Relation Results

Summary

Name MGluR
Primary ID SIGNOR-PF55
Type protein family
Formed by GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8
Relations 13
Pathways Glutamatergic synapse

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Type: Score: Layout: SPV 
0.2950.20.5670.80.80.4040.390.4040.4620.70.80.3830.8PRKCQMGluRGNASPRKCAADX-47273glutamic acidPRKCEPRKCZPRKCDPRKCGExcitatory_synaptic_transmission(1R,4S,5S,6S)-4-amino-2,2-dioxo-2$l^{6}-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acidPRKCBcalcium(2+)

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Relations
Regulator
Mechanism
target
score ℹ
+ PRKCQup-regulates activity img/direct-activation.png phosphorylation MGluR 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-270273 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ MGluRup-regulates activity img/direct-activation.png binding GNAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264689 Homo sapiens
pmid sentence
MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G proteins. The resulting change in conformation of the GPCR induced by ligand binding activates the G protein, which is composed of a heterotrimeric complex of α, β, and γ subunits.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
Pathways:Glutamatergic synapse
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation MGluR 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-270278 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ ADX-47273up-regulates img/direct-activation.png chemical activation MGluR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270276 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation MGluR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264688 Homo sapiens
pmid sentence
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ PRKCEup-regulates activity img/direct-activation.png phosphorylation MGluR 0.404
Identifier Residue Sequence Organism Cell Line
SIGNOR-270280 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ PRKCZup-regulates activity img/direct-activation.png phosphorylation MGluR 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-270274 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ PRKCDup-regulates activity img/direct-activation.png phosphorylation MGluR 0.404
Identifier Residue Sequence Organism Cell Line
SIGNOR-270275 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ PRKCGup-regulates activity img/direct-activation.png phosphorylation MGluR 0.462
Identifier Residue Sequence Organism Cell Line
SIGNOR-270279 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ MGluRup-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264690 Homo sapiens Neuron
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ (1R,4S,5S,6S)-4-amino-2,2-dioxo-2$l^{6}-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acidup-regulates img/direct-activation.png chemical activation MGluR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270281 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ PRKCBup-regulates activity img/direct-activation.png phosphorylation MGluR 0.383
Identifier Residue Sequence Organism Cell Line
SIGNOR-270277 in vitro
pmid sentence
Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839.
Publications: 1 Organism: In Vitro
+ MGluRup-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264930 Homo sapiens
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction. iGluRs and mGluRs can generate intracellular Ca2+ signals, albeit by different mechanisms, whose crosstalk has not been thoroughly explored (Figure 2C). iGluRs allow the influx of extracellular Ca2+ upon pore opening.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
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