Relation Results

Summary

Name STK3/4
Primary ID SIGNOR-PF41
Type protein family
Formed by STK3, STK4
Relations 26
Pathways Hippo in cancer, Hippo Signaling, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.20.80.2940.8020.20.2740.2640.20.20.4530.7350.3760.3470.20.4050.3760.8920.2820.20.3650.20.8970.4210.4050.7STK3/4MAP1LC3Bokadaic acidTAOK3RASSF1LATS1AKT3AKT2SAV1LATS2WWC1PPP2CATAOK1ABL1MOB1BAKT1TAOKTAOK2RAF1MOB1AMob1NF2AKTCell-Cell_contact

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ STK3/4down-regulates activity img/direct_inhibition.png phosphorylation MAP1LC3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273905 Thr50 QLPVLDKtKFLVPDH in vitro
pmid sentence
LC3B is phosphorylated at Thr-50 within the LDS by serine/threonine kinase (STK) 3 and STK4. Here, we identified LIR motifs in STK3 and atypical protein kinase Cζ (PKCζ) and never in mitosis A (NIMA)-related kinase 9 (NEK9). All three kinases phosphorylated LC3B Thr-50 in vitro A phospho-mimicking substitution of Thr-50 impaired binding of several LIR-containing proteins, such as ATG4B, FYVE, and coiled-coil domain-containing 1 (FYCO1), and autophagy cargo receptors p62/sequestosome 1 (SQSTM1) and neighbor of BRCA1 gene (NBR1).
Publications: 1 Organism: In Vitro
+ okadaic acidup-regulates img/indirect-activation.png STK3/4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269947 Homo sapiens
pmid sentence
Okadaic acid has been frequently used to enhance the phosphorylation of mst1 and mst2 and to trigger the activation of the hippo pathway.
Publications: 1 Organism: Homo Sapiens
+ TAOK3up-regulates img/direct-activation.png phosphorylation STK3/4 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-269949 Homo sapiens
pmid sentence
In addition, the thousand-and-one (tao) amino acids kinase or taok1 3 has been shown to directly phosphorylate and activate hpo or mst1/2
Publications: 1 Organism: Homo Sapiens
+ RASSF1up-regulates img/direct-activation.png binding STK3/4 0.802
Identifier Residue Sequence Organism Cell Line
SIGNOR-269950 Homo sapiens
pmid sentence
Mst1/2 is also activated by binding to Ras association domain family (RASSF) proteins, possibly owing to alteration of Mst1/2 subcellular localization.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates img/direct-activation.png phosphorylation LATS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270217 Homo sapiens HEK-293 Cell
pmid sentence
Since the N-terminal half of Lats1 (residues 1–588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ AKT3down-regulates img/direct_inhibition.png phosphorylation STK3/4 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-269941 Homo sapiens Breast Cancer Cell
pmid sentence
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation.
Publications: 1 Organism: Homo Sapiens
+ AKT2down-regulates img/direct_inhibition.png phosphorylation STK3/4 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-269937 Homo sapiens Breast Cancer Cell
pmid sentence
Akt phosphorylates mst2 at thr117 in vitro and in vivo, which leads to mst2 cleavage and kinase activity as well as nuclear translocation.
Publications: 1 Organism: Homo Sapiens
+ STK3/4up-regulates activity img/direct-activation.png phosphorylation SAV1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256184 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates img/direct-activation.png phosphorylation LATS2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270218 Homo sapiens
pmid sentence
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ WWC1up-regulates activity img/indirect-activation.png STK3/4 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-269951 Homo sapiens HEK-293 Cell
pmid sentence
These results shed light on the mechanism of Ex and Mer function and implicate Kibra as a potential tumor suppressor with relevance to neurofibromatosis.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ PPP2CAdown-regulates img/direct_inhibition.png dephosphorylation STK3/4 0.735
Identifier Residue Sequence Organism Cell Line
SIGNOR-269940 Homo sapiens
pmid sentence
Rassf1a apparently protects mst1/2 against inactivation by pp2a, the phosphatases that dephosphorylate the stimulatory thr-183 and thr-180 of mst1 andmst2, respectively.
Publications: 1 Organism: Homo Sapiens
+ TAOK1up-regulates img/direct-activation.png phosphorylation STK3/4 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-269938 Homo sapiens
pmid sentence
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2.
Publications: 1 Organism: Homo Sapiens
+ ABL1up-regulates img/direct-activation.png phosphorylation STK3/4 0.347
Identifier Residue Sequence Organism Cell Line
SIGNOR-269946 Homo sapiens Neuron
pmid sentence
We demonstrate that c-abl kinase phosphorylates mst2 at an evolutionarily conserved site, y81, within the kinase domain. We further show that the phosphorylation of mst2 by c-abl leads to the disruption of the interaction with raf-1 proteins and the enhancement of homodimerization of mst2 proteins. It thereby enhances the mst2 activation and induces neuronal cell death.
