Relation Results

Summary

Name PIM
Primary ID SIGNOR-PF34
Type protein family
Formed by PIM1, PIM2, PIM3
Relations 26
Pathways Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML

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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.2690.20.4010.80.420.20.70.2PIMH3C1BADMDM2FOXO3RELAMAP3K5MARK3CDKN1ACDKN1BPRKACAERGFOXOSGI-1776STAT5AHistone H3ApoptosisRPS19

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259409 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Pim1-dependent phosphorylation of histone h3 at serine 10 is required for myc-dependent transcriptional activation and oncogenic transformation.
Publications: 1 Organism: Homo Sapiens
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259423 Ser118 GRELRRMsDEFVDSF Homo sapiens HEK-293 Cell
pmid sentence
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. pim kinases are constitutively active when expressed in HEK-293 cells and are able to phosphorylate the Bcl-2 family member Bad on three residues, Ser112, Ser136 and Ser155 in vitro and in cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259421 Ser75 EIRSRHSsYPAGTED Homo sapiens
pmid sentence
All three Pim kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK-293 cells. This would be consistent with the proposed function of Pim kinases in promoting cell proliferation and preventing cell death.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259422 Ser99 PFRGRSRsAPPNLWA Homo sapiens HEK-293 Cell
pmid sentence
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL. pim kinases are constitutively active when expressed in HEK-293 cells and are able to phosphorylate the Bcl-2 family member Bad on three residues, Ser112, Ser136 and Ser155 in vitro and in cells.
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ PIMdown-regulates img/direct_inhibition.png phosphorylation BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259418 Ser118 GRELRRMsDEFVDSF Homo sapiens
pmid sentence
Similar to pim1, pim2 phosphorylates bad, which antagonizes the pro-apoptotic function of bax
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ PIMup-regulates img/direct-activation.png phosphorylation MDM2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259433 Ser166 SSRRRAIsETEENSD Homo sapiens Lymphoma Cell
pmid sentence
Additionally, the pim kinases phosphorylate mdm2 in vitro and in cultured cells at ser166 and ser186, two previously identified targets of other signaling pathways, including akt.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259434 Ser186 RQRKRHKsDSISLSF Homo sapiens Lymphoma Cell
pmid sentence
Additionally, the pim kinases phosphorylate mdm2 in vitro and in cultured cells at ser166 and ser186, two previously identified targets of other signaling pathways, including akt.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ PIMdown-regulates img/direct_inhibition.png phosphorylation FOXO3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259429 Ser253 APRRRAVsMDNSNKY Homo sapiens
pmid sentence
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ PIMup-regulates img/direct-activation.png phosphorylation RELA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259411 Ser276 SMQLRRPsDRELSEP Homo sapiens
pmid sentence
In this study we show that phosphorylation of rela/p65 at ser276 prevents its degradation by ubiquitin-mediated proteolysis. importantly, we identify pim-1 as a further kinase responsible for the phosphorylation of rela/p65 at ser276.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ PIMdown-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259410 Ser83 ATRGRGSsVGGGSRR Homo sapiens NCI-H1299 Cell
pmid sentence
Pim1 phosphorylates and negatively regulates ask1-mediated apoptosispim1 phosphorylation of ask1 on ser83 inhibited ask1-mediated c-jun n-terminal kinase phosphorylation
Publications: 1 Organism: Homo Sapiens
+ PIMdown-regulates img/direct_inhibition.png phosphorylation MARK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259432 Ser96 KTQLNPTsLQKLFRE Homo sapiens
pmid sentence
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259431 Thr90 AIKIIDKtQLNPTSL Homo sapiens
pmid sentence
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-259430 Thr95 DKTQLNPtSLQKLFR Homo sapiens
pmid sentence
Here we show that the protein kinase cdc25 c-associated kinase 1 (c-tak1) is a binding partner and a substrate of pim-1.
Publications: 3 Organism: Homo Sapiens
+ PIMup-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259424 Thr145 QGRKRRQtSMTDFYH Homo sapiens
pmid sentence
Pim-2 phosphorylation of p21(cip1/waf1) enhances its stability and inhibits cell proliferation in hct116 cellshere we demonstrate that like pim-1, pim-2 also phosphorylates the cell cycle inhibitor p21(cip1/waf1) (p21) on thr145 in vitro and in vivo
