Relation Results

Summary

Name FOXO
Primary ID SIGNOR-PF27
Type protein family
Formed by FOXO1, FOXO3, FOXO4, FOXO6
Relations 179
Pathways Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, FLT3-ITD in AML, FLT3-ITD signaling, Myofiber: BMP, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism

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Type: Score: Layout: SPV 
0.9080.9080.6730.7030.5250.6380.6970.7560.3960.4110.7870.5150.4470.20.710.5820.3940.4740.520.3980.5090.5360.4160.5540.6790.5120.20.7030.20.20.20.5670.9090.70.20.5280.70.4380.20.70.7020.4070.20.20.70.4010.20.20.20.20.20.710.20.20.20.20.3750.20.20.20.70.3090.20.20.70.20.4910.2AKT1FOXOAKTSTK4JNKCDK1CDK2AKT3AKT2PIM1PPP2CASGK1SGK2SGK3PKN1MAPK1MAPK3CSNK1A1CSNK1G1DYRK1AAMPKPRKAA1IKK-complexIKBKECHUKIKBKBMAPK14RALAMAPK8CDKN1BSETD2G6PC1PPARGC1ASIRT1Muscle_atrophyCDKN2DCREB1AdipogenesisDUSP6MYOD1Cell_death14-3-3TSC22D3NOTCH3IDH1ApoptosisPIMPPARGFBXO32TRIM63BCL2L11CDKN2BERK1/2PCK1FASLGGKNOTCHHDAC1GbetaIGFBP1ProliferationTEAD1RBL2CITED2MetabolismNOTCH1INSG6P

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT1down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252853 Ser197 APRRRAAsMDSSSKL Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252856 Ser256 SPRRRAAsMDNNSKF in vitro CV-1 Cell
pmid sentence
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252854 Ser262 TFRPRSSsNASSVST Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252860 Ser319 TFRPRTSsNASTISG Homo sapiens
pmid sentence
The transcription factor, forkhead in rhabdomyosarcoma (fkhr), is phosphorylated at three amino acid residues (thr-24, ser-256 and ser-319) by protein kinase b (pkb)alpha.Fkhr (forkhead in rhabdomyosarcoma), afx (all1 fused gene from chromosome x) and fkhrl1 (fkhr-like 1) are phosphorylated directly by pkb in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus
Identifier Residue Sequence Organism Cell Line
SIGNOR-252857 Thr24 LPRPRSCtWPLPRPE in vitro CV-1 Cell
pmid sentence
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252855 Thr32 QSRPRSCtWPLPRPE Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252843 Homo sapiens
pmid sentence
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252852 Mus musculus MEF Cell
pmid sentence
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export ofFoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252847 Homo sapiens
pmid sentence
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252859 Homo sapiens
pmid sentence
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:FLT3-ITD signaling
+ AKT1down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252861 Ser197 APRRRAAsMDSSSKL Mus musculus NIH-3T3-A14 Cell
pmid sentence
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252849 Ser253 APRRRAVsMDNSNKY Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252862 Ser262 TFRPRSSsNASSVST Mus musculus
pmid sentence
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252850 Ser315 DFRSRTNsNASTVSG Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252848 Thr32 QSRPRSCtWPLQRPE Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252841 Homo sapiens
pmid sentence
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252851 Mus musculus MEF Cell
pmid sentence
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export ofFoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation.
Publications: 7 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling
+ AKTdown-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252838 Ser197 APRRRAAsMDSSSKL Mus musculus NIH-3T3-A14 Cell
pmid sentence
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252826 Ser253 APRRRAVsMDNSNKY Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252839 Ser262 TFRPRSSsNASSVST Mus musculus
pmid sentence
Here we show that protein kinase B phosphorylates AFX, a human orthologue of daf -16 (refs 5, 6, 9), both in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252827 Ser315 DFRSRTNsNASTVSG Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252825 Thr32 QSRPRSCtWPLQRPE Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252836 Mus musculus MEF Cell
pmid sentence
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ AKTdown-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252828 Ser197 APRRRAAsMDSSSKL Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252831 Ser256 SPRRRAAsMDNNSKF in vitro CV-1 Cell
