Relation Results

Summary

Name NOTCH
Primary ID SIGNOR-PF30
Type protein family
Formed by NOTCH1, NOTCH2, NOTCH3, NOTCH4
Relations 65
Pathways Acute Myeloid Leukemia, FLT3-ITD in AML, Satellite: NOTCH

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Type: Score: Layout: SPV 
0.7350.950.2910.7290.880.790.630.6290.6260.3180.4050.20.70.20.390.6080.790.630.20.5910.9490.7730.4310.20.20.3820.470.20.20.2630.20.20.20.4870.5660.20.390.4590.6310.7180.20.9210.6650.3610.5340.5850.20.3780.20.330.20.7730.20.5710.20.858POFUT1NOTCHRBPJ/NOTCHKPNA4ADAM17MAML3PSEN1JAG2JAG1DLL1XXYLT1DYRK1APIN1ProliferationHEY2GXYLT2YY1NUMBITCHPOGLUT1RBPJADAM10EIF3FIL7RLFNGFOXO3DLL3KPNA6PAX7SIAH1HEY1FOXOEGFL7HIF1ANMAML2SDC3CCNCFBXW7SMAD3HEYLMAML1gamma-secretaseBMPR1A/1B/2CDK8KAT2BSNW1CKM complexADAM19KPNA3CCND1DTX1BCL2CNTN6HES1

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Relations
Regulator
Mechanism
target
score ℹ
+ POFUT1up-regulates img/direct-activation.png binding NOTCH 0.735
Identifier Residue Sequence Organism Cell Line
SIGNOR-254326 Homo sapiens
pmid sentence
Notch_ is modified in its epidermal growth factor-like domains by the addition of_ fucose_ to serine or threonine residues. O-fucosylation is mediated by protein o-fucosyltransferase 1 and down-regulation of this enzyme by rna interference or mutation of the ofut1 gene in drosophila or by mutation of the pofut1 gene in mouse prevents notch signaling.
Publications: 1 Organism: Homo Sapiens
+ NOTCHform complex img/form-complex.png binding RBPJ/NOTCH 0.95
Identifier Residue Sequence Organism Cell Line
SIGNOR-255363
pmid sentence
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-Jk and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255377
pmid sentence
The released NICD translocates directly to the nucleus, where it forms a transcriptional complex with the DNA-binding protein CSL (CBF1, Suppressor of Hairless, Lag1), Mastermind (Mam) and transcriptional co-activators to drive the expression of Notch target genes
Identifier Residue Sequence Organism Cell Line
SIGNOR-255364
pmid sentence
NICD is translocated to the nucleus where it binds recombining binding protein-Jj (RBP-Jj)
Identifier Residue Sequence Organism Cell Line
SIGNOR-255380
pmid sentence
Notch is cleaved and translocates to the nucleus, where it activates a family of transcription factors, exemplified by Suppressor of Hairless and CBF/RJBk
Publications: 4
Tissue: Skeletal Muscle
+ KPNA4up-regulates img/direct-activation.png relocalization NOTCH 0.291
Identifier Residue Sequence Organism Cell Line
SIGNOR-254322 Homo sapiens
pmid sentence
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7.
Publications: 1 Organism: Homo Sapiens
+ ADAM17up-regulates img/direct-activation.png cleavage NOTCH 0.729
Identifier Residue Sequence Organism Cell Line
SIGNOR-255370 Mus musculus
pmid sentence
Two ADAMs have been implicated in the S2 cleavage of Notch. In Drosophila, ADAM10 ortholog Kuzbanian is the main protease mediating Notch processing [35–38]. In mouse cells in vitro, ADAM17, and not ADAM10, appears to be a protease responsible for Notch cleavage
Identifier Residue Sequence Organism Cell Line
SIGNOR-255371 Mus musculus
pmid sentence
Receptor–ligand engagement triggers a second NECD cleavage (S2 cleavage) by a metalloproteinase ADAM (known as Kuzbanian in Drosophila melanogaster)
Publications: 2 Organism: Mus Musculus
+ MAML3up-regulates img/direct-activation.png binding NOTCH 0.88
Identifier Residue Sequence Organism Cell Line
SIGNOR-254323 Homo sapiens
pmid sentence
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors.
Publications: 1 Organism: Homo Sapiens
+ PSEN1up-regulates img/direct-activation.png cleavage NOTCH 0.79
Identifier Residue Sequence Organism Cell Line
SIGNOR-254308 Homo sapiens
pmid sentence
Presenilin-1 (ps1), a polytopic membrane protein primarily localized to the endoplasmic reticulum, is required for efficient proteolysis of both notch and beta-amyloid precursor protein (app) within their trans- membrane domains.
