Relation Results

Summary

Name RPS6K
Primary ID SIGNOR-PF26
Type protein family
Formed by RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5
Relations 86
Pathways FLT3-ITD signaling, Glutamine metabolism, Leptin Signaling, Myofiber: IGF1R, PI3K/AKT Signaling, Satellite: IGF1R

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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.20.20.20.20.20.6440.7520.7560.6010.720.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.550.4750.7160.3650.20.3650.20.4720.70.2RPS6KYBX1H3-3AL1CAMBADCREB1RANBP3MXD1ESR1CICTSC2CADETV1FLNAPDPK1MAPK1ERK1/2MAPK3RPS6MTORCCT2METTL1DEPTORCDC25ACDC25BFOSEEF2KNR4A3MITFEIF4BSTK11PPP1R3ACARHSP1SLC9A1RPTORGSK3BWWC1VASPmTORC1TSCIRS1TP53Histone H3Translational_regulationGbeta

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ RPS6Kup-regulates img/direct-activation.png phosphorylation YBX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252804 Ser102 NPRKYLRsVGDGETV Homo sapiens Breast Cancer Cell
pmid sentence
We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252806 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252815 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252808 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 3 Organism: Homo Sapiens
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation L1CAM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252766 Ser1152 RSKGGKYsVKDKEDT Rattus norvegicus PC-12 Cell
pmid sentence
Western blot analysis demonstrated that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk). Moreover, S6 kinase activity and p90(rsk) immunoreactivity co-immunoprecipitate with L1 from brain, and metabolic labeling studies have demonstrated that Ser1152 is phosphorylated in vivo in the developing rat brain. | These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152.
Publications: 1 Organism: Rattus Norvegicus
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation BAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252786 Ser118 GRELRRMsDEFVDSF Homo sapiens HEK-293 Cell
pmid sentence
Rsk1, and survival factor signaling stimulate phosphorylation of bad at ser-155, blocking the binding of bad to bcl-xl.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252767 Ser153 SWTRVFQsWWDRNLG Homo sapiens HEK-293 Cell
pmid sentence
We report here that the phosphorylation of BAD at Ser-155 within the BH3 domain is a second phosphorylation-dependent mechanism that inhibits the death-promoting activity of BAD. Protein kinase A, RSK1, and survival factor signaling stimulate phosphorylation of BAD at Ser-155, blocking the binding of BAD to Bcl-XL. RSK1 phosphorylates BAD at both Ser-112 and Ser-155 and rescues BAD-mediated cell death in a manner dependent upon phosphorylation at both sites.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252784 Ser75 EIRSRHSsYPAGTED Homo sapiens Melanoma Cell
pmid sentence
To understand the mechanisms underlying B-RAF effects on cell survival we initially analysed the Bcl-2 family protein, Bad, that is phosphorylated by RSK1 at the inhibitory serine-75 residue in a MEK-dependent manner in melanoma cells
Publications: 3 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation CREB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252782 Ser119 EILSRRPsYRKILND Homo sapiens Neuron
pmid sentence
The rsks phosphorylate the trascription factor creb at serine 133 to promote cell survival.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ RPS6K img/unknown.png phosphorylation RANBP3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252770 Ser126 VKRERTSsLTQFPPS Homo sapiens
pmid sentence
Rsk phosphorylates serine 58 of ranbp3 in vitro and in vivo
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation MXD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252811 Ser145 IERIRMDsIGSTVSS Homo sapiens
pmid sentence
In this study, we showed that mad1 is a substrate of p90 ribosomal kinase (rsk) and p70 s6 kinase (s6k). Both rsk and s6k phosphorylate serine 145 of mad1 upon serum or insulin stimulation. Ser-145 phosphorylation of mad1 accelerates the ubiquitination and degradation of mad1 through the 26s proteasome pathway
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation ESR1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252807 Ser167 GGRERLAsTNDKGSM Homo sapiens Breast Cancer Cell
pmid sentence
Serine 167 is the major phosphorylation site on the human estrogen receptor. Phosphorylation is mediated by casein kinase ii.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation CIC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252778 Ser173 PGKRRTQsLSALPKE Homo sapiens Melanoma Cell
pmid sentence
Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3)
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation TSC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252801 Ser1798 GQRKRLIsSVEDFTE Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation CAD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267197 Ser1859 PPRIHRAsDPGLPAE Homo sapiens HEK-293 Cell
pmid sentence
Activation of mTORC1 led to the acute stimulation of metabolic flux through the de novo pyrimidine synthesis pathway. mTORC1 signaling posttranslationally regulated this metabolic pathway via its downstream target ribosomal protein S6 kinase 1 (S6K1), which directly phosphorylates S1859 on CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase), the enzyme that catalyzes the first three steps of de novo pyrimidine synthesis.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamine metabolism
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation ETV1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252768 Ser191 HRFRRQLsEPCNSFP Homo sapiens
pmid sentence
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252769 Ser216 PMYQRQMsEPNIPFP Homo sapiens
pmid sentence
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation.