pmid sentence
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252829 Ser262 TFRPRSSsNASSVST Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252835 Ser319 TFRPRTSsNASTISG Homo sapiens
pmid sentence
The transcription factor, forkhead in rhabdomyosarcoma (fkhr), is phosphorylated at three amino acid residues (thr-24, ser-256 and ser-319) by protein kinase b (pkb)alpha.Fkhr (forkhead in rhabdomyosarcoma), afx (all1 fused gene from chromosome x) and fkhrl1 (fkhr-like 1) are phosphorylated directly by pkb in cells, preventing them from stimulating gene transcription and leading to their exit from the nucleus
Identifier Residue Sequence Organism Cell Line
SIGNOR-252832 Thr24 LPRPRSCtWPLPRPE in vitro CV-1 Cell
pmid sentence
Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors induces phosphorylation, nuclear export, and transcriptional inactivation of FKHR1, a member of the FKHR subclass of the forkhead family of transcription factors. Protein kinase B (PKB)/Akt, a key mediator of PI3 kinase signal transduction, phosphorylated recombinant FKHR1 in vitro at threonine-24 and serine-253. Mutants FKHR1(T24A), FKHR1(S253A), and FKHR1(T24A/S253A) were resistant to both PKB/Akt-mediated phosphorylation and PI3 kinase-stimulated nuclear export.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252830 Thr32 QSRPRSCtWPLPRPE Homo sapiens
pmid sentence
Foxo4 transcription factor, also referred to afx, contains three putative phosphorylation motif sites for protein kinase b (pkb), thr32, ser197, and ser262, and it is proposed that phosphorylated foxo4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-252837 Mus musculus MEF Cell
pmid sentence
Akt1/PKBalpha was found to be the major regulator of phosphorylation and nuclear export of FoxO1, whose presence in the nucleus strongly attenuates adipocyte differentiation
Identifier Residue Sequence Organism Cell Line
SIGNOR-252824 Homo sapiens
pmid sentence
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252820 Homo sapiens
pmid sentence
Akt inactivates protein degradation by phosphorylating and thus repressing the transcription factors of the foxo family, and stimulates protein synthesis via the mammalian target of rapamycin (mtor) and glycogen synthase kinase 3b (gsk3b).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252834 Homo sapiens
pmid sentence
The phosphorylation of the two remaining akt-dependent sites inhibits foxo6 transcriptional activity
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ STK4up-regulates img/direct-activation.png phosphorylation FOXO 0.673
Identifier Residue Sequence Organism Cell Line
SIGNOR-253001 Ser209 SSAGWKNsIRHNLSL Homo sapiens
pmid sentence
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253000 Ser209 SSAGWKNsIRHNLSL Homo sapiens T-lymphocyte
pmid sentence
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252998 Ser212 SSAGWKNsIRHNLSL Homo sapiens T-lymphocyte
pmid sentence
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252999 Ser212 SSAGWKNsIRHNLSL Homo sapiens
pmid sentence
Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253002 Homo sapiens
pmid sentence
The other major signaling modules that directly regulate the activity of the foxo factors include the stress-activated jun-n-terminal kinase (jnk), the mammalian ortholog of the ste20-like protein kinase (mst1), and the deacetylase sirt1
Publications: 5 Organism: Homo Sapiens
Tissue: Skin
+ JNKup-regulates img/direct-activation.png phosphorylation FOXO 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-252953 Ser230 PEGATPTsPVGHFAK Homo sapiens Melanoma Cell
pmid sentence
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252954 Thr227 PAPPEGAtPTSPVGH Homo sapiens Melanoma Cell
pmid sentence
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252955 Thr451 PIPKALGtPVLTPPT Homo sapiens Melanoma Cell
pmid sentence
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451).
Identifier Residue Sequence Organism Cell Line
SIGNOR-252956 Thr455 ALGTPVLtPPTEAAS Homo sapiens Melanoma Cell
pmid sentence
Braf(v600e) signaling through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase resulted in increased reactive oxygen species levels and c-jun nh(2) terminal kinase-mediated activation of foxo4 via its phosphorylation on thr(223), ser(226), thr(447), and thr(451).
