNAH2, DNAH3, DNAH5, DNAH6, DNAH7, DNAH8, DNAH9, DNAI1, DNAI2, DNAI3, DNAI4, DNAL1, DNAL4
Relations 5

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Type: Score: Layout: SPV 
0.70.20.20.20.7Axonemal_DyneinMicrotubule-based_movementCFAP53FOXJ1ODAD4Cilium_movement

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Relations
Regulator
Mechanism
target
score ℹ
+ Axonemal_Dyneinup-regulates img/indirect-activation.png Microtubule-based_movement 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265020
pmid sentence
Dyneins are large multi-subunit protein complexes that undertake a wide range of roles within the cell. They are adenosine triphosphate (ATP)–driven, microtubule minus-end-directed molecular motors that can be divided, based on function, into two classes: axonemal and cytoplasmic dyneins
Publications: 1
+ CFAP53up-regulates activity img/direct-activation.png binding Axonemal_Dynein 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265547 Mus musculus
pmid sentence
CFAP53 associates with axonemal microtubules of tracheal cilia and interacts with dynein proteins and the docking complex (DC)
Publications: 1 Organism: Mus Musculus
Tissue: Embryo
+ FOXJ1up-regulates quantity by expression img/direct-activation.png transcriptional regulation Axonemal_Dynein 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266939 Homo sapiens Basal Cell
pmid sentence
FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sperm associated antigen 6 (SPAG6); tektin 1 (TEKT1), TEKT2 and tubulin, alpha 1a (TUBA1A; Figure 3C and Additional file 2: Table S1).
Publications: 1 Organism: Homo Sapiens
+ ODAD4up-regulates activity img/direct-activation.png binding Axonemal_Dynein 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265546 Mus musculus
pmid sentence
CFAP53 likely facilitates the transport of TTC25 and the dyneins into cilia. CFAP53 at the centriolar satellites may form a complex with TTC25 and ODAs, including DNAH5 and DNAH11, and regulate their trafficking into the cilium (Fig 10B). It also interacts with ODA proteins including dynein heavy chains such as DNAH11 and possibly DNAH5/9. CFAP53 likely facilitates the transport of TTC25 and the dyneins into cilia.
Publications: 1 Organism: Mus Musculus
Tissue: Embryo
+ Axonemal_Dyneinup-regulates img/indirect-activation.png Cilium_movement 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265021
pmid sentence
Axonemal dyneins are responsible for the movement of cilia and flagella.
Publications: 1
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