Relation Results

Summary

Name PP1
Primary ID SIGNOR-PF54
Type protein family
Formed by PPP1CA, PPP1CB, PPP1CC
Relations 40
Pathways Glycogenolysis

Viewer

Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.20.20.20.20.20.5010.20.20.4820.20.5030.20.20.20.7660.8060.3960.3990.5510.450.7030.6710.5610.20.20.20.6630.20.20.3840.677PP1CADPYGLPYGMTP53CASP2CDK9AXIN1MDM2AKT1AHCYL1GSK3BCCND3NOS3MAPK1NEK2CDC25CCDK5SP3ERK1/2MAPK3SLC4A4SP1PPP1R9BPPP1R2PYGPPP1R1CPHACTR1AKTPPP1R3BPPP1R3CCDK1IKZF1CFTRAURKAPPP1R8GbetaCDK2PPP1R1B

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation CAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264653 Ser1406 GAGGRRLsSFVTKGY in vitro
pmid sentence
Cyclic AMP-dependent protein kinase phosphorylates two serine residues on the protein termed sites 1 and 2| Site 1: Arg-Leu-Ser(P)-Ser-Phe-Val-Thr-Lys Site 2: Ile-His-Arg-Ala-Ser(P)-Asp-Pro-Gly-Leu-Pro-Ala-Glu-Glu-Pro-Lys | Both phosphorylation and activation can be reversed using purified preparations of the catalytic subunits of protein phosphatases 1- and -2A, and inactivation also correlates better with dephosphorylation of site 1 rather than site 2.
Publications: 1 Organism: In Vitro
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation PYGL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267403 Ser15 QEKRRQIsIRGIVGV Homo sapiens
pmid sentence
GP is the first protein whose function was discovered to be regulated by reversible protein phosphorylation, which is controlled by phosphorylase kinase (PhK) and protein phosphatase 1 (PP1). Here we report that lysine acetylation negatively regulates GP activity by both inhibiting enzyme activity directly and promoting dephosphorylation
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation PYGM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267402 Ser15 QEKRKQIsVRGLAGV Homo sapiens Chang Cell
pmid sentence
GP is the first protein whose function was discovered to be regulated by reversible protein phosphorylation, which is controlled by phosphorylase kinase (PhK) and protein phosphatase 1 (PP1). Here we report that lysine acetylation negatively regulates GP activity by both inhibiting enzyme activity directly and promoting dephosphorylation
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264670 Ser15 PSVEPPLsQETFSDL Homo sapiens
pmid sentence
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway.
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates activity img/direct-activation.png dephosphorylation CASP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264661 Ser164 STDTVEHsLDNKDGP in vitro
pmid sentence
Nutrient-replete oocytes inhibit C2 via S135 phosphorylation catalyzed by calcium/calmodulin-dependent protein kinase II. We now show that C2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. Moreover, we determined that S135 dephosphorylation is catalyzed by protein phosphatase-1 (PP1), which directly binds C2.
Publications: 1 Organism: In Vitro
+ PP1up-regulates img/direct-activation.png dephosphorylation CDK9 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264671 Ser175 FGLARAFsLAKNSQP Homo sapiens
pmid sentence
Protein phosphatase-1 activates cdk9 by dephosphorylating ser175
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation AXIN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264660 Ser217 YTRTGSEsPKVCSDQ Homo sapiens
pmid sentence
The data suggest that PP1 controls Wnt signaling through interaction with, and regulated dephosphorylation of, axin| Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. Wnt-regulated changes in axin phosphorylation, mediated by PP1, may therefore determine beta-catenin transcriptional activity| Four sites, S80, S82, S222, and S473, were identified to be PP1 regulated
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MDM2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264666 Ser370 KKTIVNDsRESCVEE Homo sapiens U2-OS Cell
pmid sentence
Three phosphorylation sites identified are Ser342, Ser367, and Ser403. In the present study, we identify protein phosphatase 1 (PP1) as a negative regulator in the p53 signaling pathway. PP1 directly interacts with Mdmx and specifically dephosphorylates Mdmx at Ser367. The dephosphorylation of Mdmx increases its stability and thereby inhibits p53 activity.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264658 Ser473 RPHFPQFsYSASGTA Homo sapiens SK-BR-3 Cell
pmid sentence
Here, we identify PP1 as a serine/threonine phosphatase that associates with and dephosphorylates AKT in breast cancer cells|The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Publications: 1 Organism: Homo Sapiens
+ PP1 img/unknown.png dephosphorylation AHCYL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264657 Ser68 RSLSRSIsQSSTDSY Mus musculus
pmid sentence
Moreover, IRBIT-associated PP1 specifically dephosphorylated Ser68 of IRBIT. Phosphorylation of Ser68 was required for subsequent phosphorylation of Ser71 and Ser74, but the latter two sites were not targeted by PP1. We found that phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R|Given the importance of phosphorylation for the function of IRBIT in suppressing IP3R activity [7,10], in the present study, we searched for a protein phosphatase involved in the dephosphorylation and, hence, inactivation of IRBIT. We found that IRBIT contains a specific well-conserved binding site for PP1.
