Relation Results

Summary

Name TGFb
Primary ID SIGNOR-PF5
Type protein family
Formed by TGFB1, TGFB2, TGFB3
Relations 7
Pathways COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGFb in cancer

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Type: Score: Layout: SPV 
0.20.70.6150.20.20.7TGFbSNAI1AngiogenesisSMAD3/SMAD4SMAD3TGFBR2M2_polarization

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Relations
Regulator
Mechanism
target
score ℹ
+ TGFbup-regulates quantity by expression img/direct-activation.png transcriptional regulation SNAI1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265251 Homo sapiens HeLa Cell
pmid sentence
Epithelial-mesenchymal transition (EMT) takes place, namely fibrosis, development and cancer. the process of EMT is integral to a number of physiological and disease states. TGF-β1 is a major effector of this process that activates various key transcription factors such as Snai1.
Publications: 1 Organism: Homo Sapiens
+ TGFbup-regulates img/indirect-activation.png Angiogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270216
pmid sentence
More than a dozen different proteins have been identified as angiogenic activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, transforming growth factor (TGF)-α, TGF-β, tumor necrosis factor (TNF)-α, platelet-derived endothelial growth factor, granulocyte colony-stimulating factor, placental growth factor, interleukin-8, hepatocyte growth factor, and epidermal growth factor
Publications: 1
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ TGFbup-regulates quantity by expression img/indirect-activation.png transcriptional regulation SMAD3/SMAD4 0.615
Identifier Residue Sequence Organism Cell Line
SIGNOR-260428 Homo sapiens
pmid sentence
Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother against decapentaplegic (Smad) signaling. Different TGF-β signalings play different roles in fibrogenesis. TGF-β1 directly activates Smad signaling which triggers pro-fibrotic gene overexpression. Excessive studies have demonstrated that dysregulation of TGF-β1/Smad pathway was an important pathogenic mechanism in tissue fibrosis. Smad2 and Smad3 are the two major downstream regulator that promote TGF-β1-mediated tissue fibrosis, while Smad7 serves as a negative feedback regulator of TGF-β1/Smad pathway thereby protects against TGF-β1-mediated fibrosis.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGFb in cancer
+ TGFbup-regulates img/indirect-activation.png SMAD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-97123 Homo sapiens
pmid sentence
Because tgf-beta inhibits adipogenesis by signaling through smad3, we examined physical and functional interactions of smad3 and smad4 with c/ebpbeta, c/ebpdelta, and ppargamma2.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, TGFb in cancer
+ TGFbup-regulates activity img/direct-activation.png binding TGFBR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256178 Homo sapiens
pmid sentence
TGF-beta signaling mediates a wide range of biological activities in development and disease. TGF-beta ligands signal through heterodimeric type I and type II receptors (TGF-beta receptor type I [TbetaRI, also known as ALK5 and TGFBR1] and TbetaRII) that are members of the serine/threonine kinase family.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256179 Homo sapiens Macrophage
pmid sentence
TGFbeta signals are transmitted via a cell surface receptor complex consisting of the TGFbeta type I receptor (TbetaRI) and TGFbeta type II receptor (TbetaRII). To initiate signal transduction, TGFbeta binds to TbetaRII, which in turn recruits TbetaRI, leading to the formation of a tetrameric receptor complex.
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Fibrosis, Hepatocellular Tumor, Multiple sclerosis, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV FIBROSIS, Thyroid cancer, TGFb in cancer
+ M2_polarizationup-regulates img/indirect-activation.png TGFb 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263824 Homo sapiens Macrophage
pmid sentence
Macrophages and microglia show a high plasticity and have been arbitrarily classified into “M1” (proinflammatory) and “M2” (prorepair, anti-inflammatory) phenotypes depending on their activation state, although it is now widely accepted that this classification is hugely oversimplified, particularly for microglia, and only partially reflects the real situation. M2 polarized cells express a variety of anti-inflammatory mediators, such as IL-4, IL-10, and transforming growth factor-β (TGF-β), and contribute to immunoregulation
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
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