Relation Results

Summary

Name HOMER
Primary ID SIGNOR-PF59
Type protein family
Formed by HOMER1, HOMER2, HOMER3
Relations 3
Pathways Glutamatergic synapse

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Type: Score: Layout: SPV 
0.20.4040.2HOMERSHANK3CAMK2ASHANK1

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Relations
Regulator
Mechanism
target
score ℹ
+ HOMERup-regulates activity img/direct-activation.png binding SHANK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264697 Homo sapiens Neuron
pmid sentence
It has been shown that Homer, a scaffold protein with a single EVH1 domain that binds to Shank, mGluR1, and other postsynaptic proteins (98) (Figure 3), exists as a tetramer, thus allowing it to cross-link several interacting proteins in the PSD
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ CAMK2Adown-regulates activity img/direct_inhibition.png phosphorylation HOMER 0.404
Identifier Residue Sequence Organism Cell Line
SIGNOR-264699 in vitro
pmid sentence
Homer3 is phosphorylated at Ser120, Ser159, and Ser176 by CaMKII in vitro. Homer3 phosphorylation reduces its affinity for target molecules and modulates the Ca2+ signaling patterns induced by mGluR1α activation
Publications: 1 Organism: In Vitro
Pathways:Glutamatergic synapse
+ HOMERup-regulates activity img/direct-activation.png binding SHANK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264698 Homo sapiens
pmid sentence
It has been shown that Homer, a scaffold protein with a single EVH1 domain that binds to Shank, mGluR1, and other postsynaptic proteins (98) (Figure 3), exists as a tetramer, thus allowing it to cross-link several interacting proteins in the PSD
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
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