Publications: 2 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation FLNA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252790 Ser2152 TRRRRAPsVANVGSH Homo sapiens Melanoma Cell
pmid sentence
We show that the n-terminal kinase domain of rsk phosphorylates flna on ser(2152) in response to mitogens
Publications: 1 Organism: Homo Sapiens
+ PDPK1up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-252763 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS-7 Cell
pmid sentence
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ MAPK1up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.752
Identifier Residue Sequence Organism Cell Line
SIGNOR-252750 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252754 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252748 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252747 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252751 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252753 Thr573 AENGLLMtPCYTANF Homo sapiens
pmid sentence
Thus, MAPK1/ERK1 and MAPK2/ERK2 activate three closely related protein kinases known as MAPK_activated protein kinases_1a, _1b and _1c (MAPKAP_K1a/b/c; also known as RSK1/2/3)
Identifier Residue Sequence Organism Cell Line
SIGNOR-252752 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252749 Homo sapiens
pmid sentence
Efficient rsk activation by erk requires its interaction through a docking site located near the c terminus of rsk
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ ERK1/2up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-252741 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252742 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252746 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252744 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252745 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252743 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:FLT3-ITD signaling, Leptin Signaling, PI3K/AKT Signaling
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation RPS6K 0.601
Identifier Residue Sequence Organism Cell Line
SIGNOR-252785 Ser221 DHEKKAYsFCGTVEY Homo sapiens HEK-293 Cell
pmid sentence
Herein, we demonstrate that the n-terminal kinase domain (ntk) of rsk1 is necessary for interactions with pkarialpha. Substitution of the activation loop phosphorylation site (ser-221) in the ntk with the negatively charged asp residue abrogated the association between rsk1 and pkarialpha.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Glutamine metabolism, Leptin Signaling, PI3K/AKT Signaling
+ MAPK3up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.72
Identifier Residue Sequence Organism Cell Line
SIGNOR-252758 Ser221 DHEKKAYsFCGTVEY Chlorocebus aethiops
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252759 Ser363 TSRTPKDsPGIPPSA Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252756 Ser380 HQLFRGFsFVATGLM Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252761 Ser732 RRVRKLPsTTL Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252755 Thr359 DTEFTSRtPKDSPGI Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252757 Thr573 AENGLLMtPCYTANF Chlorocebus aethiops COS-1 Cell
pmid sentence
Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252760 Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252762 Mus musculus
pmid sentence
The pp90rsk phosphothreonine content paralleled the ERK1 activity more closely than the phosphoserine level. These results provide compelling evidence that in fibroblasts and PC12 cells ERK1 plays a direct role in the phosphorylation of pp90rsk and that pp90rsk represents a physiologically relevant substrate of extracellular-regulated kinases
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens, Mus Musculus
+ RPS6Kup-regulates img/direct-activation.png phosphorylation RPS6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252813 Ser235 IAKRRRLsSLRASTS Homo sapiens
pmid sentence
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252812 Ser236 AKRRRLSsLRASTSK Homo sapiens
pmid sentence
We demonstrate that while ribosomal s6 kinase 1 (s6k1) phosphorylates rps6 at all sites, rsk exclusively phosphorylates rps6 at ser(235/236) in vitro and in vivo using an mtor-independent mechanism.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252765 Ser240 RLSSLRAsTSKSESS Homo sapiens