Publications: 1 Organism: Mus Musculus
+ PP1up-regulates activity img/direct-activation.png dephosphorylation GSK3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264820 Ser9 SGRPRTTsFAESCKP
pmid sentence
Anchored PP1 may relieve PKA-mediated inhibition of GSK3beta by dephosphorylating Ser-9, providing bi-directional control of AKAP220 complex formation in response to cAMP.
Publications: 1
+ PP1up-regulates img/direct-activation.png dephosphorylation CCND3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264662 Thr283 QGPSQTStPTDVTAI Homo sapiens
pmid sentence
These results support the hypothesis that pp1 constitutively keeps cyclin d3 in a stable, dephosphorylated state
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates activity img/direct-activation.png dephosphorylation NOS3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264668 Thr495 TGITRKKtFKEVANA Homo sapiens Endothelial Cell
pmid sentence
The increase in eNOS activity coincided with specific dephosphorylation of eNOS-Thr495, known to enhance eNOS activity. Inhibition of protein phosphatase 1 (PP1) by calyculin A, tautomycetin, or siRNA against PP1 reversed NF-induced eNOS-Thr495 dephosphorylation
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264664 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3)
Publications: 1 Organism: Homo Sapiens
+ NEK2down-regulates img/direct_inhibition.png phosphorylation PP1 0.501
Identifier Residue Sequence Organism Cell Line
SIGNOR-264655 Homo sapiens
pmid sentence
Pp1 is a substrate for nek2 and phosphorylation of pp1gamma(1) on two c-terminal sites reduces its phosphatase activity. / threonine-307 and -318 appear to be equally well phosphorylated by nek2
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates img/direct-activation.png binding CDC25C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264654 Homo sapiens
pmid sentence
Pp1 recognizes cdc25 directly by interacting with a pp1-binding motif in the cdc25 n-terminus.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates img/direct_inhibition.png dephosphorylation NEK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264667 Homo sapiens
pmid sentence
Nek2 is activated by autophosphorylation, and its dephosphorylation is catalyzed by pp1
Publications: 1 Organism: Homo Sapiens
+ CDK5down-regulates activity img/direct_inhibition.png phosphorylation PP1 0.482
Identifier Residue Sequence Organism Cell Line
SIGNOR-264649 Homo sapiens
pmid sentence
Pp1 isoforms contain an arg-pro-ile/val-thr-pro-pro-arg sequence near the c terminus, a known site of phosphorylation by cdc/cdk kinases, and phosphorylation attenuates phosphatase activity. Increasing doses of cdk2 resulted in increased phosphorylation of the thr-320 site. Phosphorylation of this site in pp1 corresponded to decreased pp1 activity.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation SP3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264652 Homo sapiens
pmid sentence
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.503
Identifier Residue Sequence Organism Cell Line
SIGNOR-269923 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264665 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates activity img/direct-activation.png dephosphorylation SLC4A4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264647 Mus musculus
pmid sentence
WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression. IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression,
Publications: 1 Organism: Mus Musculus
Tissue: Pancreas
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation SP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264669 Homo sapiens
pmid sentence
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression.
Publications: 1 Organism: Homo Sapiens
+ PPP1R9Bup-regulates activity img/direct-activation.png binding PP1 0.766
Identifier Residue Sequence Organism Cell Line
SIGNOR-269178 Homo sapiens Neuron
pmid sentence
In the present study, the interaction between PP1 and spinophilin, a neuronal protein that targets PP1 to dendritic spines, has been characterized. . These studies support the notion that spinophilin functions in vivo as a neuronal PP1 targeting subunit by directing the enzyme to postsynaptic densities and regulating its activity toward physiological substrates.
Publications: 1 Organism: Homo Sapiens
+ PPP1R2down-regulates img/direct_inhibition.png binding PP1 0.806
Identifier Residue Sequence Organism Cell Line
SIGNOR-264672 Homo sapiens
pmid sentence
Atm phosphorylates i-2 on serine 43, leading to the dissociation of the pp1-i-2 complex and the activation of pp1.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation PYG 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-267961 Homo sapiens Chang Cell
pmid sentence
GP is the first protein whose function was discovered to be regulated by reversible protein phosphorylation, which is controlled by phosphorylase kinase (PhK) and protein phosphatase 1 (PP1). Here we report that lysine acetylation negatively regulates GP activity by both inhibiting enzyme activity directly and promoting dephosphorylation
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
+ PPP1R1Cdown-regulates activity img/direct_inhibition.png binding PP1 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-275725
pmid sentence