Publications: 4 Organism: Homo Sapiens
Tissue: Skin
Pathways:FLT3-ITD signaling
+ CDK1down-regulates img/direct_inhibition.png phosphorylation FOXO 0.525
Identifier Residue Sequence Organism Cell Line
SIGNOR-252890 Ser249 EGGKSGKsPRRRAAS Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Overexpression of cdk1 inhibits the transcriptional activity of foxo1 in pca cells through s249 phosphorylation on foxo1.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ CDK2down-regulates img/direct_inhibition.png phosphorylation FOXO 0.638
Identifier Residue Sequence Organism Cell Line
SIGNOR-252892 Ser249 EGGKSGKsPRRRAAS Homo sapiens
pmid sentence
Cdk2 specifically phosphorylated foxo1 at serine-249 (ser249) in vitro and in vivo. Phosphorylation of ser249 resulted in cytoplasmic localization and inhibition of foxo1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252891 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity
Publications: 2 Organism: Homo Sapiens
+ AKT3down-regulates img/direct_inhibition.png phosphorylation FOXO 0.697
Identifier Residue Sequence Organism Cell Line
SIGNOR-252877 Ser253 APRRRAVsMDNSNKY Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252878 Ser315 DFRSRTNsNASTVSG Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252879 Thr32 QSRPRSCtWPLQRPE Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Publications: 3 Organism: Homo Sapiens
+ AKT2down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-252867 Ser253 APRRRAVsMDNSNKY Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252871 Ser256 SPRRRAAsMDNNSKF Homo sapiens
pmid sentence
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252868 Ser315 DFRSRTNsNASTVSG Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252872 Thr24 LPRPRSCtWPLPRPE Homo sapiens
pmid sentence
Our results demonstrate that pkb/akt directly phosphorylates fkhr1, a member of the closely related fkhr subclass of the forkhead family of transcription factors, on at least two residues (threonine-24 and serine-253). These results indicate that phosphorylation by pkbyakt negatively regulates fkhr1 by promoting export from the nucleus.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252870 Thr32 QSRPRSCtWPLPRPE Homo sapiens
pmid sentence
FOXO4 transcription factor, also referred to AFX, contains three putative phosphorylation motif sites for protein kinase B (PKB), Thr32, Ser197, and Ser262, and it is proposed that phosphorylated FOXO4 stays in the cytosol and is imported to the nucleus through dephosphorylation to induce target gene expression.[...]These results indicate that phosphorylation at Thr32 and Ser197 is indispensable, whereas that at Ser262 is not critical, for regulation of the nuclear localization and transcriptional activity of FOXO4
Identifier Residue Sequence Organism Cell Line
SIGNOR-252873 Thr32 QSRPRSCtWPLPRPE Mus musculus NIH-3T3 Cell
pmid sentence
Phosphorylation of AFX by PKB occurs in the nucleus. Phosphorylation of S193 reduces the rate of nuclear import. PKB-mediated phosphorylation of AFX, therefore, attenuates the import of the transcription factor, which shifts the localization of the protein from the nucleus to the cytoplasm and results in the inhibition of AFX transcriptional activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252869 Thr32 QSRPRSCtWPLQRPE Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14-3-3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252866 Homo sapiens
pmid sentence
Akt phosphorylates members of the foxo factors (forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localisation. In particular, akt phosphorylates foxo1 on thr24, ser256 and ser319. Foxo 3alfa and foxo4 are phosphorylated on equivalent sites. In addition, phosphorylation of afx by protein kinase b inhibits its transcriptional activity.
Publications: 8 Organism: Homo Sapiens, Mus Musculus
+ PIM1down-regulates img/direct_inhibition.png phosphorylation FOXO 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-252966 Ser253 APRRRAVsMDNSNKY Homo sapiens
pmid sentence
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252967 Thr32 QSRPRSCtWPLQRPE Homo sapiens
pmid sentence
Pim1s expression induced the phosphorylation of foxo3a (fig. 5a and b) and inactivated its transcriptional activity (fig. 5c). A previous report showed that phosphorylation at t32, s253, and s315 residues in foxo3a induced 14-3-3 binding, nuclear export, and proteasomemediated degradation (42).
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ PPP2CAup-regulates img/direct-activation.png dephosphorylation FOXO 0.411
Identifier Residue Sequence Organism Cell Line
SIGNOR-252971 Ser253 APRRRAVsMDNSNKY Homo sapiens
pmid sentence
Pp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252973 Ser253 APRRRAVsMDNSNKY Homo sapiens
pmid sentence
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252974 Thr32 QSRPRSCtWPLQRPE Homo sapiens
pmid sentence
Protein phosphatase 2a reactivates foxo3a through a dynamic interplay with 14-3-3 and aktpp2a-mediated dephosphorylation of t32/s253 is required for dissociation of 14-3-3, nuclear translocation, and transcriptional activation of foxo3a.
Publications: 3 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ AKT1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252844 Ser253 APRRRAVsMDNSNKY
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252845 Ser315 DFRSRTNsNASTVSG
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252846 Thr32 QSRPRSCtWPLQRPE
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252858 Homo sapiens
pmid sentence
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs
Publications: 4 Organism: , Homo Sapiens
Pathways:FLT3-ITD signaling
+ SGK1down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.787
Identifier Residue Sequence Organism Cell Line
SIGNOR-252987 Ser253 APRRRAVsMDNSNKY Homo sapiens HEK-293 Cell
pmid sentence
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252989 Ser315 DFRSRTNsNASTVSG Homo sapiens HEK-293 Cell
pmid sentence
We show here that sgk1, like akt, promotes cell survival and that it does so in part by phosphorylating and inactivating fkhrl1. However, sgk and akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on fkhrl1. While both kinases can phosphorylate thr-32, sgk displays a marked preference for ser-315 whereas akt favors ser-253.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252988 Thr32 QSRPRSCtWPLQRPE Homo sapiens HEK-293 Cell
pmid sentence
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis.