pmid sentence
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-252764 Ser244 LRASTSKsESSQK Homo sapiens
pmid sentence
In response to mitogenic stimuli, rps6 undergoes ordered c-terminal phosphorylation by p70 s6 kinases and p90 ribosomal s6 kinases on four conserved ser residues (ser-235, ser-236, ser-240, and ser-244) whose modification potentiates rps6 cap binding activity
Publications: 4 Organism: Homo Sapiens
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation MTOR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-137251 Ser2448 RSRTRTDsYSAGQSV Homo sapiens
pmid sentence
Importantly, phosphorylation of mTOR by S6K1 occurs at threonine 2446/serine 2448. This region has been shown previously to be part of a regulatory repressor domain. These sites are also constitutively phosphorylated in the breast cancer cell line MCF7 carrying an amplification of the S6K1 geneit has been proposed that other inputs, in addition to phosphorylation of Thr-2446/Ser-2448 by S6K1, are part of the mechanism involved in inhibiting this repressor domain
Identifier Residue Sequence Organism Cell Line
SIGNOR-137255 Thr2446 NKRSRTRtDSYSAGQ Homo sapiens
pmid sentence
Importantly, phosphorylation of mTOR by S6K1 occurs at threonine 2446/serine 2448. This region has been shown previously to be part of a regulatory repressor domain. These sites are also constitutively phosphorylated in the breast cancer cell line MCF7 carrying an amplification of the S6K1 geneit has been proposed that other inputs, in addition to phosphorylation of Thr-2446/Ser-2448 by S6K1, are part of the mechanism involved in inhibiting this repressor domain
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Leptin Signaling
+ RPS6Kup-regulates img/direct-activation.png phosphorylation CCT2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252780 Ser260 GSRVRVDsTAKVAEI Homo sapiens
pmid sentence
Furthermore, both the s260a and s260d mutants showed a decreased folding capacity as compared to cells expressing the wild-type cct_ subunit ( fig.?_5e), suggesting that a cyclic phosphorylation of the s260 site by s6k1 is likely to be important for chaperonin function and that mutation of this site interferes with this process.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation METTL1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252800 Ser27 YYRQRAHsNPMADHT Homo sapiens HEK-293 Cell, HeLa Cell
pmid sentence
Pkb and ribosomal s6 kinase (rsk) both phosphorylated mettl1 at ser27 in vitro.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation DEPTOR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252797 Ser286 SSMSSCGsSGYFSSS Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Identifier Residue Sequence Organism Cell Line
SIGNOR-252798 Ser287 SMSSCGSsGYFSSSP Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Identifier Residue Sequence Organism Cell Line
SIGNOR-252799 Ser291 CGSSGYFsSSPTLSS Homo sapiens
pmid sentence
We found that deptor was rapidly phosphorylated on three serines in a conserved degron, facilitating binding and ubiquitylation by the f box protein _trcp, with consequent proteasomal degradation of deptor. Phosphorylation of the _trcp degron in deptor is executed by ck1
Publications: 3 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation CDC25A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252793 Ser293 GSTKRRKsMSGASPK Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252776 Ser295 TKRRKSMsGASPKES Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Publications: 2 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation CDC25B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252781 Ser353 VQNKRRRsVTPPEEQ Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252779 Thr355 NKRRRSVtPPEEQQE Homo sapiens
pmid sentence
Rsk promotes g2/m transition through activating phosphorylation of cdc25a and cdc25b rsk is likely to be more active in mitotic cells than in interphase cells, as evidenced by the phosphorylation status of t359/s363 in rsk. Together, these findings indicate that rsk promotes g2/m transition in mammalian cells through activating phosphorylation of cdc25a and cdc25b.