Publications: 1 Organism: Homo Sapiens
+ STK3/4up-regulates img/direct-activation.png phosphorylation MOB1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270221 Homo sapiens
pmid sentence
Mob1, which forms a complex with lats1/2, is also phosphorylated by mst1/2, resulting in an enhanced lats1/2 mob1 interaction.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ AKT1down-regulates img/direct_inhibition.png phosphorylation STK3/4 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-269945 Homo sapiens
pmid sentence
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2.
Publications: 1 Organism: Homo Sapiens
+ TAOKup-regulates activity img/direct-activation.png phosphorylation STK3/4 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-256182 Homo sapiens
pmid sentence
The thousand-and-one (TAO) amino acids kinase or TAOK1 – 3 has been shown to directly phosphorylate and activate Hpo or MST1/2.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling
+ SAV1up-regulates activity img/direct-activation.png binding STK3/4 0.892
Identifier Residue Sequence Organism Cell Line
SIGNOR-256183 Homo sapiens
pmid sentence
Mst is activated by binding of salvador (sav1, sav in drosophila), which is, in turn, also phosphorylated by mst.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263661 Homo sapiens HEK-293 Cell
pmid sentence
The human WW45 protein enhances MST1-mediated apoptosis in vivo In this model, hWW45 binds both MST1 and LATS through its coiled-coil domains and WW domains, respectively, and facilitates the phosphorylation of LATS by MST1. This model could explain the enhanced apoptotic efficacy of MST1 with the over-expression of hWW45 and the attenuated MST1-induced apoptosis with the down-regulation of endogenous hWW45.
Publications: 2 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ TAOK2up-regulates img/direct-activation.png phosphorylation STK3/4 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-269939 Homo sapiens
pmid sentence
In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2.
Publications: 1 Organism: Homo Sapiens
+ STK3/4down-regulates img/direct_inhibition.png phosphorylation ABL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270219 Homo sapiens
pmid sentence
Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3
Publications: 1 Organism: Homo Sapiens
+ RAF1down-regulates img/direct_inhibition.png binding STK3/4 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-269942 Homo sapiens
pmid sentence
Raf-1 prevents dimerization and phosphorylation of the activation loop of mst2 independently of its protein kinase activity.Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (mst2)
Publications: 1 Organism: Homo Sapiens
+ STK3/4up-regulates img/direct-activation.png phosphorylation MOB1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270220 Homo sapiens HEK-293 Cell
pmid sentence
These findings indicate that the phosphorylation of mob1 at thr74 by mst2 is essential to make a complex of mob1, mst2 and ndr1, and to fully activate ndr1
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ STK3/4up-regulates activity img/direct-activation.png phosphorylation Mob1 0.897
Identifier Residue Sequence Organism Cell Line
SIGNOR-256185 Homo sapiens
pmid sentence
Mob1, when phosphorylated by MST1/2, binds to the autoinhibitory motif in Lats1/2, which in turn leads to the phosphorylation of the Lats activation loop (Lats1 S909 and Lats2 S872) and thereby an increase of their kinase activity
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling
+ NF2up-regulates activity img/direct-activation.png binding STK3/4 0.421
Identifier Residue Sequence Organism Cell Line
SIGNOR-269948 Mus musculus Cardiomyocyte Cell Line
pmid sentence
NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart.
Publications: 1 Organism: Mus Musculus
Pathways:Hippo Signaling
+ AKTdown-regulates img/direct_inhibition.png phosphorylation STK3/4 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-269944 Homo sapiens
pmid sentence
We determined that mst2 phosphorylation by akt limits mst2 activity in two ways: first, by blocking its binding to rassf1a and by promoting its association into the raf-1 inhibitory complex, and second, by preventing homodimerization of mst2, which is needed for its activation. we identified t117 and t384 as akt phosphorylation sites in mst2.
Publications: 1 Organism: Homo Sapiens
+ Cell-Cell_contactup-regulates img/indirect-activation.png STK3/4 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269943 Homo sapiens
pmid sentence
In response to growth inhibitory signal (e.g. cell–cell contact), MST1/2 in active form phosphorylates LATS1/2 that sequentially phosphorylates YAP at Ser-127.
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
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