Relation Results

Summary

Name SRC_kinase_family
Primary ID SIGNOR-PF32
Type protein family
Formed by BLK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, YES1
Relations 9
Pathways Mast cell: FCERI, Mast cell: SCF

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Type: Score: Layout: SPV 
0.20.20.20.5970.70.580.7SRC_kinase_familyKLF16KCND3SLC24A2FCER1DegranulationKITChemotaxis

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRC_kinase_familyup-regulates activity img/direct-activation.png phosphorylation KLF16 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275586 Tyr10 AAVACVDyFAADVLM
pmid sentence
Phosphorylation of KLF16 was confirmed by in vivo (32)P incorporation and controlled by a Y10F site-directed mutant. Inhibition of Src-type tyrosine kinase signaling as well as the nonphosphorylatable Y10F mutation disrupted KLF16-mediated gene silencing, demonstrating that its function is regulatable rather than constitutive.
Publications: 1
+ SRC_kinase_familyup-regulates activity img/direct-activation.png phosphorylation KCND3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275566 Tyr108 GKLHYPRyECISAYD
pmid sentence
Our results demonstrate that human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue|We found that human atrial I(to) was inhibited by the broad-spectrum PTK inhibitor genistein, the selective epidermal growth factor receptor (EGFR) kinase inhibitor AG556, and the Src-family kinases inhibitor PP2.
Publications: 1
+ SRC_kinase_familyup-regulates quantity img/direct-activation.png phosphorylation SLC24A2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264387 Tyr364 LAEELGSyGKLKYYD Homo sapiens Neuron
pmid sentence
Src family kinase-mediated Tyr-365 phosphorylation of NCKX2 regulates its surface expression. PP2 facilitated the endocytosis of NCKX2 in both the somatodendritic and axonal compartments, suggesting that tyrosine phosphorylation of NCKX2 by SFK negatively regulates its endocytosis. Supporting this idea, activation of SFK enhanced the NCKX activity in the proximal dendrites of dentate granule cells (GCs). These results suggest that endocytosis of somatodendritic NCKX2 is regulated by SFK-dependent phosphorylation of Tyr-365.
Publications: 1 Organism: Homo Sapiens
+ FCER1up-regulates img/indirect-activation.png SRC_kinase_family 0.597
Identifier Residue Sequence Organism Cell Line
SIGNOR-254957 Homo sapiens Mast Cell
pmid sentence
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits
Identifier Residue Sequence Organism Cell Line
SIGNOR-254955 Homo sapiens Mast Cell
pmid sentence
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits
Identifier Residue Sequence Organism Cell Line
SIGNOR-254963 Homo sapiens Mast Cell
pmid sentence
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits
Publications: 3 Organism: Homo Sapiens
+ SRC_kinase_familyup-regulates img/indirect-activation.png Degranulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254956 Homo sapiens
pmid sentence
So, the association of aggregated FcεRI with the preferentially activated LYN in lipid rafts might be sufficient to shift the equilibrium of FcεRI from a nonphosphorylated state to a phosphorylated state, thereby initiating FcεRI-mediated degranulation
Publications: 1 Organism: Homo Sapiens
+ KITup-regulates img/direct-activation.png phosphorylation SRC_kinase_family 0.58
Identifier Residue Sequence Organism Cell Line
SIGNOR-254995 Homo sapiens
pmid sentence
Binding of SCF to c-Kit leads to a rapid increase in SFK kinase activity
Publications: 1 Organism: Homo Sapiens
+ SRC_kinase_familyup-regulates img/indirect-activation.png Chemotaxis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-254996 Homo sapiens
pmid sentence
The SFK family of tyrosine kinases is named after its prototypic family member c-Src. SCF-induced chemotaxis of Mo7 cells was dependent on SFK activity
Publications: 1 Organism: Homo Sapiens
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