Relation Results

Summary

Name TEAD
Primary ID SIGNOR-PF22
Type protein family
Formed by TEAD1, TEAD2, TEAD3, TEAD4
Relations 4
Pathways Hippo in cancer, Hippo Signaling, Integrin Signaling, YAP/TAZ regulation

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Type: Score: Layout: SPV 
0.8950.940.3590.94WWTR1TEADYAP1AP1YAP/TAZ

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Relations
Regulator
Mechanism
target
score ℹ
+ WWTR1up-regulates activity img/direct-activation.png binding TEAD 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-230722 Homo sapiens
pmid sentence
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling, Integrin Signaling
+ YAP1up-regulates activity img/direct-activation.png binding TEAD 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-230719 Homo sapiens
pmid sentence
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo in cancer, Hippo Signaling, Integrin Signaling
+ TEADup-regulates activity img/direct-activation.png binding AP1 0.359
Identifier Residue Sequence Organism Cell Line
SIGNOR-277658 Homo sapiens
pmid sentence
YAP/TAZ/TEAD and AP-1 form a complex that synergistically activates target genes directly involved in the control of S-phase entry and mitosis.
Publications: 1 Organism: Homo Sapiens
+ YAP/TAZup-regulates activity img/direct-activation.png binding TEAD 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-277635 Homo sapiens
pmid sentence
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death
Publications: 1 Organism: Homo Sapiens
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