Relation Results

Summary

Name RAR
Primary ID SIGNOR-PF45
Type protein family
Formed by RARA, RARB, RARG
Relations 9
Pathways PPARgamma in cancer

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Type: Score: Layout: SPV 
0.20.7130.80.4120.80.710.7140.7140.2RARRXRA9-cis-retinoic acidTHRAall-trans-retinoic acidRXRBRXR

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Relations
Regulator
Mechanism
target
score ℹ
+ RARup-regulates img/direct-activation.png binding RXRA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269954 Homo sapiens
pmid sentence
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins
Publications: 1 Organism: Homo Sapiens
+ RXRAup-regulates img/direct-activation.png binding RAR 0.713
Identifier Residue Sequence Organism Cell Line
SIGNOR-269850 Homo sapiens
pmid sentence
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins
Publications: 1 Organism: Homo Sapiens
+ 9-cis-retinoic acidup-regulates activity img/direct-activation.png chemical activation RAR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259241 Homo sapiens
pmid sentence
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma).
Publications: 1 Organism: Homo Sapiens
+ THRAup-regulates img/direct-activation.png binding RAR 0.412
Identifier Residue Sequence Organism Cell Line
SIGNOR-269851 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
+ all-trans-retinoic acidup-regulates activity img/direct-activation.png chemical activation RAR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-256197 Homo sapiens
pmid sentence
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ RXRBup-regulates img/direct-activation.png binding RAR 0.71
Identifier Residue Sequence Organism Cell Line
SIGNOR-269852 Homo sapiens
pmid sentence
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins
Publications: 1 Organism: Homo Sapiens
+ RXRup-regulates activity img/direct-activation.png binding RAR 0.714
Identifier Residue Sequence Organism Cell Line
SIGNOR-256199 Homo sapiens
pmid sentence
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ RARup-regulates activity img/direct-activation.png binding RXR 0.714
Identifier Residue Sequence Organism Cell Line
SIGNOR-256198 Homo sapiens
pmid sentence
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ RARup-regulates img/direct-activation.png binding THRA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269955 Homo sapiens
pmid sentence
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs.
Publications: 1 Organism: Homo Sapiens
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