Relation Results

Summary

Name IFITMs
Primary ID SIGNOR-PF49
Type protein family
Formed by IFITM1, IFITM2, IFITM3, IFITM5
Relations 2
Pathways COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY

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Type: Score: Layout: SPV 
0.20.2Interferon-type-IIFITMsS

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Relations
Regulator
Mechanism
target
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+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IFITMs 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260220 Homo sapiens
pmid sentence
The IFITM (interferon-induced transmembrane) proteins comprise a family of interferon-induced antiviral cell-intrinsic restriction factors with high constitutive expression in many cells, including barrier epithelial cells. As their names imply, the expression of human IFITM1, IFITM2, and IFITM3 is also strongly upregulated by both type I and type II interferons
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ IFITMsdown-regulates activity img/indirect_inhibition.png S 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260230 Homo sapiens HEK-293 Cell, Huh-7.5 Cell
pmid sentence
All three IFITMs significantly inhibited the infection by lentiviral particles pseudotyped with IAV hemagglutinin 1 (H1) and neuraminidase 1 (N1) (IAVpp), Spike protein (S) of HCoV-229E (229Epp), HCoV-NL63 (NL63pp), SARS-CoV (SARSpp), and MERS-CoV (MERSpp) in both HEK293 (Fig. 1B) and Huh7.5 (Fig. 1C) cells.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
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