IPP5, a novel inhibitor of protein phosphatase 1, suppresses tumor growth and progression of cervical carcinoma cells by inducing G2/M arrest
Publications: 1
+ PHACTR1up-regulates activity img/direct-activation.png binding PP1 0.551
Identifier Residue Sequence Organism Cell Line
SIGNOR-264656 Homo sapiens HUVEC Cell
pmid sentence
Phactr-1 was previously identified as protein phosphatase 1 (PP1) α-interacting protein that possesses actin-binding domains. We showed that Phactr-1 depletion decreased PP1 activity, disrupted the fine-tuning of actin polymerization and impaired lamellipodial dynamics. Taken together our results strongly suggest that Phactr-1 is a key component in the angiogenic process.
Publications: 1 Organism: Homo Sapiens
+ PP1down-regulates activity img/direct_inhibition.png dephosphorylation AKT 0.45
Identifier Residue Sequence Organism Cell Line
SIGNOR-264659 Homo sapiens
pmid sentence
Here, we identify PP1 as a serine/threonine phosphatase that associates with and dephosphorylates AKT in breast cancer cells|The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Publications: 1 Organism: Homo Sapiens
+ PPP1R3Bup-regulates img/direct-activation.png binding PP1 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-271736 Homo sapiens
pmid sentence
In the liver, PTG and PPP1R3B(GL)are expressed at roughly equivalent levels [55], and they jointly promote hepatic glycogen mobilization and storage. PTG overexpression significantly increased glycogen content, mainly due to its ability to promote the redistribution of PP1 and glycogen synthase to glycogen granules, significantly increasing GS activity and glycogen synthesis (Figure 2)
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ PPP1R3Cup-regulates img/direct-activation.png binding PP1 0.671
Identifier Residue Sequence Organism Cell Line
SIGNOR-271735 Homo sapiens
pmid sentence
In the liver, PTG and PPP1R3B(GL)are expressed at roughly equivalent levels [55], and they jointly promote hepatic glycogen mobilization and storage. PTG overexpression significantly increased glycogen content, mainly due to its ability to promote the redistribution of PP1 and glycogen synthase to glycogen granules, significantly increasing GS activity and glycogen synthesis (Figure 2)
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ CDK1down-regulates activity img/direct_inhibition.png phosphorylation PP1 0.561
Identifier Residue Sequence Organism Cell Line
SIGNOR-264648 Homo sapiens
pmid sentence
Both of these pp1 isoforms contain an arg-pro-ile/val-thr-pro-pro-arg sequence near the c terminus, a known site of phosphorylation by cdc/cdk kinases, and phosphorylation attenuates phosphatase activity.
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates img/direct-activation.png dephosphorylation IKZF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264663 Homo sapiens
pmid sentence
Ikarosis dephosphorylated by protein phosphatase 1 (pp1) via interaction at a consensus pp1-binding motif/ hyperphosphorylation of ikaros promotes its degradation by the ubiquitin/proteasome pathway
Publications: 1 Organism: Homo Sapiens
+ PP1up-regulates activity img/direct-activation.png dephosphorylation CFTR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264646 Mus musculus
pmid sentence
WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression. IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression,
Publications: 1 Organism: Mus Musculus
Tissue: Pancreas
+ PP1down-regulates img/direct_inhibition.png dephosphorylation AURKA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264651 Homo sapiens
pmid sentence
Pp1 is shown to dephosphorylate active stk15 and abolish its activity in vitro.
Publications: 1 Organism: Homo Sapiens
+ PPP1R8down-regulates activity img/direct_inhibition.png binding PP1 0.663
Identifier Residue Sequence Organism Cell Line
SIGNOR-264673 in vitro
pmid sentence
We have purified two of these nuclear inhibitors of PP-1 (NIPP-1a and NIPP-1b) until homogeneity.
Publications: 1 Organism: In Vitro
+ PP1down-regulates img/direct_inhibition.png dephosphorylation Gbeta 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269901 Homo sapiens
pmid sentence
P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases
Publications: 1 Organism: Homo Sapiens
+ AHCYL1up-regulates activity img/direct-activation.png relocalization PP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264645 Mus musculus
pmid sentence
WNK kinases acted as scaffolds to recruit SPAK, which phosphorylated CFTR and NBCe1-B, reducing their cell surface expression. IRBIT opposed the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression,
Publications: 1 Organism: Mus Musculus
Tissue: Pancreas
+ CDK2down-regulates activity img/direct_inhibition.png phosphorylation PP1 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-264650 Homo sapiens
pmid sentence
Both of these pp1 isoforms contain an arg-pro-ile/val-thr-pro-pro-arg sequence near the c terminus, a known site of phosphorylation by cdc/cdk kinases, and phosphorylation attenuates phosphatase activity
Publications: 1 Organism: Homo Sapiens
+ PPP1R1Bdown-regulates activity img/direct_inhibition.png binding PP1 0.677
Identifier Residue Sequence Organism Cell Line
SIGNOR-269869 Homo sapiens Neuron
pmid sentence
DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ 
Publications: 1 Organism: Homo Sapiens
a simple tooltip