Relation Results

Summary

Name SMURF
Primary ID SIGNOR-PF29
Type protein family
Formed by SMURF1, SMURF2
Relations 13
Pathways TGF-beta Signaling

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Type: Score: Layout: SPV 
0.20.20.8950.20.20.20.20.20.20.20.20.20.2SMURFSMAD9SMAD5SMAD7TGFBR2SMAD2SMAD4TGFBR1SMAD1SKILBMPR2SMAD6BMPR1A

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Relations
Regulator
Mechanism
target
score ℹ
+ SMURFdown-regulates img/direct_inhibition.png ubiquitination SMAD9 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270211 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
+ SMURFdown-regulates img/direct_inhibition.png ubiquitination SMAD5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270213 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
+ SMAD7up-regulates activity img/direct-activation.png relocalization SMURF 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-253258 Homo sapiens
pmid sentence
Smad7 also recruits the HECT type of E3 ubiquitin ligases, Smurf1 and Smurf2. It binds to Smurfs in the nucleus and translocates into the cytoplasm in response to TGF-_ and recruits the ubiquitin ligases to the activated type I receptor ALK5/T_RI, leading to the degradation of the receptor through the proteasomal pathway.
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination TGFBR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253265 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps.
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253263 Homo sapiens
pmid sentence
The ability of smurf2 to promote smad2 destruction required the hect catalytic activity of smurf2 and depended on the proteasome-dependent pathway.
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
Pathways:TGF-beta Signaling
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination SMAD4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253259 Homo sapiens HEK-293T Cell
pmid sentence
Smurfs, which otherwise cannot directly bind to smad4, mediated poly-ubiquitination of smad4 in the presence of smad6 or smad7. Smad signaling is negatively regulated by inhibitory (i) smads and ubiquitin-mediated processes.
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination TGFBR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253264 Homo sapiens
pmid sentence
Recruitment of ww and hect domain e3-ubiquitin ligases smurf1 and 2 to induce type i receptor ubiquitination and subsequent receptor degradation
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates img/direct_inhibition.png ubiquitination SMAD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270214 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination SKIL 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253262 Homo sapiens
pmid sentence
Tgf-beta also induces the association of smurf2 with the transcriptional co-repressor snon and we show that smad2 can function to mediate this interaction. This allows smurf2 hect domain to target snon for ubiquitin-mediated degradation by the proteasome.
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293T Cell, Mv1Lu Cell
Pathways:TGF-beta Signaling
+ SMURFdown-regulates img/direct_inhibition.png ubiquitination BMPR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270215 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps.
Publications: 1 Organism: Homo Sapiens
+ SMURFdown-regulates activity img/direct_inhibition.png relocalization SMAD6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253261 Homo sapiens
pmid sentence
Smurf1, with its WW domain, specifically binds to the PY motif of Smad6 and transports Smad6 into the cytoplasm.
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates activity img/direct_inhibition.png ubiquitination SMAD7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253260 Homo sapiens
pmid sentence
Smad ubiquitin regulatory factor 1 (Smurf1), a HECT type E3 ubiquitin ligase, interacts with inhibitory Smad7 and induces translocation of Smad7 to the cytoplasm
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ SMURFdown-regulates img/direct_inhibition.png ubiquitination BMPR1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270212 Homo sapiens
pmid sentence
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps
Publications: 1 Organism: Homo Sapiens
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