Relation Results

Summary

Name LATS1/2
Primary ID SIGNOR-PF43
Type protein family
Formed by LATS1, LATS2
Relations 20
Pathways Hippo in cancer, Hippo Signaling, Integrin Signaling, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.20.20.70.6270.20.7820.2750.760.20.6050.80.940.9190.20.9410.3910.20.80.8LATS1/2YAP1WWTR1F-actin_assemblySTK4VEPH1WWC1GCGNF2PRKACASTK3sphingosine 1-phosphateMOB1AMOB1BF2RMob1SRC(R)-adrenalinelysophosphatidic acids

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ LATS1/2down-regulates activity img/direct_inhibition.png phosphorylation YAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256188 Ser127 PQHVRAHsSPASLQL Homo sapiens
pmid sentence
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling, Integrin Signaling
+ LATS1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation YAP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277636 Ser397 TYHSRDEsTDSGLSM Homo sapiens HEK-293 Cell
pmid sentence
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling, Integrin Signaling
+ LATS1/2down-regulates activity img/direct_inhibition.png phosphorylation WWTR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256187 Ser89 AQHVRSHsSPASLQL Homo sapiens
pmid sentence
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling, Integrin Signaling
+ F-actin_assemblydown-regulates img/indirect_inhibition.png LATS1/2 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269861 Homo sapiens
pmid sentence
Ga12/13 recruitment of rho-gefs causes rhoa activation and f-actin assembly, which promotes lats1/lat2 inactivation by an unknown, but myosin-independent mechanism.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK4up-regulates img/direct-activation.png phosphorylation LATS1/2 0.627
Identifier Residue Sequence Organism Cell Line
SIGNOR-269859 Homo sapiens
pmid sentence
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ LATS1/2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation VEPH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269959 Homo sapiens Neuron
pmid sentence
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9
Publications: 1 Organism: Homo Sapiens
+ WWC1up-regulates activity img/direct-activation.png binding LATS1/2 0.782
Identifier Residue Sequence Organism Cell Line
SIGNOR-263659 Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ GCGup-regulates img/indirect-activation.png LATS1/2 0.275
Identifier Residue Sequence Organism Cell Line
SIGNOR-269857 Homo sapiens
pmid sentence
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz.
Publications: 1 Organism: Homo Sapiens
+ NF2up-regulates activity img/direct-activation.png binding LATS1/2 0.76
Identifier Residue Sequence Organism Cell Line
SIGNOR-263663 Homo sapiens
pmid sentence
The Hippo pathway tumor suppressor Merlin/NF2 is known to be regulated by phosphorylation. Here, the E3 ubiquitin ligase NEDD4L is shown to promote Hippo pathway activation via ubiquitination of Merlin.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ PRKACAup-regulates img/direct-activation.png phosphorylation LATS1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269863 Mus musculus NIH-3T3 Cell
pmid sentence
Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381.
Publications: 1 Organism: Mus Musculus
+ STK3up-regulates img/direct-activation.png phosphorylation LATS1/2 0.605
Identifier Residue Sequence Organism Cell Line
SIGNOR-269862 Homo sapiens
pmid sentence
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ sphingosine 1-phosphatedown-regulates img/indirect_inhibition.png LATS1/2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269864 Homo sapiens HEK-293 Cell
pmid sentence
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2.
Publications: 1 Organism: Homo Sapiens
+ MOB1Aup-regulates img/direct-activation.png binding LATS1/2 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-269866 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ MOB1Bup-regulates img/direct-activation.png binding LATS1/2 0.919
Identifier Residue Sequence Organism Cell Line
SIGNOR-269865 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ F2Rdown-regulates img/indirect_inhibition.png LATS1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269860 Homo sapiens HEK-293 Cell
pmid sentence
Par1 acts through g12/13 and rho gtpase to inhibit the lats1/2 kinase.
Publications: 1 Organism: Homo Sapiens
+ Mob1up-regulates activity img/direct-activation.png binding LATS1/2 0.941
Identifier Residue Sequence Organism Cell Line
SIGNOR-256186 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling
+ SRCdown-regulates activity img/direct_inhibition.png phosphorylation LATS1/2 0.391
Identifier Residue Sequence Organism Cell Line
SIGNOR-259056 Homo sapiens
pmid sentence
SRC can directly phosphorylate and inhibit LATS
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ VEPH1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LATS1/2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269858 Homo sapiens Neuron
pmid sentence
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9
Publications: 1 Organism: Homo Sapiens
+ (R)-adrenalineup-regulates img/indirect-activation.png LATS1/2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269867 Homo sapiens
pmid sentence
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz.
Publications: 1 Organism: Homo Sapiens
+ lysophosphatidic acidsdown-regulates img/indirect_inhibition.png LATS1/2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269868 Mus musculus MEF Cell
pmid sentence
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2.
Publications: 1 Organism: Mus Musculus
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