Relation Results

Summary

Name GABA-A
Primary ID SIGNOR-PF61
Type protein family
Formed by GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2
Relations 12
Pathways GABAergic synapse , Oxytocin signaling

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Type: Score: Layout: SPV 
0.70.20.80.20.20.20.20.80.20.20.20.2GABA-AExcitatory_synaptic_transmissionOxytocinchlorideCRHR2PCDH19CRHR1GABARAPgamma-aminobutyric acidGPHNPKADGCAP-2 complex

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Relations
Regulator
Mechanism
target
score ℹ
+ GABA-Adown-regulates img/indirect_inhibition.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264970 Homo sapiens
pmid sentence
Gamma-Aminobutyric acid (GABA1), the major inhibitory neurotransmitter in the brain, exerts its action via ionotropic GABAA and metabotropic GABAB receptors. GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS).
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
Pathways:GABAergic synapse , Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268578 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ GABA-Aup-regulates quantity img/direct-activation.png relocalization chloride 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264988 Homo sapiens
pmid sentence
GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS). |Mammalian GABAA-Rs are all anion-selective channels. Increased chloride permeability generally reduces neuronal excitability (inhibition)
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ GABA-Adown-regulates img/indirect_inhibition.png CRHR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268599 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ PCDH19up-regulates quantity by stabilization img/direct-activation.png binding GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267216 Rattus norvegicus Pyramidal Neuron
pmid sentence
Here, we found that PCDH19 binds the alpha subunits of GABAAR and regulates its surface availability and currents in cultured hippocampal neurons. The PCDH19 gene (Xp22.1) encodes the cell-adhesion protein protocadherin-19 (PCDH19) and is responsible for a neurodevelopmental pathology characterized by female-limited epilepsy, cognitive impairment and autistic features, the pathogenic mechanisms of which remain to be elucidated. Here, we identified a new interaction between PCDH19 and GABAA receptor (GABAAR) alpha subunits in the rat brain. PCDH19 shRNA-mediated downregulation reduces GABAAR surface expression and affects the frequency and kinetics of miniature inhibitory postsynaptic currents (mIPSCs) in cultured hippocampal neurons. 
Publications: 1 Organism: Rattus Norvegicus
+ GABA-Adown-regulates img/indirect_inhibition.png CRHR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268610 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ GABARAPup-regulates activity img/direct-activation.png binding GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264972 Homo sapiens Neuron
pmid sentence
GABARAP was originally isolated as a binding partner of the GABAA receptor γ2-subunit in a yeast two-hybrid screen, and was suggested to have a role in the targeting and clustering of GABAA receptors.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ gamma-aminobutyric acidup-regulates activity img/direct-activation.png chemical activation GABA-A 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264963 Homo sapiens
pmid sentence
Gamma-Aminobutyric acid (GABA1), the major inhibitory neurotransmitter in the brain, exerts its action via ionotropic GABAA and metabotropic GABAB receptors. GABAA receptors (GABAA-Rs) are the major inhibitory receptors in the central nervous system (CNS).
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
Pathways:GABAergic synapse
+ GPHNup-regulates quantity by stabilization img/direct-activation.png binding GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264964 Rattus norvegicus Neuron
pmid sentence
we demonstrate that GABA(A)Rs and gephyrin are intimately associated at inhibitory synapses in cultured rat neurons. Our results suggest that the direct binding of gephyrin to residues 360-375 of the α1 subunit and its modulation are likely to be important determinants for the stabilization of GABA(A)Rs at synaptic sites, thereby modulating the strength of synaptic inhibition.
Publications: 1 Organism: Rattus Norvegicus
Pathways:GABAergic synapse
+ PKAup-regulates quantity img/direct-activation.png phosphorylation GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264991 Homo sapiens Neuron
pmid sentence
The endocytosis of GABAARs is regulated by the interaction of the AP2 complex with β and γ2 subunits. Phosphorylation of β3 (S408/S409) and γ2 (Y365/Y367) by PKA/PKC and Src/Fyn, respectively, prevents binding to AP2 and thus stabilizes these receptors at the cell surface.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse , Oxytocin signaling
+ DGCup-regulates quantity img/direct-activation.png binding GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265442 Homo sapiens Neuron, Glial Cell
pmid sentence
 In brain, the DGC is involved in the organisation of GABA(A) receptors (GABA(A)Rs) and aquaporin-4 (AQP4)-containing protein complexes in neurons and glia, respectively. DGC-like complexes function in the postsynaptic clustering and stabilisation of GABAARs in a subset of inhibitory GABAergic synapses.
Publications: 1 Organism: Homo Sapiens
+ AP-2 complexdown-regulates quantity img/direct_inhibition.png relocalization GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264990 Homo sapiens Neuron
pmid sentence
The endocytosis of GABAARs is regulated by the interaction of the AP2 complex with β and γ2 subunits. Phosphorylation of β3 (S408/S409) and γ2 (Y365/Y367) by PKA/PKC and Src/Fyn, respectively, prevents binding to AP2 and thus stabilizes these receptors at the cell surface.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
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