Relation Results

Summary

Name Wnt
Primary ID SIGNOR-PF40
Type protein family
Formed by WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B
Relations 7
Pathways Hepatocellular Tumor, Satellite: WNT, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.7860.20.20.20.8010.8340.2SFRP1WntCTNNB1LRP5FZD3LPR5/6FrizzledLRP6

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Relations
Regulator
Mechanism
target
score ℹ
+ SFRP1down-regulates img/direct_inhibition.png binding Wnt 0.786
Identifier Residue Sequence Organism Cell Line
SIGNOR-262527 Homo sapiens T-lymphocyte
pmid sentence
Frp inhibits wnt signaling through interactions with wnt and/or formation of nonfunctional complexes with the frizzled receptor. here we demonstrate that frza, a sfrp that is highly expressed in vascular endothelium and a variety of epithelium, specifically binds to wnt-1 protein, but not wnt-5a protein, and modulates wnt-1 signaling.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3
+ Wntup-regulates quantity by stabilization img/indirect-activation.png CTNNB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256240
pmid sentence
The central player in the canonical Wnt cascade is β-catenin, a cytoplasmic protein whose stability is regulated by the destruction complex.
Publications: 1
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ Wntup-regulates img/direct-activation.png binding LRP5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269961 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ Wntup-regulates img/direct-activation.png binding FZD3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269960 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
+ Wntup-regulates activity img/direct-activation.png binding LPR5/6 0.801
Identifier Residue Sequence Organism Cell Line
SIGNOR-256174 Homo sapiens
pmid sentence
FZD and LRP5/6 transduce Wnt signal via engaging downstream cytoplasmic components, among which two scaffolding proteins, Dishevelled and Axin, have prominent roles.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Wnt in cancer
+ Wntup-regulates activity img/direct-activation.png binding Frizzled 0.834
Identifier Residue Sequence Organism Cell Line
SIGNOR-256173 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ Wntup-regulates activity img/direct-activation.png binding LRP6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-131577 Homo sapiens
pmid sentence
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
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