Publications: 1 Organism: Homo Sapiens
+ JAG2up-regulates img/direct-activation.png binding NOTCH 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-269935 Homo sapiens
pmid sentence
Binding of delta1, jagged1, and jagged2 to notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of notch2
Publications: 1 Organism: Homo Sapiens
+ JAG1up-regulates img/direct-activation.png binding NOTCH 0.629
Identifier Residue Sequence Organism Cell Line
SIGNOR-269936 Homo sapiens
pmid sentence
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch.
Publications: 1 Organism: Homo Sapiens
+ DLL1up-regulates img/direct-activation.png binding NOTCH 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-255368
pmid sentence
When activated by its ligands (Delta and Jagged in vertebrates and Serrate in invertebrates), the intracellular portion of Notch is cleaved and translocates to the nucleus
Identifier Residue Sequence Organism Cell Line
SIGNOR-255369
pmid sentence
The NECD undergoes O-linked glycosylation during Notch synthesis and secretion, which is crucial for proper folding of the Notch receptor and the interaction with its ligand DSL (Delta, Serrate, Lag-2)(Rana and Haltiwanger, 2011). The Notch receptor on the signal-receiving cell binds directly to ligands located on the apposing signal-sending cell
Publications: 2
Tissue: Skeletal Muscle
+ XXYLT1up-regulates img/direct-activation.png binding NOTCH 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-254333 Homo sapiens
pmid sentence
Xxylt1 acts on the xyl1,3glc-o-linked glycan of notch egf domains.
Publications: 1 Organism: Homo Sapiens
+ DYRK1Adown-regulates img/direct_inhibition.png phosphorylation NOTCH 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-254313 Homo sapiens
pmid sentence
Dyrk1a physically interacts with the nicd inducing its phosphorylation in the ankyrin domain, thereby attenuating notch .
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254342 Homo sapiens Breast Cancer Cell
pmid sentence
Previously, we have shown that commitment of the C2C12 cells to the osteoblastic lineage occurs around 24h after BMP treatment, when the osteoblast specific transcription factor Cbfa1 and the novel osteoblast related genes Tcf7 and Hey1 become regulated
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates img/indirect-activation.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-255376
pmid sentence
Taken together, these results show that Notch-1 activity promotes myogenic cell proliferation and that attenuation of Notch-1 activity by its antagonist Numb causes cells to exit from the cell cycle, express MRFs, and undergo myogenic differentiation.
Publications: 1
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEY2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254338 Homo sapiens
pmid sentence
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Publications: 1 Organism: Homo Sapiens
+ GXYLT2up-regulates img/direct-activation.png binding NOTCH 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-254314 Homo sapiens
pmid sentence
Recently, we have shown (28) that two members of the human glycosyltransferase 8 family (gt8) (29), gxylt1 and gxylt2 (glucoside-xylosyltransferase 1/2), are able to transfer the first alfa1,3-linked xylose to o-glucosylated mammalian notch egf repeats.
Publications: 1 Organism: Homo Sapiens
+ YY1down-regulates activity img/direct_inhibition.png binding NOTCH 0.608
Identifier Residue Sequence Organism Cell Line
SIGNOR-254305 Homo sapiens K-562 Cell
pmid sentence
Taken together, these results indicate that transcription factor YY1 may modulate Notch signaling via association with the high molecular weight Notch complex [..] both YY1 and N1IC were present in a large complex of the nucleus to suppress the luciferase reporter activity transactivated by Notch signaling.
Publications: 1 Organism: Homo Sapiens
+ NUMBdown-regulates img/direct_inhibition.png NOTCH 0.79
Identifier Residue Sequence Organism Cell Line
SIGNOR-255375
pmid sentence
Therefore, these genetic data further support the hypothesis that activation of Notch-1 promotes a less committed myogenic phenotype and that the attenuation of Notch-1 activity by Numb promotes progression along the myogenic lineage toward a myoblast cell fate.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255374
pmid sentence
Numb is an inhibitor of Notch signaling that interacts with the intracellular portion of Notch and antagonizes its activity by preventing nuclear translocation
Publications: 2
Tissue: Skeletal Muscle
+ ITCHdown-regulates img/direct_inhibition.png ubiquitination NOTCH 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-254331 Homo sapiens
pmid sentence
Itch binds to the n-terminal portion of the notch intracellular domain via its ww domains and promotes ubiquitination of notch through its hect ubiquitin ligase domain.