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ PIMdown-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259426 Thr157 GIRKRPAtDDSSTQN Homo sapiens
pmid sentence
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259425 Thr198 PGLRRRQt Homo sapiens
pmid sentence
We show, herein, that all the pim family members (pim1, pim2, and pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(kip1) at threonine-157 and threonine-198 residues in cells and in vitro.|Pim kinases promote cell cycle progression and tumorigenesis by down-regulating p27(Kip1) expression at both transcriptional and posttranslational levels.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259428 Thr32 QSRPRSCtWPLQRPE Homo sapiens
pmid sentence
Pim1s expression induced the phosphorylation of foxo3a (fig. 5a and b) and inactivated its transcriptional activity (fig. 5c). A previous report showed that phosphorylation at t32, s253, and s315 residues in foxo3a induced 14-3-3 binding, nuclear export, and proteasomemediated degradation (42).
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ PRKACAup-regulates activity img/direct-activation.png phosphorylation PIM 0.269
Identifier Residue Sequence Organism Cell Line
SIGNOR-259413 Homo sapiens HEK-293 Cell
pmid sentence
In this study, we found that PKCα stabilized and activated PIM-1L by phosphorylation at Ser65. The PIM-1L phosphorylation suppressed sotrastaurin-induced apoptosis. These findings suggest that PKCα promotes cell survival and proliferation by upregulating PIM-1L in acute myeloid leukemia.
Publications: 1 Organism: Homo Sapiens
+ ERGup-regulates quantity by expression img/direct-activation.png transcriptional regulation PIM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259408 Homo sapiens Prostate Epithelium Cell Line
pmid sentence
ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells. The up-regulation of PIM1 induced by tERG over-expression significantly modified Cyclin B1 levels and increased the percentage of aneuploid cells in the RWPE-1 cell line after taxane-based treatment. Here we provide the first evidence for an ERG-mediated PIM1 up-regulation in prostate cells in vitro and in vivo, suggesting a direct effect of ERG transcriptional activity in the alteration of genetic stability.
Publications: 1 Organism: Homo Sapiens
+ PIMdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.401
Identifier Residue Sequence Organism Cell Line
SIGNOR-259427 Homo sapiens
pmid sentence
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ SGI-1776down-regulates img/direct_inhibition.png chemical inhibition PIM 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259435 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ STAT5Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-255733 Homo sapiens MV4-11 Cell
pmid sentence
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously reported that activation of STAT5 confers resistance to PI3K/Akt inhibitors on the FLT3-ITD-positive AML cell line MV4-11 and 32D cells driven by FLT3-ITD (32D/ITD) but not by FLT3 mutated in the tyrosine kinase domain (32D/TKD). Here, we report the involvement of Pim kinases expressed through STAT5 activation in acquisition of this resistance.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ STAT5Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation PIM 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-259436 Homo sapiens
pmid sentence
Pim-1 is know to be up regulated by signal transducer and activator of transcription 5 (stat5)
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265365 Homo sapiens
pmid sentence
Pim1-dependent phosphorylation of histone h3 at serine 10 is required for myc-dependent transcriptional activation and oncogenic transformation.
Publications: 1 Organism: Homo Sapiens
+ PIMdown-regulates img/indirect_inhibition.png Apoptosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255732 Homo sapiens Hematopoietic Cell
pmid sentence
The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting because recent data point to an important role of Pim kinases in the antiapoptosis of hematopoietic cells.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ PIMup-regulates img/direct-activation.png phosphorylation RPS19 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259412 Homo sapiens HEK-293 Cell
pmid sentence
The pim-1/rps19 interaction was demonstrated both in vitro and in living cells and led to phosphorylation of rps19 in an in vitro kinase assay.
Publications: 1 Organism: Homo Sapiens
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