Relation Results

Summary

Name NMDA
Primary ID SIGNOR-PF56
Type protein family
Formed by GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B
Relations 9
Pathways Dopaminergic Synapse, Glutamatergic synapse

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Type: Score: Layout: SPV 
0.20.80.20.20.20.80.70.2NMDADLG4glutamic acidSHANK3DLG3PPP1CAcalcium(2+)Excitatory_synaptic_transmissionCTTN

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Relations
Regulator
Mechanism
target
score ℹ
+ NMDAup-regulates activity img/direct-activation.png binding DLG4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264801 Homo sapiens Neuron
pmid sentence
Another central component of the NMDA receptor signaling complex is the scaffold protein PSD-95 (also referred to as SAP-90). The first and second PDZ domains bind tightly to the tails of the NR2 subunits of the NMDA receptor
Identifier Residue Sequence Organism Cell Line
SIGNOR-264704 Homo sapiens Neuron
pmid sentence
Another central component of the NMDA receptor signaling complex is the scaffold protein PSD-95 (also referred to as SAP-90). The first and second PDZ domains bind tightly to the tails of the NR2 subunits of the NMDA receptor
Publications: 2 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation NMDA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264692 Homo sapiens
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse, Glutamatergic synapse
+ SHANK3up-regulates quantity img/direct-activation.png relocalization NMDA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264701 Homo sapiens Neuron
pmid sentence
SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK proteins then bind to the actin cytoskeleton and to Homer protein, which in turn interacts with mGluRs. Through these extended links, PSD95, SAPAP, SHANK and Homer proteins form a quaternary complex that brings together mGluR and NMDAR complexes in the PSD (FIG. 3).
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ DLG3up-regulates activity img/direct-activation.png relocalization NMDA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266005
pmid sentence
DLG3 plays a critical role in clustering of NMDA receptors at excitatory synapses.
Publications: 1
Tissue: Central Nervous System
+ PPP1CAdown-regulates activity img/direct_inhibition.png dephosphorylation NMDA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265061 Homo sapiens
pmid sentence
DARPP-32/PP1 cascade modulates the physiological properties of NMDA and AMPA receptors, and activation of the DARPP-32/PP1 signaling leads to parallel increase in the phosphorylation of NMDA receptor subunits and intracellular Ca2+ levels
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Dopaminergic Synapse
+ NMDAup-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264931 Homo sapiens
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction. iGluRs and mGluRs can generate intracellular Ca2+ signals, albeit by different mechanisms, whose crosstalk has not been thoroughly explored (Figure 2C). In contrast, group I mGluRs increase the intracellular Ca2+ concentration via a classical Gq-mediated mechanism that triggers release from intracellular stores through IP3 receptors
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse, Glutamatergic synapse
+ NMDAup-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264691 Homo sapiens Neuron
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse, Glutamatergic synapse
+ NMDAup-regulates quantity img/direct-activation.png relocalization CTTN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266598 Homo sapiens Brain
pmid sentence
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors.
Publications: 1 Organism: Homo Sapiens
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