Publications: 2 Organism: Homo Sapiens
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation FOS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252789 Ser362 AAAHRKGsSSNEPSS Homo sapiens
pmid sentence
We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kda ribosomal s6 kinase (rsk) and mitogen-activated protein kinase (map kinase), contribute to the serum-induced phosphorylation of c-fos. The major phosphopeptides derived from biosynthetically labeled c-fos correspond to phosphopeptides generated after phosphorylation of c-fos in vitro with both rsk and map kinase. The phosphorylation sites identified for rsk (ser-362) and map kinase (ser-374) are in the transrepression domain. Cooperative phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the peptide phosphorylated on both sites, as opposed to singly phosphorylated peptides. This study suggests a role for nuclear rsk and map kinase in modulating newly synthesized c-fos phosphorylation and downstream signaling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-262998 Ser374 PSSDSLSsPTLLAL
pmid sentence
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos
Publications: 2 Organism: Homo Sapiens,
Pathways:Leptin Signaling
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252775 Ser366 SPQVRTLsGSRPPLL Homo sapiens
pmid sentence
We show that two such kinases, p70 s6 kinase (regulated via mtor) and p90(rsk1) (activated by erk), phosphorylate eef2k at a conserved serine and inhibit its activity
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation NR4A3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252771 Ser376 GRRGRLPsKPKSPLQ Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation of Nur77 on Ser354 has been suggested to reduce ability of Nur77 to bind DNA; however, the kinase responsible for this phosphorylation in cells has not been clearly established. In the present study, we show that Nur77 is phosphorylated on this site by RSK (ribosomal S6 kinase)
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation MITF 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252791 Ser409 HGLSLIPsTGLCSPD Homo sapiens
pmid sentence
The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73, whereas serine 409 serves as a substrate for p90 rsk-1. An unphosphorylatable double mutant at these two residues is at once profoundly stable and transcriptionally inert.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252795 Ser409 HGLSLIPsTGLCSPD Homo sapiens
pmid sentence
The current study reveals that c-kit signaling triggers two phosphorylation events on mi, which up-regulate transactivation potential yet simultaneously target mi for ubiquitin-dependent proteolysis. The specific activation/degradation signals derive from mapk/erk targeting of serine 73, whereas serine 409 serves as a substrate for p90 rsk-1. An unphosphorylatable double mutant at these two residues is at once profoundly stable and transcriptionally inert.
Publications: 2 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation EIF4B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252783 Ser422 RERSRTGsESSQTGT Homo sapiens
pmid sentence
S6k1/s6k2 specifically phosphorylate ser422 in vitro. Substitution of ser422 with ala results in a loss of activity in an in vivo translation assay, indicating that phosphorylation of this site plays an important role in eif4b function.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation STK11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252805 Ser428 SSKIRRLsACKQQ Homo sapiens Leukemia Cell
pmid sentence
Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cellsBRAFV600E activates downstream molecules, including ERK and p90 ribosomal S6 kinase (RSK), and leads to the phosphorylation of LKB-1 at Ser428 by these kinases. This cascade results in the dissociation of LKB1 from AMPK.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation PPP1R3A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252777 Ser46 PQPSRRGsDSSEDIY in vitro
pmid sentence
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3',5' cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-1 (MAPKAP-K1, also called p90 RSK). The phosphorylation of Ser48 increases the rate at which the glycogen-associated PP1.G(M) complex dephosphorylates (activates) glycogen synthase, but the phosphorylation of Ser67 has the opposite effect, suppressing the activity of PP1 toward glycogen-bound substrates.
Publications: 1 Organism: In Vitro
+ RPS6K img/unknown.png phosphorylation CARHSP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252814 Ser52 TRRTRTFsATVRASQ Homo sapiens
pmid sentence
These and other results demonstrate that crhsp24 is phosphorylated at ser52 by pkbalpha in response to igf-1, at ser52 by pkbalpha and rsk in response to egf
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ RPS6Kup-regulates img/direct-activation.png phosphorylation SLC9A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252792 Ser703 MSRARIGsDPLAYEP Homo sapiens
pmid sentence
The results indicate that p90rsk phosphorylates serine 703 of nhe-1, and this phosphorylation is required for growth factor stimulation of na+/h+ exchange.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation RPTOR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252772 Ser719 PCTPRLRsVSSYGNI Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-252774 Ser721 TPRLRSVsSYGNIRA Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Identifier Residue Sequence Organism Cell Line
SIGNOR-252773 Ser722 PRLRSVSsYGNIRAV Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 3 Organism: Homo Sapiens
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation GSK3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252788 Ser9 SGRPRTTsFAESCKP Homo sapiens
pmid sentence
S6k then phosphorylates the same serine residue on gsk3 that is targeted by pkb/akt (fig. 1), thereby inhibiting its activity.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ RPS6Kup-regulates img/direct-activation.png phosphorylation WWC1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252809 Ser947 CRLNRSDsDSSTLSK Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. erk_rsk phosphorylation of kibra is required for proper cell proliferation and rsk-mediated phosphorylation also positively modulates kibra's migratory activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-252810 Thr929 STIIRSKtFSPGPQS Homo sapiens
pmid sentence
Moreover, we found that rsk1/2 specifically phosphorylates kibra at two highly conserved sites (thr(929) and ser(947)) in vitro and in cells. Rsk-mediated phosphorylation is required for kibra binding to rsk1, but not rsk2.