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ NOTCHup-regulates img/direct-activation.png binding MAML3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254346 Homo sapiens
pmid sentence
Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages
Publications: 1 Organism: Homo Sapiens
+ POGLUT1up-regulates img/direct-activation.png glycosylation NOTCH 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-254319 Homo sapiens
pmid sentence
O-glucosylation of epidermal growth factor-like (egf) repeats in the extracellular domain of notch is essential for notch function. A udp-glucose:protein o-glucosyltransferase (poglut/rumi) transfers o-glucose to serine within the o-glucose consensus.
Publications: 1 Organism: Homo Sapiens
+ RBPJdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NOTCH 0.949
Identifier Residue Sequence Organism Cell Line
SIGNOR-255373
pmid sentence
In the absence of NICD, CSL forms complexes with a variety of co-repressors to suppress the transcription of Notch target genes
Publications: 1
+ ADAM10up-regulates activity img/direct-activation.png cleavage NOTCH 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-259836 Homo sapiens
pmid sentence
One of the most important and best characterized ADAM10 substrates is the Notch receptor [16]. After ligand binding to the Notch receptor, ADAM10 liberates the ectodomain and the membrane remaining part is processed by the γ-secretase complex, which releases a Notch Intracellular Domain (NICD).
Publications: 1 Organism: Homo Sapiens
+ EIF3Fup-regulates img/direct-activation.png deubiquitination NOTCH 0.431
Identifier Residue Sequence Organism Cell Line
SIGNOR-254327 Homo sapiens
pmid sentence
The activated form of notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. The enzyme accounting for this deubiquitinase activity is eif3f, known so far as a translation initiation factor.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL7R 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254345 Homo sapiens T-lymphocyte
pmid sentence
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254336 Homo sapiens
pmid sentence
Notch signal transduction pathway genes, lfng, hey1, and hes1, are differen-tially regulated by bmp-2 and tgf-beta.
Publications: 1 Organism: Homo Sapiens
+ FOXO3down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.382
Identifier Residue Sequence Organism Cell Line
SIGNOR-254320 Mus musculus Satellite Cell
pmid sentence
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.
Publications: 1 Organism: Mus Musculus
+ DLL3up-regulates activity img/direct-activation.png binding NOTCH 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-254316 Homo sapiens B-lymphocyte
pmid sentence
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate.
Publications: 1 Organism: Homo Sapiens
+ KPNA6up-regulates img/direct-activation.png relocalization NOTCH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254332 Homo sapiens
pmid sentence
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7. importins alpha3, alpha4 (and to a lesser extent, alpha7) mediate nuclear import of nicd and thus are directly involved in notch signaling.
Publications: 1 Organism: Homo Sapiens
+ ADAM17up-regulates activity img/direct-activation.png cleavage NOTCH 0.729
Identifier Residue Sequence Organism Cell Line
SIGNOR-254334 Homo sapiens HeLa Cell
pmid sentence
... here we show that an additional processing event occurs in the extracellular part of the receptor, preceding cleavage by the gamma-secretase-like activity. Purification of the activity accounting for this cleavage in vitro shows that it is due to tace (tnfalpha-converting enzyme), a member of the adam (a disintegrin and metalloprotease domain) family of metalloproteases.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png PAX7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254343 Homo sapiens
pmid sentence
We provide evidence that notch and deltex may act on e47 by inhibiting signaling through ras because (i) full e47 activity was found to be dependent on ras and (ii) both notch and deltex inhibited gal4-jun, a hybrid transcription factor whose activity is dependent on signaling from ras to sapk/jnk.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Satellite Cell
Pathways:Acute Myeloid Leukemia
+ SIAH1up-regulates img/direct-activation.png relocalization NOTCH 0.263
Identifier Residue Sequence Organism Cell Line
SIGNOR-254330 Homo sapiens
pmid sentence
The overexpression of siah1 causes the re-localization of notch from the cell surface to the cytoplasm and to the nucleus, which is indicative of notch activation
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation JAG1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254348 Homo sapiens
pmid sentence
Contact with skip is required for biological activity of notchic. A mutation in the fourth ankyrin repeat that abolished notch signal transduction did not affect interaction with cbf1 but abolished interaction with skip.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEY1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254341 Mus musculus C2C12 Cell, Osteoblast
pmid sentence
Deltex, meltrin beta, ifi-202, and ifi-204 were also upregulated by notchic in the 2b4.11 t cell hybridoma, whereas ifi-d3 was expressed constitutively at relatively high levels and slightly upregulated by notchic, and pre-talfa was not expressed. Deltex, meltrin beta, pre-talfa, ifi-202, and ifi-204 were upregulated by notchic expression in the akr1 dp thymoma cell line, whereas ifi-d3 was not expressed
Publications: 1 Organism: Mus Musculus
+ FOXOdown-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254306 Mus musculus
pmid sentence
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ EGFL7down-regulates activity img/direct_inhibition.png binding NOTCH 0.487
Identifier Residue Sequence Organism Cell Line
SIGNOR-266860 Mus musculus Neural Stem Cell
pmid sentence
Here we have identified transmembrane receptors of the Notch family as EGFL7-binding molecules. Secreted EGFL7 binds to a region in Notch involved in ligand-mediated receptor activation, thus acting as an antagonist of Notch signalling. Expression of EGFL7 in neural stem cells (NSCs) in vitro decreased Notch-specific signalling and consequently, reduced proliferation and self-renewal of NSCs.
