Relation Results

Summary

Name KAR
Primary ID SIGNOR-PF57
Type protein family
Formed by GRIK1, GRIK2, GRIK3, GRIK4, GRIK5
Relations 3
Pathways Glutamatergic synapse

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Type: Score: Layout: SPV 
0.80.70.8KARcalcium(2+)Excitatory_synaptic_transmissionglutamic acid

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Relations
Regulator
Mechanism
target
score ℹ
+ KARup-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264940 Homo sapiens
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction. iGluRs and mGluRs can generate intracellular Ca2+ signals, albeit by different mechanisms, whose crosstalk has not been thoroughly explored (Figure 2C). iGluRs allow the influx of extracellular Ca2+ upon pore opening. This is widely acknowledged for NMDARs, which have a high Ca2+ conductance, but Ca2+ flux through AMPARs and KARs can still be substantial.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ KARup-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264693 Homo sapiens Neuron
pmid sentence
Glutamate receptor ion channels mediate excitatory responses at the majority of CNS synapses. The glutamate receptor ion channels (iGluRs) are abundantly expressed in the brain and spinal cord and mediate responses at the vast majority of excitatory synapses. Mammalian iGluRs are encoded by 18 genes that assemble to form four major families, the AMPA, kainate, NMDA and delta receptors. There are four AMPA receptor genes (GluR1–4); five kainate receptor genes (GluR5–7, plus KA1 and KA2); seven NMDA receptor genes (NR1, NR2A-D, NR3A and NR3B); and two delta subunits.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation KAR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264694 Homo sapiens
pmid sentence
Glutamate receptor ion channels mediate excitatory responses at the majority of CNS synapses. The glutamate receptor ion channels (iGluRs) are abundantly expressed in the brain and spinal cord and mediate responses at the vast majority of excitatory synapses. Mammalian iGluRs are encoded by 18 genes that assemble to form four major families, the AMPA, kainate, NMDA and delta receptors. There are four AMPA receptor genes (GluR1–4); five kainate receptor genes (GluR5–7, plus KA1 and KA2); seven NMDA receptor genes (NR1, NR2A-D, NR3A and NR3B); and two delta subunits.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
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