Relation Results

Summary

Name LPAR
Primary ID SIGNOR-PF2
Type protein family
Formed by LPAR1, LPAR2, LPAR3
Relations 8

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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.2LPARPCBP2GNAI3GNAI1GNAQGNA13GNA14GNAO1GNA12

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ LPARup-regulates quantity by stabilization img/direct-activation.png phosphorylation PCBP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-262669 Ser189 YRPKPSSsPVIFAGG Mus musculus KB Cell
pmid sentence
All together, these data indicate that ERK-dependent phosphorylation of hnRNP-E2 at serines 173, 189, and 272, and threonine 213 is responsible for increased hnRNP-E2 protein stability in BCR/ABL-transformed cells.
Publications: 1 Organism: Mus Musculus
+ LPARup-regulates activity img/direct-activation.png binding GNAI3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269969 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ‚â• -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ‚â• -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ‚â• -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPARup-regulates img/direct-activation.png binding GNAI1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269964 Homo sapiens
pmid sentence
We conclude that lpa(1) receptors couple to a g(i)-phosphoinositide 3-kinase-tiam1 pathway to activate rac.
Publications: 1 Organism: Homo Sapiens
+ LPARup-regulates img/direct-activation.png binding GNAQ 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269966 Homo sapiens
pmid sentence
The receptor, now called lpa1, is a gpcr that couples to heterotrimeric g proteins (gi, gq, g12/13alpha subunits)
Publications: 1 Organism: Homo Sapiens
+ LPARup-regulates img/direct-activation.png binding GNA13 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269965 Mus musculus NIH-3T3 Cell
pmid sentence
Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13.
Publications: 1 Organism: Mus Musculus
+ LPARup-regulates activity img/direct-activation.png binding GNA14 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269963 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ‚â• -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ‚â• -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ‚â• -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPARup-regulates activity img/direct-activation.png binding GNAO1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269967 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ‚â• -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ‚â• -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ‚â• -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPARup-regulates img/direct-activation.png binding GNA12 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269968 Mus musculus NIH-3T3 Cell
pmid sentence
Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13.
Publications: 1 Organism: Mus Musculus
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