Relation Results

Summary

Name Interferon-type-I
Primary ID SIGNOR-PF50
Type protein family
Formed by IFNA1, IFNA10, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNB1, IFNK, IFNW1
Relations 11
Pathways COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA

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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.20.2Interferon-type-IIFNARNUP98RAE1MOV10NfKb-p65/p50N3b6IRF3IFITMsIRF7

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Relations
Regulator
Mechanism
target
score ℹ
+ Interferon-type-Iup-regulates activity img/direct-activation.png binding IFNAR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260331 Homo sapiens
pmid sentence
Interferons have antiviral, antigrowth and immunomodulatory effects. The human type I interferons, IFN-alpha, IFN-beta, and IFN-omega, induce somewhat different cellular effects but act through a common receptor complex, IFNAR, composed of subunits IFNAR-1 and IFNAR-2. Human IFNAR-2 binds all type I IFNs but with lower affinity and different specificity than the IFNAR complex. Human IFNAR-1 has low intrinsic binding of human IFNs but strongly affects the affinity and differential ligand specificity of the IFNAR complex.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation NUP98 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260870 Homo sapiens
pmid sentence
Nup98/Nup96 (41) and Rae1 (17)are up regulated by interferons, which revert the mRNAexport block induced by VSV M protein
Publications: 1 Organism: Homo Sapiens
+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation RAE1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260869 Homo sapiens
pmid sentence
Nup98/Nup96 (41) and Rae1 (17)are up regulated by interferons, which revert the mRNAexport block induced by VSV M protein
Publications: 1 Organism: Homo Sapiens
+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MOV10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261137 Homo sapiens
pmid sentence
Mov10 is a processing body (P-body) protein and an interferon-stimulated gene that can affect replication of retroviruses, hepatitis B virus, and hepatitis C virus (HCV).
Publications: 1 Organism: Homo Sapiens
+ NfKb-p65/p50up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260329 Mus musculus
pmid sentence
Type 1 IFNs are induced in a cell type-specific manner through Toll-like receptor and RIG-I-like receptor pathways, both of which activate interferon regulatory factors (IRFs) and nuclear factor _B (NF-_B) transcription factors.
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ Ndown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260342
pmid sentence
The data presented here indicate that N protein inhibits interferon production, while ORF 3b and ORF 6 proteins are able to inhibit both interferon production and interferon signaling.
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ 3bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260343
pmid sentence
The data presented here indicate that N protein inhibits interferon production, while ORF 3b and ORF 6 proteins are able to inhibit both interferon production and interferon signaling.
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ 6down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260344
pmid sentence
The data presented here indicate that N protein inhibits interferon production, while ORF 3b and ORF 6 proteins are able to inhibit both interferon production and interferon signaling.
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ IRF3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260330 Mus musculus
pmid sentence
Type 1 IFNs are induced in a cell type-specific manner through Toll-like receptor and RIG-I-like receptor pathways, both of which activate interferon regulatory factors (IRFs) and nuclear factor _B (NF-_B) transcription factors.
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, EBV infection, Innate Immune Response, Inflammosome Activation, SARS-CoV ATTACHMENT AND ENTRY, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA
+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IFITMs 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260220 Homo sapiens
pmid sentence
The IFITM (interferon-induced transmembrane) proteins comprise a family of interferon-induced antiviral cell-intrinsic restriction factors with high constitutive expression in many cells, including barrier epithelial cells. As their names imply, the expression of human IFITM1, IFITM2, and IFITM3 is also strongly upregulated by both type I and type II interferons
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ IRF7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation Interferon-type-I 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263128 Homo sapiens
pmid sentence
Ikkalfa can also phosphorylate and activate interferon regulatory factor-7 (irf7), which is required for interferon-alfa (ifnalfa) production.
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, Innate Immune Response
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