Relation Results

Summary

Name GlyR
Primary ID SIGNOR-PF62
Type protein family
Formed by GLRA1, GLRA2, GLRA3, GLRB
Relations 10
Pathways GABAergic synapse

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Type: Score: Layout: SPV 
0.80.2730.80.80.80.8ethanolGlyRSRCtaurinebeta-alanineglycinechloride

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Relations
Regulator
Mechanism
target
score ℹ
+ ethanolup-regulates activity img/direct-activation.png chemical activation GlyR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267794 Xenopus laevis Oocyte
pmid sentence
Pharmacologically relevant concentrations of ethanol (10-200 mM) reversibly potentiated the glycine receptor function in all receptors. Ethanol potentiation depended on the glycine concentration used, with decreased potentiation observed at higher glycine concentrations.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270260 Xenopus laevis Oocyte
pmid sentence
Pharmacologically relevant concentrations of ethanol (10-200 mM) reversibly potentiated the glycine receptor function in all receptors. Ethanol potentiation depended on the glycine concentration used, with decreased potentiation observed at higher glycine concentrations.
Publications: 2 Organism: Xenopus Laevis
+ SRCup-regulates img/direct-activation.png phosphorylation GlyR 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-270262 Homo sapiens Neuron
pmid sentence
These findings indicate that glyr function is upregulated by ptks and this modulation is dependent on the tyrosine-413 residue of the beta subunit.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ taurineup-regulates activity img/direct-activation.png chemical activation GlyR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270259 Homo sapiens HEK-293 Cell
pmid sentence
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267793 Homo sapiens HEK-293 Cell
pmid sentence
For each mutant GlyR we examined the agonist efficacies of taurine and beta-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where beta-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human alpha-1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and beta-alanine act as full agonists of huma nalpha-1 GlyRs when expressed in this system.
Publications: 2 Organism: Homo Sapiens
+ beta-alanineup-regulates activity img/direct-activation.png chemical activation GlyR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270261 Homo sapiens HEK-293 Cell
pmid sentence
For each mutant GlyR we examined the agonist efficacies of taurine and β-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where β-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human α1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and β-alanine act as full agonists of human α1 GlyRs when expressed in this system.
Identifier Residue Sequence Organism Cell Line
SIGNOR-267795 Homo sapiens HEK-293 Cell
pmid sentence
For each mutant GlyR we examined the agonist efficacies of taurine and beta-alanine relative to glycine, the concentration of each agonist required for half-maximal current activation (EC50) and, in mutant GlyRs where beta-alanine and taurine exhibited partial or no agonist efficacy, the concentration required for half-maximal inhibition of glycine-gated currents (IC50).experiments described in this report were performed on human alpha-1 homomeric GlyRs recombinantly expressed in mammalian HEK 293 cells. Taurine and beta-alanine act as full agonists of huma nalpha-1 GlyRs when expressed in this system.
Publications: 2 Organism: Homo Sapiens
+ glycineup-regulates activity img/direct-activation.png chemical activation GlyR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264985 Homo sapiens
pmid sentence
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ SRCup-regulates activity img/direct-activation.png phosphorylation GlyR 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-267796 Homo sapiens Neuron
pmid sentence
These findings indicate that glyr function is upregulated by ptks and this modulation is dependent on the tyrosine-413 residue of the beta subunit.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ GlyRup-regulates quantity img/direct-activation.png relocalization chloride 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264984 Homo sapiens
pmid sentence
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem and retina.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
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