Relation Results

Summary

Name SMAD1/5/8
Primary ID SIGNOR-PF35
Type protein family
Formed by SMAD1, SMAD5, SMAD9
Relations 8
Pathways FAP: BMP, Myofiber: BMP, Osteoblast: BMP

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Type: Score: Layout: SPV 
0.7750.20.780.7010.6930.7620.672BMPR1ASMAD1/5/8SMAD4SMURF2BMPR1BBMP2SMURF1SMAD1/5/8/SMAD4

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Relations
Regulator
Mechanism
target
score ℹ
+ BMPR1Aup-regulates activity img/direct-activation.png phosphorylation SMAD1/5/8 0.775
Identifier Residue Sequence Organism Cell Line
SIGNOR-255830 Homo sapiens C2C12 Cell, HEK-293-EBNA Cell, L-6 Myoblast Cell
pmid sentence
In this study, we isolated human Smad5 and found that Smad5 was involved in BMP-2 signaling cascades, which mediate the bone-inducing effects of BMP-2. Smad5 was directly serine-phosphorylated by BMPIR through a physical interaction. The activated Smad5 subsequently formed a complex with DPC4, and this complex was then translocated to the nucleus.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255831 Mus musculus C3H10T1/2 Cell
pmid sentence
The expression of CA-BMPr1A and CA-BMPr1B mRNA was confirmed by RT-PCR using appropriate primers to distinguish expression of the constitutively active receptors from endogenous BMP receptors; specific antibodies for these receptors were not available. However, the functional effects of their expression, i.e., phosphorylation of Smad1/5/8 and p38 MAPK, verify overexpression of the constitutively active receptors (Fig. 3B). Thus, their overexpression provoked a substantial rise in the phosphorylation of Smad1/5/8 and p38 MAPK, known downstream phosphorylated intermediates in the BMP signaling pathway (Fig. 3B) (16, 17).
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ SMAD1/5/8up-regulates img/direct-activation.png binding SMAD4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269952 Homo sapiens
pmid sentence
Upon ligand binding, the specific heteromeric transmembrane serine/threonine kinase receptor complexes undergo phosphorylation/activation and subsequently phosphorylate the two ser residues in the c-terminal sxs motif of specific r-smads, smad1/5/8 for bmp pathway and smad2/3 for tgf-_/activin signaling. The activated r-smads then associate with co-smad, smad4. The heteromeric complexes translocate into the nucleus, where they bind to dna directly or indirectly to regulate the transcription of specific genes.
Publications: 1 Organism: Homo Sapiens
+ SMURF2down-regulates img/direct_inhibition.png ubiquitination SMAD1/5/8 0.78
Identifier Residue Sequence Organism Cell Line
SIGNOR-269845 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
+ BMPR1Bup-regulates img/direct-activation.png phosphorylation SMAD1/5/8 0.701
Identifier Residue Sequence Organism Cell Line
SIGNOR-269846 Homo sapiens
pmid sentence
The c terminus of smad1, which is phosphorylated directly by the bmp type i receptor at the ssvs sequence in contrast to the bmp-stimulated phosphorylation of smad1, which affects carboxy-terminal serines and induces nuclear accumulation of smad1, erk-mediated phosphorylation specifically inhibits the nuclear accumulation of smad1.
Publications: 1 Organism: Homo Sapiens
+ BMP2up-regulates img/indirect-activation.png SMAD1/5/8 0.693
Identifier Residue Sequence Organism Cell Line
SIGNOR-269848 Homo sapiens
pmid sentence
Neogenin, a transmembranous protein, was reported to regulate bmp receptor association with lipid raft, where bmp induces canonical smad1/5/8 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ SMURF1down-regulates img/direct_inhibition.png ubiquitination SMAD1/5/8 0.762
Identifier Residue Sequence Organism Cell Line
SIGNOR-269847 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
+ SMAD1/5/8form complex img/form-complex.png binding SMAD1/5/8/SMAD4 0.672
Identifier Residue Sequence Organism Cell Line
SIGNOR-255838 Homo sapiens
pmid sentence
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus.
Publications: 1 Organism: Homo Sapiens
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