Publications: 3 Organism: Homo Sapiens
+ AKT3down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.697
Identifier Residue Sequence Organism Cell Line
SIGNOR-252874 Ser253 APRRRAVsMDNSNKY
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252875 Ser315 DFRSRTNsNASTVSG
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252876 Thr32 QSRPRSCtWPLQRPE
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Publications: 3
+ SGK2down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.515
Identifier Residue Sequence Organism Cell Line
SIGNOR-252990 Ser253 APRRRAVsMDNSNKY Homo sapiens HEK-293 Cell
pmid sentence
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252991 Thr32 QSRPRSCtWPLQRPE Homo sapiens HEK-293 Cell
pmid sentence
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis.
Publications: 2 Organism: Homo Sapiens
+ SGK3down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.447
Identifier Residue Sequence Organism Cell Line
SIGNOR-252992 Ser253 APRRRAVsMDNSNKY Homo sapiens HEK-293 Cell
pmid sentence
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)|However, SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. The efficient phosphorylation of these three sites on FKHRL1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL1-dependent transcription, thereby preventing FKHRL1 from inducing cell cycle arrest and apoptosis.
Publications: 1 Organism: Homo Sapiens
+ AKTdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-252821 Ser253 APRRRAVsMDNSNKY Homo sapiens
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252822 Ser315 DFRSRTNsNASTVSG Homo sapiens
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252823 Thr32 QSRPRSCtWPLQRPE Homo sapiens
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252833 Homo sapiens
pmid sentence
Phosphorylation of FoxOs by Akt inhibits transcriptional functions of FoxOs and contributes to cell survival, growth and proliferation.The PI3K/Akt signaling regulates cell proliferation and survival in part by phosphorylating FoxOs to promote their interaction with 14-3-3 protein that results in nuclear exclusion and eventual ubiquitin proteasome pathway (UPP)-dependent degradation of FoxOs
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ AKT2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-252863 Ser253 APRRRAVsMDNSNKY
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252864 Ser315 DFRSRTNsNASTVSG
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252865 Thr32 QSRPRSCtWPLQRPE
pmid sentence
AKT phosphorylates FOXO3a at three conserved sites (Thr32, Ser253 and Ser315), therefore creating binding sites for the 14-3-3 chaperone proteins and leading to the active export of FOXO3a to the cytoplasm where it is targeted for proteasomal degradation.
Publications: 3
+ PKN1down-regulates img/direct_inhibition.png phosphorylation FOXO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252968 Ser256 SPRRRAAsMDNNSKF Homo sapiens Breast Cancer Cell
pmid sentence
Furthermore, estrogen induced phosphorylation and perinuclear localization of the cell survival forkhead transcription factor fkhr in the cytoplasm in a pak1-dependent manner. In addition, pak1 directly interacted with fkhr and phosphorylated it. The noticed phosphorylation-dependent exclusion of fkhr from the nucleus impaired the ability of fkhr to activate its target fas ligand promoter containing the fkhr binding motif (fre) in cells treated with estrogen or expressing catalytically active pak1.
Publications: 1 Organism: Homo Sapiens
+ MAPK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.71
Identifier Residue Sequence Organism Cell Line
SIGNOR-252957 Ser294 QLSKWPGsPTSRSSD Homo sapiens
pmid sentence
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252958 Ser344 QDDDAPLsPMLYSSS Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252959 Ser425 TKGSGLGsPTSSFNS Homo sapiens HEK-293 Cell
pmid sentence
Here, we show that erk downregulates forkhead box o 3a (foxo3a) by directly interacting with and phosphorylating foxo3a at ser 294, ser 344 and ser 425, which consequently promotes cell proliferation and tumorigenesisMDM2 is required for ERk-mediated FOXO3a degradation.
Publications: 3 Organism: Homo Sapiens
+ MAPK3down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.582
Identifier Residue Sequence Organism Cell Line
SIGNOR-252961 Ser294 QLSKWPGsPTSRSSD Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-252962 Ser344 QDDDAPLsPMLYSSS Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-252963 Ser425 TKGSGLGsPTSSFNS Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Publications: 3 Organism: Homo Sapiens
+ CSNK1A1down-regulates img/direct_inhibition.png phosphorylation FOXO 0.394
Identifier Residue Sequence Organism Cell Line
SIGNOR-252899 Ser318 SRTNSNAsTVSGRLS Homo sapiens
pmid sentence
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export
Identifier Residue Sequence Organism Cell Line
SIGNOR-252900 Ser321 NSNASTVsGRLSPIM Homo sapiens
pmid sentence
Casein kinase (ck) 1 mediates the hierarchical phosphorylation of foxo3a at s318 and s321, which like foxo1 (rena et al., 2002 blue right-pointing triangle, 2004 blue right-pointing triangle), is probably to enhance its rate of nuclear export
Identifier Residue Sequence Organism Cell Line
SIGNOR-252898 Homo sapiens
pmid sentence
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity.
