Relation Results

Summary

Name TLRs
Primary ID SIGNOR-PF20
Type protein family
Formed by TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9
Relations 10
Pathways COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors

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Type: Score: Layout: SPV 
0.20.20.70.70.20.20.70.20.70.2TLRsNLRP3TICAM1PAMPsImmune_responseTIRAPMYD88DAMPSInterferon_ProductionTICAM2

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Relations
Regulator
Mechanism
target
score ℹ
+ TLRsup-regulates quantity by expression img/indirect-activation.png NLRP3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256428
pmid sentence
The activation of NLRP3 inflammasomes in macrophages requires two stimuli. The first signal, called priming, is provided by an inflammatory stimulus such as TLRs and TNF-α receptor (TNFR) that leads to NF-κB-mediated NLRP3 expression and post-translational modifications of NLRP3
Publications: 1
+ TLRsup-regulates activity img/direct-activation.png binding TICAM1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252095 Mus musculus
pmid sentence
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ PAMPsup-regulates img/indirect-activation.png TLRs 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-216295 Homo sapiens
pmid sentence
the discovery of Toll-like receptors (TLRs) in the mid-1990s showed that pathogen recognition by the innate immune system is instead actually specific, relying on germline-encoded pattern-recognition receptors (PRRs) that have evolved to detect components of foreign pathogens referred to as pathogen-associated molecular patterns (PAMPs)
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ TLRsup-regulates img/indirect-activation.png Immune_response 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-216304 Homo sapiens
pmid sentence
The negative regulation of TLR-induced responses is important for sup- pressing inflammation and deleterious immune responses.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding TIRAP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-216298 Homo sapiens
pmid sentence
These differences are explained by the discovery of TIR domain’containing adaptor molecules, including MyD88, TIRAP (Mal), TRIF and TRAM, which are recruited by distinct TLRs and activate distinct signaling pathways
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding MYD88 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260151 Mus musculus
pmid sentence
To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ DAMPSup-regulates activity img/direct-activation.png binding TLRs 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252096 Homo sapiens
pmid sentence
The innate immune system is present in almost all multicellular organisms and its activation occurs in response to pathogens or tissue injury via pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs)
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, Inflammosome Activation, Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding TLRs 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-216301 Homo sapiens
pmid sentence
Upon activation, tlrs hetero- or homodimerize inducing the recruitment of adaptor proteins via the cytoplasmic tir domain
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors
+ TLRsup-regulates img/indirect-activation.png Interferon_Production 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-216310 Homo sapiens
pmid sentence
TLR signaling pathways can be largely classified as either MyD88-dependent pathways, which drive the induction of inflammatory cytokines, or TRIF-dependent pathways, which are responsible for the induction of type I interferon as well as inflammatory cytokines3.
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ TLRsup-regulates activity img/direct-activation.png binding TICAM2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-216307 Homo sapiens
pmid sentence
These differences are explained by the discovery of TIR domain’containing adaptor molecules, including MyD88, TIRAP (Mal), TRIF and TRAM, which are recruited by distinct TLRs and activate distinct signaling pathways
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
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