Relation Results

Summary

Name Mob1
Primary ID SIGNOR-PF42
Type protein family
Formed by MOB1A, MOB1B
Relations 6
Pathways Hippo in cancer, Hippo Signaling, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.9410.8550.20.8970.20.897Mob1LATS1/2STK3LATS1STK3/4LATS2STK4

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Relations
Regulator
Mechanism
target
score ℹ
+ Mob1up-regulates activity img/direct-activation.png binding LATS1/2 0.941
Identifier Residue Sequence Organism Cell Line
SIGNOR-256186 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling
+ STK3up-regulates img/direct-activation.png phosphorylation Mob1 0.855
Identifier Residue Sequence Organism Cell Line
SIGNOR-269855 Homo sapiens
pmid sentence
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ Mob1up-regulates img/direct-activation.png binding LATS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269958 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates activity img/direct-activation.png phosphorylation Mob1 0.897
Identifier Residue Sequence Organism Cell Line
SIGNOR-256185 Homo sapiens
pmid sentence
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling
+ Mob1up-regulates img/direct-activation.png binding LATS2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269957 Homo sapiens
pmid sentence
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK4up-regulates img/direct-activation.png phosphorylation Mob1 0.897
Identifier Residue Sequence Organism Cell Line
SIGNOR-269856 Homo sapiens
pmid sentence
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2mob1 interaction.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
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