Publications: 3 Organism: Homo Sapiens
+ CSNK1G1down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.474
Identifier Residue Sequence Organism Cell Line
SIGNOR-252901 Ser322 PRTSSNAsTISGRLS in vitro
pmid sentence
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR
Identifier Residue Sequence Organism Cell Line
SIGNOR-252902 Ser325 SSNASTIsGRLSPIM in vitro
pmid sentence
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR
Publications: 2 Organism: In Vitro
+ DYRK1Adown-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.52
Identifier Residue Sequence Organism Cell Line
SIGNOR-252909 Ser329 STISGRLsPIMTEQD Homo sapiens
pmid sentence
The kinase dyrk1a phosphorylates the transcription factor fkhr at ser329 in vitro, a novel in vivo phosphorylation siteser(329) phosphorylation also decreases the ability of fkhr to stimulate gene transactivation and reduces the proportion of fkhr present in the nucleus
Identifier Residue Sequence Organism Cell Line
SIGNOR-252906 Ser330 RLSPIMAsTELDEVQ Homo sapiens
pmid sentence
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition.
Publications: 2 Organism: Homo Sapiens
+ DYRK1Adown-regulates img/direct_inhibition.png phosphorylation FOXO 0.52
Identifier Residue Sequence Organism Cell Line
SIGNOR-252907 Ser330 RLSPIMAsTELDEVQ Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity phosphorylation of foxos by akt, ikk, erk, ck1, cdk2, and dyrk1a universally leads to foxo's inhibition.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252905 Homo sapiens
pmid sentence
Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity
Publications: 2 Organism: Homo Sapiens
+ AMPKup-regulates activity img/direct-activation.png phosphorylation FOXO 0.398
Identifier Residue Sequence Organism Cell Line
SIGNOR-252880 Ser399 DNITLPPsQPSPTGG Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252881 Ser413 GLMQRSSsFPYTTKG Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252882 Ser555 RALSNSVsNMGLSES Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252883 Ser588 QTLSDSLsGSSLYST Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252884 Ser626 SLECDMEsIIRSELM Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252885 Thr179 SSPDKRLtLSQIYEW Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252889 Homo sapiens
pmid sentence
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt.
Publications: 7 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new
+ PRKAA1up-regulates activity img/direct-activation.png phosphorylation FOXO 0.509
Identifier Residue Sequence Organism Cell Line
SIGNOR-252975 Ser399 DNITLPPsQPSPTGG Homo sapiens
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252976 Ser413 GLMQRSSsFPYTTKG Homo sapiens
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252977 Ser555 RALSNSVsNMGLSES Homo sapiens
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252978 Ser588 QTLSDSLsGSSLYST Homo sapiens
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252979 Ser626 SLECDMEsIIRSELM Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252980 Thr179 SSPDKRLtLSQIYEW Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation by AMPK leads to the activtion of FOXO3 transcriptional activity without affecting FOXO3 subcellular localization.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252983 Caenorhabditis elegans
pmid sentence
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt.
Publications: 7 Organism: Homo Sapiens, Caenorhabditis Elegans
+ IKK-complexdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.536
Identifier Residue Sequence Organism Cell Line
SIGNOR-252950 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell
pmid sentence
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKK-complexdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.536
Identifier Residue Sequence Organism Cell Line
SIGNOR-252951 Ser644 GLDFNFDsLISTQNV Homo sapiens
pmid sentence
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ IKBKEdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-252949 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell, Lung Cancer Cell
pmid sentence
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation.
Publications: 1 Organism: Homo Sapiens
+ CHUKdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.554
Identifier Residue Sequence Organism Cell Line
SIGNOR-252893 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell
pmid sentence
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a. The tnf treatment of ht-29 cells increased ikk-dependent foxo3 ser644 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ IKBKBdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.679
Identifier Residue Sequence Organism Cell Line
SIGNOR-252947 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway
Identifier Residue Sequence Organism Cell Line
SIGNOR-252948 Ser644 GLDFNFDsLISTQNV Homo sapiens Breast Cancer Cell
pmid sentence
Ikkbeta phosphorylates foxo3a at ser644. Ikappab kinase (ikk) physically interacts with, phosphorylates, and inhibits foxo3a independent of akt and causes proteolysis of foxo3a via the ub-dependent proteasome pathway
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ MAPK14up-regulates img/direct-activation.png phosphorylation FOXO 0.512
Identifier Residue Sequence Organism Cell Line
SIGNOR-252960 Ser7 sPAPLSPL Homo sapiens Breast Cancer Cell
pmid sentence
Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ RALAup-regulates activity img/direct-activation.png phosphorylation FOXO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252984 Thr451 PIPKALGtPVLTPPT Mus musculus
pmid sentence
We conclude that Ral-mediated phosphorylation of threonines 447 and 451 is required for proper activity of AFX-WT.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252985 Thr455 ALGTPVLtPPTEAAS Mus musculus NIH-3T3 Cell
pmid sentence
We conclude that Ral-mediated phosphorylation of threonines 447 and 451 is required for proper activity of AFX-WT.