Publications: 1 Organism: Mus Musculus
+ HIF1ANdown-regulates img/direct_inhibition.png hydroxylation NOTCH 0.566
Identifier Residue Sequence Organism Cell Line
SIGNOR-254324 Homo sapiens
pmid sentence
We show that fih-1 hydroxylates notch icd at two residues (n(1945) and n(2012)) that are critical for the function of notch icd as a transactivator within cells and during neurogenesis and myogenesis in vivo. Fih-1 negatively regulates notch activity and accelerates myogenic differentiation.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates img/direct-activation.png binding MAML2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254347 Homo sapiens
pmid sentence
Other than a role in t-cell development, the hox genes may be involved in alternative notchregulated processes in hematopoietic stem cells. Notch signaling is clearly important for self-renewal of hematopoietic progenitors (reviewed by radkte et al. 57). Interestingly, hoxa5, a9 and a10 were found to be part of the stem cell profile'
Publications: 1 Organism: Homo Sapiens
+ SDC3up-regulates activity img/direct-activation.png binding NOTCH 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-254329 Mus musculus Satellite Cell
pmid sentence
Furthermore, we show that Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-€“converting enzyme (TACE) and signal transduction. Together, our data support the conclusion that Syndecan-3 and Notch cooperate in regulating homeostasis of the satellite cell population and myofiber size.
Publications: 1 Organism: Mus Musculus
+ CCNCdown-regulates img/direct_inhibition.png phosphorylation NOTCH 0.459
Identifier Residue Sequence Organism Cell Line
SIGNOR-254309 Homo sapiens
pmid sentence
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo.
Publications: 1 Organism: Homo Sapiens
+ FBXW7down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NOTCH 0.631
Identifier Residue Sequence Organism Cell Line
SIGNOR-254310 Homo sapiens
pmid sentence
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ SMAD3up-regulates img/direct-activation.png binding NOTCH 0.718
Identifier Residue Sequence Organism Cell Line
SIGNOR-254325 Homo sapiens
pmid sentence
Nicd and smad3 were shown to interact directly, both in vitro and in cells, in a ligand-dependent manner, and smad3 could be recruited to csl-binding sites on dna in the presence of csl and nicd
Publications: 1 Organism: Homo Sapiens
+ DLL1up-regulates activity img/direct-activation.png binding NOTCH 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-254315 Homo sapiens B-lymphocyte
pmid sentence
Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common mechanism. Upon ligand binding Notch receptors are proteoliticaly cleaved, the intracellular domain of Notch (NICD) is released and translocated to the nucleus, where it activates target genes. In mammals, four receptors and five ligands have been described. Delta-1, Delta-3 and Delta-4 are homologues to Drosophila Delta and Jagged-1 and Jagged-2 to Drosophila Serrate.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEYL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254339 Homo sapiens
pmid sentence
The intracellular part of the notch receptor is cleaved off and translocates to the nucleus, where it binds to the transcription factor rbp-j.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ MAML1up-regulates img/direct-activation.png binding NOTCH 0.921
Identifier Residue Sequence Organism Cell Line
SIGNOR-269934 Homo sapiens
pmid sentence
Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes4
Publications: 1 Organism: Homo Sapiens
+ gamma-secretaseup-regulates img/direct-activation.png cleavage NOTCH 0.665
Identifier Residue Sequence Organism Cell Line
SIGNOR-255372
pmid sentence
Receptor–ligand engagement triggers a second NECD cleavage (S2 cleavage) by a metalloproteinase ADAM (known as Kuzbanian in Drosophila melanogaster), which in turn facilitates a further crucial signaling cleavage within the Notch transmembrane domain by a γ-secretase complex that contains Presenilin (S3 cleavage)
Publications: 1
+ NOTCHup-regulates img/indirect-activation.png BMPR1A/1B/2 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-254335 Homo sapiens
pmid sentence
Similar synergy is found in notch and bmp crosstalk: activating notch signaling enhanced bmp-induced alp activity and formation of calcified nodules in vitro.
