Relation Results

Summary

Name GPCR
Primary ID SIGNOR-PF33
Type protein family
Formed by
Relations 4
Pathways Neutrophils: G-protein-coupled receptor, Neurotransmitters release, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.20.20.2GPCRGNB/GNGGNA13GNAI1

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Relations
Regulator
Mechanism
target
score ℹ
+ GPCRup-regulates activity img/direct-activation.png binding GNB/GNG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255007 Homo sapiens
pmid sentence
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the G gamma/beta subunit. G-protein-coupled receptors in neutrophils primarily signal through the Gβγ heterodimer, activating two parallel pathways through PLCβ2/3 and PI3Kγ.
Publications: 1 Organism: Homo Sapiens
+ GPCRup-regulates activity img/direct-activation.png binding GNA13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277655 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ GPCRup-regulates img/direct-activation.png GNAI1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255009 Homo sapiens
pmid sentence
Activation of those receptors triggers the dissociation of the GPCR-specific Gα subunit from the shared Gβγ dimer and concomitant activation of various signal transduction pathways by both G-protein fragments
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ GPCRup-regulates activity img/direct-activation.png binding GNAI1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255006 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
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