Publications: 2 Organism: Mus Musculus
+ MAPK8up-regulates img/direct-activation.png phosphorylation FOXO 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-252964 Thr451 PIPKALGtPVLTPPT Homo sapiens
pmid sentence
Upon treatment of cells with h2o2, the small gtpase ral is activated and this results in a jnk-dependent phosphorylation of foxo4 on threonine 447 and threonine 451. This ral-mediated, jnk-dependent phosphorylation is involved in the nuclear translocation and transcriptional activation of foxo4 after h2o2 treatment.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252965 Thr455 ALGTPVLtPPTEAAS Homo sapiens
pmid sentence
Upon treatment of cells with h2o2, the small gtpase ral is activated and this results in a jnk-dependent phosphorylation of foxo4 on threonine 447 and threonine 451. This ral-mediated, jnk-dependent phosphorylation is involved in the nuclear translocation and transcriptional activation of foxo4 after h2o2 treatment.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ FOXOup-regulates quantity img/direct-activation.png transcriptional regulation CDKN1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252928 Mus musculus
pmid sentence
AFX transcriptionally activates p27kip1, resulting in increased protein levels.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ SETD2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252986 Homo sapiens Breast Cancer Cell
pmid sentence
In response to hypoxia, foxo3a transcript levels accumulate in an hif1-dependent way, resulting in enhanced foxo3a activity.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6PC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252921 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252922 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252920 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252923 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Publications: 4 Organism: Homo Sapiens
+ PPARGC1Adown-regulates img/indirect_inhibition.png FOXO 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-252970 Homo sapiens
pmid sentence
Nuclear pgc-1alpha and foxo3a respond in a reciprocal manner following aicar treatment.
Publications: 1 Organism: Homo Sapiens
+ SIRT1down-regulates activity img/indirect_inhibition.png FOXO 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-252995 Homo sapiens HEK-293 Cell
pmid sentence
Sirt1 inhibited foxo3's ability to induce cell death.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ FOXOup-regulates img/indirect-activation.png Muscle_atrophy 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252932 Mus musculus Skeletal Muscle
pmid sentence
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Publications: 1 Organism: Mus Musculus
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252918 Homo sapiens
pmid sentence
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity
Publications: 1 Organism: Homo Sapiens
+ CREB1down-regulates activity img/direct_inhibition.png binding FOXO 0.528
Identifier Residue Sequence Organism Cell Line
SIGNOR-252894 Homo sapiens
pmid sentence
We provide evidence that the acetyltransferase creb-binding protein (cbp) binds foxo resulting in acetylation of foxo. This acetylation inhibits foxo transcriptional activity
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling, Thyroid Hormone Metabolism
+ FOXOdown-regulates img/indirect_inhibition.png Adipogenesis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252911 Homo sapiens
pmid sentence
Akt1/pkbalpha was found to be the major regulator of phosphorylation and nuclear export offoxo1, whose presence in the nucleus strongly attenuates adipocyte differentiation.
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ DUSP6up-regulates img/direct-activation.png dephosphorylation FOXO 0.438
Identifier Residue Sequence Organism Cell Line
SIGNOR-252903 Homo sapiens
pmid sentence
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase).
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252937 Homo sapiens Myoblast
pmid sentence
Our cell-based assays and in vitro studies reveal a tight codependent partnership between foxo3 and pax3/7 to coordinately recruit rna polymerase ii and form a preinitiation complex (pic) to activate myod transcription in myoblasts.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates img/indirect-activation.png Cell_death 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256644 Homo sapiens HEK-293 Cell
pmid sentence
Sirt1 inhibited foxo3's ability to induce cell death.
Publications: 1 Organism: Homo Sapiens
+ 14-3-3down-regulates img/direct_inhibition.png binding FOXO 0.702
Identifier Residue Sequence Organism Cell Line
SIGNOR-252818 Homo sapiens Breast Cancer Cell, Prostate Gland Cancer Cell, Leukemia Cell, Glioblastoma Cell
pmid sentence
In this study, we demonstrate that akt also regulates the activity of fkhrl1, a member of the forkhead family of transcription factors. In the presence of survival factors, akt phosphorylates fkhrl1, leading to fkhrl1's association with 14-3-3 proteins and fkhrl1's retention in the cytoplasm. Akt-dependent phosphorylation of foxo3a (thr32, ser253, and ser315 for human foxo3) enhances foxo3a/14?3?3 Interaction and promotes foxo3a nuclear export to the cytoplasm, resulting in the repression of foxo3a transcriptional function
Identifier Residue Sequence Organism Cell Line
SIGNOR-252819 Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Progressive increase in akt activation during prostate cancer progression led to increase phosphorylation of foxo3a and binding with 14-3-3, which potentially affected its transcriptional activity in age-specific manner.
