Relation Results

Summary

Name RXR
Primary ID SIGNOR-PF44
Type protein family
Formed by RXRA, RXRB, RXRG
Relations 6
Pathways PPARgamma in cancer

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Type: Score: Layout: SPV 
0.80.7150.80.20.80.715all-trans-retinoic acidRXRRARbexarotenePPARG9-cis-retinoic acid

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Relations
Regulator
Mechanism
target
score ℹ
+ all-trans-retinoic acidup-regulates activity img/direct-activation.png chemical activation RXR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-256190 Homo sapiens
pmid sentence
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ RXRup-regulates activity img/direct-activation.png binding RAR 0.715
Identifier Residue Sequence Organism Cell Line
SIGNOR-256199 Homo sapiens
pmid sentence
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ bexaroteneup-regulates activity img/direct-activation.png chemical activation RXR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259233 Homo sapiens Non-small Cell Lung Cancer Cell
pmid sentence
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.
Publications: 1 Organism: Homo Sapiens
+ RXRup-regulates activity img/direct-activation.png binding PPARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259057 Homo sapiens
pmid sentence
Although the three ppar subtypes are closely related and bind to similar dna response elements as heterodimers with the 9-cis retinoic acid receptor rxr, each subserves a distinct physiology
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ 9-cis-retinoic acidup-regulates activity img/direct-activation.png chemical activation RXR 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259240 Homo sapiens
pmid sentence
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma).
Publications: 1 Organism: Homo Sapiens
+ RARup-regulates activity img/direct-activation.png binding RXR 0.715
Identifier Residue Sequence Organism Cell Line
SIGNOR-256198 Homo sapiens
pmid sentence
Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins.
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
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