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ RPS6Kdown-regulates img/direct_inhibition.png phosphorylation VASP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252802 Thr278 LARRRKAtQVGEKTP Homo sapiens Lung Cancer Cell
pmid sentence
Rsk1 phosphorylated vasp on t278, a site regulating its binding to actin.
Publications: 1 Organism: Homo Sapiens
+ MTORup-regulates activity img/direct-activation.png phosphorylation RPS6K 0.55
Identifier Residue Sequence Organism Cell Line
SIGNOR-255841 Thr390 DSKFTRQtPVDSPDD Homo sapiens
pmid sentence
Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain,[…] Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Leptin Signaling
+ mTORC1up-regulates activity img/direct-activation.png phosphorylation RPS6K 0.475
Identifier Residue Sequence Organism Cell Line
SIGNOR-255842 Thr390 DSKFTRQtPVDSPDD Homo sapiens
pmid sentence
Thr229 phosphorylation requires prior phosphorylation of the Ser/Thr-Pro sites in the autoinhibitory domain and Thr389 in the linker domain [..]. Moreover, in vitro mTOR directly phosphorylates Ser371, and this event modulates Thr389phosphorylation by mTOR, compatible with earlier in vivo findings.
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation TSC 0.716
Identifier Residue Sequence Organism Cell Line
SIGNOR-256311 Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
+ GSK3Bup-regulates activity img/direct-activation.png phosphorylation RPS6K 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-263513 Homo sapiens
pmid sentence
GSK3β regulates S6K1 activity positively through modulating phosphorylation of S6K1 at p.Ser371.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, PI3K/AKT Signaling
+ RPS6Kdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252787 Homo sapiens
pmid sentence
Negative feedback involves s6k, which inactivates irs by phosphorylation at multiple sites, thus inducing its degradation and altered cell localization.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Leptin Signaling
+ TP53up-regulates img/indirect-activation.png RPS6K 0.365
Identifier Residue Sequence Organism Cell Line
SIGNOR-252816 Homo sapiens
pmid sentence
Rather, p53 expression stimulates the serine/threonine kinase ribosomal s6 kinase 1 (rsk1), which in turn phosphorylates the p65 subunit of nf-kb.
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ RPS6Kdown-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265345 Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates activity img/direct-activation.png phosphorylation mTORC1 0.472
Identifier Residue Sequence Organism Cell Line
SIGNOR-252796 Homo sapiens HEK-293 Cell
pmid sentence
The mitogen-activated protein kinase (mapk)-activated kinase, p90 ribosomal s6 kinase (rsk) 1, was found to interact with and phosphorylate tuberin at a regulatory site, ser-1798, located at the evolutionarily conserved c terminus of tuberin. Rsk1 phosphorylation of ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mtor signaling to s6k1
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ RPS6Kup-regulates img/indirect-activation.png Translational_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268527 Homo sapiens
pmid sentence
Mutation of rpS6 at Ser(235/236) reveals that phosphorylation of these sites promotes its recruitment to the 7-methylguanosine cap complex, suggesting that Ras/ERK signaling regulates assembly of the translation preinitiation complex. These data demonstrate that RSK provides an mTOR-independent pathway linking the Ras/ERK signaling cascade to the translational machinery.
Publications: 1 Organism: Homo Sapiens
+ RPS6Kup-regulates img/direct-activation.png phosphorylation mTORC1 0.472
Identifier Residue Sequence Organism Cell Line
SIGNOR-252794 Homo sapiens
pmid sentence
Ser719, ser721, and ser722 are the predominant rsk-dependent phosphorylation sites in raptor raptor phosphorylation regulates mtorc1 activity
Publications: 1 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ Gbetaup-regulates activity img/direct-activation.png phosphorylation RPS6K 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270006 Homo sapiens HEK-293 Cell
pmid sentence
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.Erk-activates the rsk family of serine/threonine kinases,rsk1, rsk2, and rsk3.
Publications: 1 Organism: Homo Sapiens
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