Publications: 1 Organism: Homo Sapiens
+ CDK8down-regulates img/direct_inhibition.png phosphorylation NOTCH 0.534
Identifier Residue Sequence Organism Cell Line
SIGNOR-254312 Homo sapiens
pmid sentence
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo.
Publications: 1 Organism: Homo Sapiens
+ KAT2Bup-regulates img/direct-activation.png acetylation NOTCH 0.585
Identifier Residue Sequence Organism Cell Line
SIGNOR-254311 Homo sapiens
pmid sentence
In earlier studies, we demonstrated that maml1 enhanced p300 acetyltransferase activity, which increased the acetylation of notch by p300.Acetylation controls notch stability and function in t-cell leukemia.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates img/direct-activation.png binding SNW1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254337 Homo sapiens
pmid sentence
Notch signal transduction pathway genes, lfng, hey1, and hes1, are differen-tially regulated by bmp-2 and tgf-beta.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ CKM complexdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-273153 Homo sapiens
pmid sentence
Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation ADAM19 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254340 Homo sapiens
pmid sentence
Interestingly, in absence of delta signal, both hes-1 and tcfl5 decreased, and further decreased by incubation with dapt. (figure 4). This pharmacological approach therefore provides additional evidence that tcfl5, similar to hes1, is a true notch target gene.
Publications: 1 Organism: Homo Sapiens
+ KPNA3up-regulates img/direct-activation.png relocalization NOTCH 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-254321 Homo sapiens
pmid sentence
Nicd binds via one of its four potential nuclear localization signals to importins alfa3, alfa4, and alfa7.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254349 Homo sapiens
pmid sentence
Moreover, as determined by using coimmunoprecipitation assays, each maml protein was found to be capable of forming a multiprotein complex with the intracellular domain of each notch receptor (icn1 to -4) and csl in vivo
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ DTX1up-regulates activity img/direct-activation.png ubiquitination NOTCH 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-254317 Drosophila melanogaster
pmid sentence
The expression of dx, which physically interacts with notch, favors a mono-ubiquitinated state of the receptor, which leads to a ligand-independent intracellular activation of notch
Publications: 1 Organism: Drosophila Melanogaster
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254344 Homo sapiens T-lymphocyte
pmid sentence
Addition of jag-1 peptide induced ikkalpha mediated nf-kappab activation, as well as increased ppargamma expression.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ CNTN6up-regulates img/direct-activation.png relocalization NOTCH 0.571
Identifier Residue Sequence Organism Cell Line
SIGNOR-254318 Homo sapiens Neuron
pmid sentence
Here, we establish that nb-3, a member of the f3/contactin family, acts as a novel notch ligand to participate in oligodendrocyte generation. Nb-3 triggers nuclear translocation of the notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via deltex1.
Publications: 1 Organism: Homo Sapiens
+ gamma-secretaseup-regulates activity img/direct-activation.png cleavage NOTCH 0.665
Identifier Residue Sequence Organism Cell Line
SIGNOR-254328 Homo sapiens
pmid sentence
The membrane-bound Notch segment that results from this cleavage, known as Notch Intracellular Truncation domain (NEXT), is a -secretase substrate (Kopan and Ilagan, 2009). -Secretase performs the subsequent cleavage at S3 (De Strooper et al., 1999), releasing Notch intracellular domain (NICD) from the membrane and allowing for signal transduction through binding with the CBL-1, Su(H), Lag-1 (CSL; Schroeter et al., 1998; Struhl and Adachi, 1998) family of DNA binding proteins.
Publications: 1 Organism: Homo Sapiens
+ NOTCHup-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261534 Homo sapiens
pmid sentence
Notch signaling is initiated by the interaction of Notch ligands and receptors on adjacent cells, which further triggers two proteolytic cleavage events. The first cleavage releases a functional extracellular domain (NECD); the second cleavage, mediated by γ-secretase, releases the intracellular domain (NICD) into the cytoplasm. The NICD then translocates to the nucleus, binds to the transcription factor CBF/Su (H)/LAG-2 (CSL), and recruits Mastermind-like protein 1 and p300/CBP to induce transcription of Notch target genes, including Hes1, p21, Akt, cyclin D1, and mTOR
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ MAML2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH 0.858
Identifier Residue Sequence Organism Cell Line
SIGNOR-254307 Homo sapiens
pmid sentence
We recently cloned a mammalian homologue of the mastermind gene of drosophila melanogaster, maml1 (mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for notch receptors.
Publications: 1 Organism: Homo Sapiens
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