Publications: 2 Organism: Homo Sapiens
+ TSC22D3down-regulates activity img/direct_inhibition.png relocalization FOXO 0.407
Identifier Residue Sequence Organism Cell Line
SIGNOR-269854 Homo sapiens HL-60 Cell
pmid sentence
GILZ inhibits FOXO1, FOXO3, and FOXO4 transcriptional activities measured with natural or synthetic FOXO-responsive promoters in HL-60 cells.
Publications: 1 Organism: Homo Sapiens
+ FOXOdown-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252941 Mus musculus
pmid sentence
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.
Publications: 1 Organism: Mus Musculus
+ FOXOup-regulates quantity by expression img/direct-activation.png transcriptional regulation IDH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260088 Homo sapiens
pmid sentence
We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, NPM1_new
+ FOXOup-regulates img/indirect-activation.png Apoptosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252939 Homo sapiens HEK-293 Cell
pmid sentence
Sirt1 inhibited foxo3's ability to induce cell death.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new
+ PIMdown-regulates img/direct_inhibition.png phosphorylation FOXO 0.401
Identifier Residue Sequence Organism Cell Line
SIGNOR-259427 Homo sapiens
pmid sentence
Pim-mediated phosphorylation and inactivation of forkhead transcription factors, foxo1a and foxo3a, was involved in the transcriptional repression of the p27(kip1) gene.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ FOXOdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252910 Rattus norvegicus
pmid sentence
 FOXO1 coexpression dose-dependently repressed transcription from either the PPARgamma 1 or PPARgamma2 promoter reporter by 65%, whereas insulin (100 nm, 20-24 h) either partially or completely reversed this effect. 
Publications: 1 Organism: Rattus Norvegicus
+ FOXOup-regulates quantity by expression img/direct-activation.png transcriptional regulation FBXO32 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252926 Mus musculus C2C12 Cell
pmid sentence
The activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1 induction. IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-254991 Mus musculus
pmid sentence
These findings present new insights into the role of the GR and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene, a direct target of the GR in skeletal muscle.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252929 Mus musculus
pmid sentence
Constitutively active Foxo3 acts on the atrogin-1 promoter to cause atrogin-1 transcription and dramatic atrophy of myotubes and muscle fibers
Publications: 3 Organism: Mus Musculus
+ FOXOup-regulates activity img/indirect-activation.png transcriptional regulation TRIM63 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254990 Mus musculus
pmid sentence
Here, we show that in cultured myotubes undergoing atrophy, the activity of the PI3K/AKT pathway decreases, leading to activation of Foxo transcription factors and atrogin-1induction.
Publications: 1 Organism: Mus Musculus
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252914 Homo sapiens
pmid sentence
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252917 Homo sapiens
pmid sentence
Foxo1a strongly activated p15ink4b transcription and p19ink4d transcription, while foxo3a showed higher p19ink4d transcription activity than p15ink4b transcription activity
Publications: 1 Organism: Homo Sapiens
+ ERK1/2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.71
Identifier Residue Sequence Organism Cell Line
SIGNOR-270146 Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling
+ FOXOup-regulates quantity by expression img/direct-activation.png transcriptional regulation PCK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252924 Homo sapiens
pmid sentence
Phosphorylated foxo1 is inactive and retained in the cytosol. Mkp-3 mediated dephosphorylation activates foxo1 and subsequentially promotes its nuclear translocation and binding to the promoters of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase (pepck) and glucose-6-phosphatase (g6pase).
Publications: 1 Organism: Homo Sapiens
+ SIRT1up-regulates img/direct-activation.png deacetylation FOXO 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-252993 Homo sapiens
pmid sentence
Deacetylation of foxos involves binding of the nad-dependent deacetylase hsir2(sirt1). Accordingly, hsir2(sirt1)-mediated deacetylation precludes foxo inhibition through acetylation and thereby prolongs foxo-dependent transcription of stress-regulating genes.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation FASLG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252942 Homo sapiens
pmid sentence
Within the nucleus, fkhrl1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the fas ligand gene.
Publications: 1 Organism: Homo Sapiens
+ PRKAA1up-regulates img/direct-activation.png phosphorylation FOXO 0.509
Identifier Residue Sequence Organism Cell Line
SIGNOR-252981 Homo sapiens
pmid sentence
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt phosphorylation sites, resulting in foxo activation
Publications: 1 Organism: Homo Sapiens
+ AMPKup-regulates img/direct-activation.png phosphorylation FOXO 0.398
Identifier Residue Sequence Organism Cell Line
SIGNOR-252886 Homo sapiens
pmid sentence
The energy sensor amp-activated protein kinase (ampk) has been shown to directly phosphorylate foxo factors at six regulatory sites that are distinct from the akt phosphorylation sites, resulting in foxo activation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, NPM1_new
+ FOXOdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GK 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252919 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription foxo1 localizes to the nucleus, where it represses hnf-4-dependent activity of the gk promoter as a corepressor.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252927 Mus musculus C2C12 Cell
pmid sentence
Transcriptional reporter assays performed in both HepG2 and C2C12 cells demonstrate that the MuRF1 promoter is highly responsive to dexamethasone-activated glucocorticoid receptor (GR) and FoxO1 individually, while co-overexpression of GR and FoxO1 leads to a dramatic synergistic increase in reporter activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-252946 Homo sapiens
pmid sentence
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome.
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252945 Homo sapiens
pmid sentence
Foxo factors are required for the transcriptional regulation of the ubiquitin ligases atrogin-1, also called muscle atrophy f-box (mafbx) and muscle ring finger 1 (murf1), leading to the ubiquitylation of myosin and other muscle proteins, and their degradation via the proteasome.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ FOXOdown-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254306 Mus musculus
pmid sentence
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ HDAC1up-regulates activity img/direct-activation.png deacetylation FOXO 0.375
Identifier Residue Sequence Organism Cell Line
SIGNOR-256485 Mus musculus
pmid sentence
Through the use of various pharmacological inhibitors to block HDAC activity, we demonstrate that class I HDACs are key regulators of FoxO and the muscle-atrophy program during both nutrient deprivation and skeletal muscle disuse.
Publications: 1 Organism: Mus Musculus
Tissue: Muscle
+ Gbetadown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270020 Homo sapiens
pmid sentence
Phosphorylation of foxo3a by erk1/2 at residues ser 294, ser 344 and ser 425 increases foxo3amdm2 interaction and enhances foxo3a degradation via an mdm2-dependent ubiquitin-proteasome pathway
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252925 Homo sapiens
pmid sentence
Reporter gene studies in hepg2 hepatoma cells show that fkhr stimulates insulin-like growth factor-binding protein-1 promoter activity through an irs
Publications: 1 Organism: Homo Sapiens
+ FOXOdown-regulates img/indirect_inhibition.png PPARGC1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252916 Homo sapiens
pmid sentence
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252915 Homo sapiens
pmid sentence
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner.
Publications: 2 Organism: Homo Sapiens
+ SIRT1down-regulates quantity by destabilization img/direct_inhibition.png binding FOXO 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-252996 Mus musculus
pmid sentence
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ FOXOdown-regulates img/indirect_inhibition.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252938 Homo sapiens HEK-293 Cell
pmid sentence
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, IDH-TET in AML, FLT3-ITD in AML, FLT3-ITD signaling, NPM1_new, PI3K/AKT Signaling
+ TEAD1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOXO 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-253003 Homo sapiens
pmid sentence
Tead1 can regulate transcription of the foxo3a gene through the binding to the m-cat element, demonstrated with independent chip-pcr analysis, emsa and luciferase reporter system assay. The over-expression and inhibition analysis suggest that foxo3a was positively regulated by tead1.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252934 Homo sapiens NIH-3T3 Cell
pmid sentence
Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation CITED2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252933 Homo sapiens Breast Cancer Cell
pmid sentence
Foxo3a induces expression of cited2
Publications: 1 Organism: Homo Sapiens
+ PPARGC1Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOXO 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-252969 Mus musculus
pmid sentence
Capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy.overexpression of PGC-1_ inhibits muscle wasting induced by denervation, starvation, and even caFoxO3 expression
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ FOXOup-regulates img/indirect-activation.png Metabolism 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-253016
pmid sentence
Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body energy metabolism.
Publications: 1
+ SIRT1up-regulates activity img/direct-activation.png deacetylation FOXO 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-252994 Homo sapiens HEK-293 Cell
pmid sentence
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ SIRT1down-regulates img/indirect_inhibition.png FOXO 0.909
Identifier Residue Sequence Organism Cell Line
SIGNOR-252997 Mus musculus
pmid sentence
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ FOXOdown-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252940 Mus musculus Satellite Cell
pmid sentence
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ INSdown-regulates activity img/indirect_inhibition.png FOXO 0.491
Identifier Residue Sequence Organism Cell Line
SIGNOR-252952 Homo sapiens
pmid sentence
Insulin disrupts irs-dependent transactivation by fkhr, and phosphorylation of ser-256 by pkb is necessary and sufficient to mediate this effect.
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation G6P 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270252 Homo sapiens
pmid sentence
In the gk gene regulation, foxo1 represses hnf-4-potentiated transcription of the gene, whereas it synergizes with hnf-4 in activating the g6pase gene transcription.
Publications: 1 Organism: Homo Sapiens
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